8-HYDROXYJULOLIDINE-9-ALDEHYDE

Product Name: 8-HYDROXYJULOLIDINE-9-ALDEHYDE
CAS No.: 63149-33-7
Chemical Name: 8-HYDROXYJULOLIDINE-9-ALDEHYDE
Synonyms: AKOS NCG-0055;9-Formyl-8-julolidinol;9-FORMYL-8-HYDROXYJULOLIDINE;8-hydroxyjulolodine-9-aldehyde;8-HYDROXYJULOLIDINE-9-ALDEHYDE;9-Formyl-8-hydroxyjulolidine, 97%,;8-HYDROXYJULOLIDINE-9-CARBOXALDEHYDE;8-Hydroxyjulolidine-9-carboxaldehyde>9-FORMYL-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ]QUINOLIZIN-8-OL;2,3,6,7-TETRAHYDRO-8-HYDROXY-1H,5H-BENZO[IJ]QUINOLIZINE-9-CARBALDEHYDE
CBNumber: CB9440223
Molecular Formula: C13H15NO2
Formula Weight: 217.26
MOL File: 63149-33-7.mol

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8-HYDROXYJULOLIDINE-9-ALDEHYDE Property

Melting point:: 69-73°C
Boiling point:: 417.3±45.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 9.47±0.20(Predicted)
color: White to Amber to Dark green
InChI: InChI=1S/C13H15NO2/c15-8-10-7-9-3-1-5-14-6-2-4-11(12(9)14)13(10)16/h7-8,16H,1-6H2
InChIKey: NRZXBDYODHLZBF-UHFFFAOYSA-N
SMILES: C12=CC(C=O)=C(O)C3=C1N(CCC3)CCC2
CAS DataBase Reference: 63149-33-7(CAS DataBase Reference)
EPA Substance Registry System: 1H,5H-Benzo[ij]quinolizine-9-carboxaldehyde, 2,3,6,7-tetrahydro-8-hydroxy- (63149-33-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 404640
Product name: 2,3,6,7-Tetrahydro-8-hydroxy-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde
Purity: 98%
Packaging: 1g
Price: $119.45
Updated: 2025/07/31

TCI Chemical

Product number: H1225
Product name: 8-Hydroxyjulolidine-9-carboxaldehyde
Purity: >96.0%(GC)(T)
Packaging: 5g
Price: $197
Updated: 2025/07/31

AK Scientific

Product number: 9602AB
Product name: 8-Hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde
Packaging: 5g
Price: $241
Updated: 2021/12/16

ChemScene

Product number: CS-0060782
Product name: 8-Hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde
Packaging: 10g
Price: $244
Updated: 2021/12/16

ChemScene

Product number: CS-0060782
Product name: 8-Hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde
Packaging: 25g
Price: $488
Updated: 2021/12/16

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8-HYDROXYJULOLIDINE-9-ALDEHYDE Chemical Properties,Usage,Production

Uses

8-Hydroxyjulolidine-9-carboxaldehyde is a reactant in the development of iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc.

Synthesis

41175-50-2

68-12-2

63149-33-7

The general procedure for the synthesis of 8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-8-ol and N,N-dimethylformamide (DMF) to synthesize 8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carboxaldehyde was carried out in the following manner: at 4 °C, a flask containing 10 mL DMF was slowly charged dropwise with chlorine phosphorus oxide (2.7 mL, 4.4 g, 29 mmol), and the dropwise addition process lasted for 15 min. Subsequently, a solution of 8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol (5.15 g, 26.9 mmol) in DMF (5 mL) was added dropwise to the above mixture over 10 minutes. After dropwise addition, the reaction mixture was stirred at room temperature for 30 min, then warmed up to 100 °C and continued stirring for 30 min. Upon completion of the reaction, the mixture was cooled to room temperature and 30 mL of water was added to the stirring dark solution. The aqueous mixture was stirred for 1.5 hours until a blue-green precipitate formed. The precipitate was separated by filtration, washed with water and dried. The crude product was purified by silica gel column chromatography with an eluent of toluene/ethyl acetate (2:1 v/v). The final product yield was 94% and the melting point was 205°C (literature value 73-74°C).

References

[1] Chemical Communications, 2014, vol. 50, # 69, p. 9947 - 9950
[2] Journal of the American Chemical Society, 2003, vol. 125, # 16, p. 4708 - 4709
[3] Journal of Fluorescence, 2015, vol. 25, # 6, p. 1615 - 1628
[4] Organic Preparations and Procedures International, 2001, vol. 33, # 6, p. 603 - 613
[5] Journal of Organic Chemistry, 1987, vol. 52, # 8, p. 1465 - 1468

8-HYDROXYJULOLIDINE-9-ALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-HYDROXYJULOLIDINE-9-ALDEHYDE Suppliers

Americas 1 China 97 Europe 1 France 1 Germany 5 India 5 Japan 2 Russia 1 Switzerland 1 Ukraine 3 United Kingdom 1 United States 13 Global 131

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View Lastest Price from 8-HYDROXYJULOLIDINE-9-ALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 9-ForMyl-8-hydroxyjulolidine 63149-33-7
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Henan Fengda Chemical Co., Ltd

Product: 8-Hydroxyjulolidine-9-aldehyde 63149-33-7
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Career Henan Chemical Co

Product: 8-HYDROXYJULOLIDINE-9-ALDEHYDE 63149-33-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg
Release date: 2020-01-02

63149-33-7, 8-HYDROXYJULOLIDINE-9-ALDEHYDERelated Search:

8-Methoxyjulolidine 9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine Tetramethyljulolidine 1,1,7,7-TETRAMETHYL-2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ] QUINOLINE 2,3,6,7-Tetrahydro-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde Julolidine 8-HYDROXYJULOLIDINE 8-HYDROXYJULOLIDINE-9-ALDEHYDE

5h-benzo[ij]quinolizine-9-carboxaldehyde,2,3,6,7-tetrahydro-8-hydroxy-1

9-FORMYL-8-HYDROXYJULOLIDINE

9-FORMYL-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ]QUINOLIZIN-8-OL

8-HYDROXYJULOLIDINE-9-CARBOXALDEHYDE

8-HYDROXY-2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLINE-9-CARBALDEHYDE

8-HYDROXY-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[I,J]QUINOLIZINE-9-CARBOXALDEHYDE

AKOS NCG-0055

8-Hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde

2,3,6,7-TETRAHYDRO-8-HYDROXY-1H,5H-BENZO[I,J]QUINOLIZINE-9-CARBOXALDEHYDE

2,3,6,7-TETRAHYDRO-8-HYDROXY-1H,5H-BENZO[IJ]QUINOLIZINE-9-CARBALDEHYDE

2,3,6,7-Tetrahydro-10-hydroxy-1H,5H-benzo[ij]quinolizine-9-carbaldehyde

8-Hydroxy-2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizine-9-carbaldehyde

9-Formyl-8-julolidinol

9-Formyl-8-hydroxyjulolidine 2,3,6,7-Tetrahydro-8-hydroxy-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde

8-Hydroxyjulolidine-9-carboxaldehyde&gt

1H,5H-Benzo[ij]quinolizine-9-carboxaldehyde, 2,3,6,7-tetrahydro-8-hydroxy-

9-Formyl-8-hydroxyjulolidine, 97%,

8-hydroxyjulolodine-9-aldehyde

8-HYDROXYJULOLIDINE-9-ALDEHYDE

2,3,6,7-Tetrahydro-8-hydroxy-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde

6-hydroxy-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8-triene-7-carbaldehyde

63149-33-7

10547-59-4

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