Flopropione
- Product Name
- Flopropione
- CAS No.
- 2295-58-1
- Chemical Name
- Flopropione
- Synonyms
- Labroda;Chlonarin;Pasmus;SKL632;Argobyl;Ecapron;Flopion;Cospanon;Labrodax;Profenon
- CBNumber
- CB6780852
- Molecular Formula
- C9H10O4
- Formula Weight
- 182.17
- MOL File
- 2295-58-1.mol
Flopropione Property
- Melting point:
- 177°C
- Boiling point:
- 275.56°C (rough estimate)
- Density
- 1.2481 (rough estimate)
- refractive index
- 1.4500 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
- form
- powder to crystal
- pka
- 7.49±0.45(Predicted)
- color
- White to Orange to Green
- Merck
- 14,4106
- LogP
- 2.600 (est)
- CAS DataBase Reference
- 2295-58-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Flopropione(2295-58-1)
- EPA Substance Registry System
- 1-Propanone, 1-(2,4,6-trihydroxyphenyl)- (2295-58-1)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- RTECS
- UH4429100
- HS Code
- 2914.50.3000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- T0887
- Product name
- 2',4',6'-Trihydroxypropiophenone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- CS-8184
- Product name
- Flopropione
- Purity
- 98.93%
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- J55538
- Product name
- Flopropione
- Packaging
- 25g
- Price
- $172
- Updated
- 2021/12/16
- Product number
- CHM0007822
- Product name
- 2',4',6'-TRIHYDROXYPROPIOPHENONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.83
- Updated
- 2021/12/16
- Product number
- MT-31560
- Product name
- 2,4,6-Trihydroxypropiophenone
- Purity
- 98%
- Packaging
- 250g
- Price
- $550
- Updated
- 2021/12/16
Flopropione Chemical Properties,Usage,Production
Uses
antispasmodic
Preparation
Preparation by reaction of propionitrile with phlo-roglucinol (Hoesch reaction);
Preparation by reaction of propionic anhydride with phloroglucinol
in the presence of concentrated sulfuric acid (one drop) at 130° for 5 min ? (65%)
in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid ? type) at 160° for 2–3 h (42%). N.B.: Zeokarb 225 was found to be as effective
in the presence of boron trifluoride etherate at 10° (62–65%)
Preparation by reaction of propionyl chloride with phloroglucinol
in the presence of aluminium chloride in nitrobenzene/carbon disulfide ? solution (76%), in nitrobenzene at 60° (55%) or without solvent at 50° (70%)
in the presence of boron trifluoride etherate at 10° (compound ? 3) (62–65%).
Definition
ChEBI: Flopropione is an organic molecular entity.
Synthesis
108-73-6
79-03-8
2295-58-1
General procedure: Anhydrous AlCl3 (4 eq.) was slowly added to a stirred suspension of resorcinol (1 eq.) in CS2. Subsequently, nitrobenzene was added dropwise over 30 minutes. The reaction mixture was refluxed at 55 °C for 30 min. Next, propionyl chloride (1 eq.) dissolved in nitrobenzene was slowly added over 30 min and the reaction mixture continued to be heated for 30 min. Upon completion of the reaction, the mixture was allowed to cool to room temperature with stirring, followed by slow pouring into an ice water bath. 3M HCl was added to quench the reaction. The organic solvent was removed by distillation under reduced pressure and the resulting oily residue was extracted with Et2O. After extraction, Et2O was removed by evaporation and the crude product was purified by fast chromatography (eluent: petroleum ether (boiling point 50-70 °C)/ethyl acetate, ratio tapered from 5:1 to 3:1).
in vivo
The effect of Flopropione as an antispasmodic agent on the rate of passing a calculus from the urinary tract has been compared retrospectively with patients in whom passage was spontaneous. Flopropine has been shown, with statistical significance, to be superior to the control in cumulative passage rate after initiation of administration. Flopropine has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreatobiliary and urinary systems[3].
IC 50
5-HT1A Receptor; COMT
References
[1] Agricultural and Biological Chemistry, 1985, vol. 49, # 3, p. 719 - 724
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 621 - 628
[3] Australian Journal of Chemistry, 2005, vol. 58, # 7, p. 551 - 555
[4] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 255 - 262
[5] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 13, p. 4402 - 4409
Flopropione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Flopropione manufacturers
- Product
- Flopropione 2295-58-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09