DL-NORPHENYLEPHRINE HYDROCHLORIDE Property

Melting point:

162-164 °C(lit.)

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Merck 

14,6699

Safety

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

RTECS 

DN7400000

HS Code 

2922504500

Toxicity

LD50 oral in rat: 390mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

DL-NORPHENYLEPHRINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Originator

Zordel,Grelan,Japan,1970

Uses

rac Norphenylephrine Hydrochloride is an Impurity A of phenylephrine. A phenylephrine derivative as leukotriene D4 antagonists.

Definition

ChEBI: Norfenefrine hydrochloride is a member of phenols.

Manufacturing Process

100 parts of the hydrochloride of meta-hydroxy-ω-aminoacetophenone of melting point 220°C to 222°C (obtainable by brominating metaacetoxyacetophenone, causing the bromoketone to react with sodium iodide, adding hexamethylenetetramine to the iodide in an indifferent solvent and scission of the addition product in acid solution) are shaken in aqueous solution with hydrogen in presence of 2 parts of palladium catalyst until 2 atomic proportions of hydrogen have been absorbed. The catalyst is now filtered and the filtrate evaporated in a vacuum; and the crystalline and completely dry residue is dissolved in absolute alcohol and a precipitate is produced by adding dry ether. The hydrochloride of metahydroxyphenylethanolamine thus obtained forms white crystals of melting point 159°C to 160°C.

Therapeutic Function

Adrenergic