ChemicalBook > CAS DataBase List > 3-CHLORO-6-METHOXYPYRIDAZINE
3-CHLORO-6-METHOXYPYRIDAZINE
- Product Name
- 3-CHLORO-6-METHOXYPYRIDAZINE
- CAS No.
- 1722-10-7
- Chemical Name
- 3-CHLORO-6-METHOXYPYRIDAZINE
- Synonyms
- NSC 69819;NSC 522667;TIMTEC-BB SBB004124;SPECS AC-907/25014054;3-Chloro-6-methoxypyrazine;6-Chloro-3-methoxypyridazine;3-Methoxy-6-chloropyridazine;3-CHLORO-6-METHOXYPYRIDAZINE;3-Chloro-6-methoxy-1,2-diazine;pyridazine, 3-chloro-6-methoxy-
- CBNumber
- CB9437764
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 1722-10-7.mol
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3-CHLORO-6-METHOXYPYRIDAZINE Property
- Melting point:
- 84-85 °C(lit.)
- Boiling point:
- 285℃
- Density
- 1.292
- Flash point:
- 126℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 0.74±0.10(Predicted)
- color
- White to Almost white
- BRN
- 118854
- InChI
- InChI=1S/C5H5ClN2O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3
- InChIKey
- XBJLKXOOHLLTPG-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NN=C(OC)C=C1
- CAS DataBase Reference
- 1722-10-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 108596
- Product name
- 3-Chloro-6-methoxypyridazine
- Purity
- 95%
- Packaging
- 5g
- Price
- $111
- Updated
- 2023/01/07
TCI Chemical
- Product number
- C2376
- Product name
- 3-Chloro-6-methoxypyridazine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $75
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C2376
- Product name
- 3-Chloro-6-methoxypyridazine
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $298
- Updated
- 2025/07/31
TRC
- Product number
- C368103
- Product name
- 3-Chloro-6-methoxypyridazine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
Chem-Impex
- Product number
- 44627
- Product name
- 3-Chloro-6-methoxypyridazine,≥97%(GC)
- Purity
- ≥97%(GC)
- Packaging
- 5G
- Price
- $56.28
- Updated
- 2021/12/16
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3-CHLORO-6-METHOXYPYRIDAZINE Chemical Properties,Usage,Production
Uses
3-Chloro-6-methoxypyridazine was used in the preparation of number of α-aryl-α-(pyridazin-3-yl)-acetonitriles.
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 1466, 1995 DOI: 10.1021/jo00110a059
General Description
3-Chloro-6-methoxypyridazine undergoes regioselective metallation using various lithium alkylamides, temperatures and solvents (THF and ether). It was lithiated using lithium 2,2,6,6-tetramethylpiperidide during the synthesis of minaprine.
Synthesis
141-30-0
124-41-4
1722-10-7
A methanolic solution of 0.5 M sodium methanolate (NaOMe/MeOH, 7.4 mL, 3.69 mmol) was slowly added dropwise to a solution of anhydrous tetrahydrofuran (12 mL) containing 3,6-dichloropyridazine (500 mg, 3.36 mmol), and the reaction mixture was stirred for 1 h at room temperature. Subsequently, the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate and the organic phases were combined. The organic phase was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to afford 6-methoxy-3-chloropyridazine (436 mg, 90% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 4.12 (s, 3H), 6.98 (d, J = 9.2 Hz, 1H), 7.38 (d, J = 9.2 Hz, 1H); 13C NMR (100 MHz, CDCl3) δ 55.5 (d, J = 9.2 Hz, 1H). CDCl3) δ 55.2, 119.9, 130.6, 150.9, 164.2.
References
[1] Journal of Heterocyclic Chemistry, 2005, vol. 42, # 4, p. 509 - 513
[2] Patent: US2010/261727, 2010, A1. Location in patent: Page/Page column 31
[3] ACS Chemical Neuroscience, 2017, vol. 8, # 11, p. 2374 - 2380
[4] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 5, p. 1165 - 1173
[5] Journal of the American Chemical Society, 1959, vol. 81, p. 6511,6512
3-CHLORO-6-METHOXYPYRIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLORO-6-METHOXYPYRIDAZINE manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- 3-Chloro-6-methoxypyridazine 1722-10-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
Shanghai Rlavie Technology Co ltd
- Product
- 3-Chloro-6-methoxypyridazine 1722-10-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 300kgs/month
- Release date
- 2021-11-14
Dideu Industries Group Limited
- Product
- 3-CHLORO-6-METHOXYPYRIDAZINE 1722-10-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02
1722-10-7, 3-CHLORO-6-METHOXYPYRIDAZINERelated Search:
3-Chloro-6-methylpyridazine
6-chloro-N-(propan-2-yl)pyridazin-3-amine
3-chloro-6-(chloroMethyl)pyridazine hydrochloride
3-Chloro-6-trifluoromethyl-pyridazine
3-Chloro-6-chloromethylpyridazine
3-chloro-6-isopropylpyridazine
3-CHLORO-6-PROPYLOXYPYRIDAZINE
3-Chloro-6-hydrazinopyridazine
3-Chloro-6-(1H-pyrazol-1-yl)pyridazine
6-Chloro-N-ethylpyridazin-3-amine
3-Chloro-6-iodopyridazine
6-CHLOROPYRIDAZINE-3-THIOL
3-CHLORO-6-PHENYLPYRIDAZINE
3-(TERT-BUTOXY)-6-CHLOROPYRIDAZINE
3-CHLORO-6-PHENOXYPYRIDAZINE
3-CHLORO-6-ISOPROPOXYPYRIDAZINE
3-CHLORO-6-ETHOXYPYRIDAZINE
2-Chloro-10-methyl-3,4-diazaphenoxazine