2-Chloronicotinamide

Product Name: 2-Chloronicotinamide
CAS No.: 10366-35-5
Chemical Name: 2-Chloronicotinamide
Synonyms: 2-Chloronicotimide;TIMTEC-BB SBB004012;RARECHEM AH CK 0070;2-CHLORONICOTINAMIDE;2-CHLORONICOTINALDEHYDE;Nicotinamide, 2-chloro-;2-Chloronicotinamide 98%;2-Chloronicotinamide >2-CHLORONICOTINAMIDE CNAM;2-Chloronicotinamide, 98+%
CBNumber: CB9449716
Molecular Formula: C6H5ClN2O
Formula Weight: 156.57
MOL File: 10366-35-5.mol

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2-Chloronicotinamide Property

Melting point:: 164-167 °C(lit.)
Boiling point:: 313.7±27.0 °C(Predicted)
Density: 1.4411 (rough estimate)
refractive index: 1.5400 (estimate)
storage temp.: Inert atmosphere,Room Temperature
pka: 14.19±0.50(Predicted)
form: Fine Crystalline Powder
color: Beige
BRN: 119026
InChI: InChI=1S/C6H5ClN2O/c7-5-4(6(8)10)2-1-3-9-5/h1-3H,(H2,8,10)
InChIKey: ZQZAHPFFZWEUCL-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC=C1C(N)=O
CAS DataBase Reference: 10366-35-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1404
Product name: 2-Chloronicotinamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: C1404
Product name: 2-Chloronicotinamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $137
Updated: 2025/07/31

TRC

Product number: C380503
Product name: 2-Chloronicotinamide
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C380503
Product name: 2-Chloronicotinamide
Packaging: 5g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC142395
Product name: 2-Chloropyridine-3-carboxamide
Packaging: 50g
Price: $85
Updated: 2021/12/16

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2-Chloronicotinamide Chemical Properties,Usage,Production

Chemical Properties

BEIGE FINE CRYSTALLINE POWDER

Synthesis

6602-54-6

10366-35-5

General procedure for the synthesis of 2-chloronicotinamide from 2-chloro-3-cyanopyridine: 400 mL of concentrated sulfuric acid was added to a 1000 mL three-necked flask, followed by the addition of 2-chloro-3-cyanopyridine (138 g, 1 mol), which was stirred until completely dissolved. The reaction system was warmed up to 90 °C and the reaction was maintained at this temperature with stirring for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into a mixture containing 1000 mL of ammonia and 1 kg of ice and stirring was continued for 1 hour. The precipitated crude product was collected by filtration. The crude product was transferred to 1000 mL of ethyl acetate and stirred for 1 hour to wash and subsequently separated by filtration to give a white solid product. Finally, the white solid was dried by blowing at 50 °C to give 153 g of the intermediate 2-chloronicotinamide as a white solid in 98% yield.

References

[1] Patent: CN105367571, 2017, B. Location in patent: Paragraph 0014; 0037; 0038
[2] Tetrahedron Letters, 2012, vol. 53, # 4, p. 449 - 452
[3] Journal of Chemical Research, 2011, vol. 35, # 8, p. 480 - 483
[4] Synlett, 2018, vol. 29, # 15, p. 2061 - 2065
[5] Journal of Organic Chemistry, 1954, vol. 19, p. 1633,1636

2-Chloronicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloronicotinamide Suppliers

Americas 1 Belgium 2 China 142 Europe 3 France 2 Germany 8 India 14 Italy 1 Japan 3 South Korea 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 11 United States 25 Global 218

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View Lastest Price from 2-Chloronicotinamide manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Chloronicotinamide 10366-35-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-14

Dideu Industries Group Limited

Product: 2-Chloronicotinamide 10366-35-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloronicotinamide 10366-35-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

10366-35-5, 2-ChloronicotinamideRelated Search:

2-Chloronicotinyl chloride Nicotinamide 2-Chloronicotinic acid 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE 2,5-Dichloronicotinamide 6-CHLORONICOTINAMIDE N3-BENZYL-2-CHLORONICOTINAMIDE Nicotine N,N-DIMETHYLNICOTINAMIDE 2-Chloronicotinamide 2,6-DICHLORO-4-METHYLNICOTINAMIDE METHYL 2-[[(2-CHLORO-3-PYRIDYL)CARBONYL]AMINO]ACETATE (2S)-2-([(2-CHLOROPYRIDIN-3-YL)CARBONYL]AMINO)-4-(METHYLTHIO)BUTANOIC ACID 2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE N-(2-AMINOPHENYL)-2-CHLORONICOTINAMIDE N-allyl-2-chloronicotinamide N-allyl-6-chloronicotinamide N3-[3-(4-BROMO-1-METHYL-1H-PYRAZOL-3-YL)PHENYL]-2-CHLORONICOTINAMIDE

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10366-35-5

Halopyridines

Chloropyridines

Pyridines

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

amine|alkyl chloride

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

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Chloropyridines

Halopyridines