ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMOBENZONITRILE

2-AMINO-5-BROMOBENZONITRILE

Product Name: 2-AMINO-5-BROMOBENZONITRILE
CAS No.: 39263-32-6
Chemical Name: 2-AMINO-5-BROMOBENZONITRILE
Synonyms: 4-Bromo-2-cyanoaniline;5-Bromoanthranilonitrile;2-AMINO-5-BROMBENZONITRILE;2-amino-5-bromobenzoltrile;2-AMINO-5-BROMOBENZONITRILE;Benzonitrile, 2-amino-5-bromo-;2-Amino-5-bromobenzonitrile >2-AMINO-5-BROMOBENZONITRILE 97%;2-Amino-5-bromobenzonitrile,97%;2-Amino-5-bromobenzonitrile ,99%
CBNumber: CB9453843
Molecular Formula: C7H5BrN2
Formula Weight: 197.03
MOL File: 39263-32-6.mol

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2-AMINO-5-BROMOBENZONITRILE Property

Melting point:: 96-100 °C(lit.)
Boiling point:: 288.4±25.0 °C(Predicted)
Density: 1.6480 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Soluble in methanol.
pka: 1.11±0.10(Predicted)
form: Crystalline Powder
color: Off-white to pale brown
InChI: InChI=1S/C7H5BrN2/c8-6-1-2-7(10)5(3-6)4-9/h1-3H,10H2
InChIKey: OATYCBHROMXWJO-UHFFFAOYSA-N
SMILES: C(#N)C1=CC(Br)=CC=C1N
CAS DataBase Reference: 39263-32-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-43-36/37/38
Safety Statements: 36/37-36/37/39-26-22
RIDADR: 3439
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H331Toxic if inhaled

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1960
Product name: 2-Amino-5-bromobenzonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: A1960
Product name: 2-Amino-5-bromobenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $102
Updated: 2025/07/31

Cayman Chemical

Product number: 30454
Product name: 2-Amino-5-bromo-benzonitrile
Packaging: 500mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 30454
Product name: 2-Amino-5-bromo-benzonitrile
Packaging: 1g
Price: $50
Updated: 2024/03/01

TRC

Product number: A602505
Product name: 2-Amino-5-bromobenzonitrile
Packaging: 5g
Price: $60
Updated: 2021/12/16

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2-AMINO-5-BROMOBENZONITRILE Chemical Properties,Usage,Production

Description

2-Amino-5-bromo-benzonitrile is a heterocyclic building block. It has been used in the synthesis of copper-ligand coordination complexes and 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity.

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-5-bromobenzonitrile can react with Oxalic acid dimethyl ester to get 5-Bromo-N-methylanthranilonitrile.

Synthesis

1885-29-6

39263-32-6

The general procedure for the synthesis of 2-amino-5-bromobenzonitrile from 2-aminobenzonitrile was as follows: 2-aminobenzonitrile (11.8 g, 0.1 mol) was dissolved in acetic acid (120 ml) and ammonium bromide (10.3 g, 0.105 mol) and hydrogen peroxide (10.2 ml, 35% aqueous solution, 0.105 mol) were added sequentially. The reaction mixture was stirred at room temperature for about 1 hour, followed by continued stirring for 24 hours until LCMS analysis confirmed the completion of the reaction. Upon completion of the reaction, the acetic acid was removed by concentration and the residue was stirred with 30% aqueous sodium hydroxide solution to alkaline. The resulting solid was collected by filtration, washed with water and dried. The dried solid was dissolved in an excess of dichloromethane, the solution was concentrated until a precipitate began to appear and left to crystallize completely. The crystals were collected by filtration and washed with a small amount of dichloromethane to afford the target compound 2-amino-5-bromobenzonitrile as an off-white crystalline solid (19.2 g, 97% yield).1HNMR data: δ 7.61 (1H, d, J=2.5 Hz), 7.43 (1H, dd, J=9,2.5 Hz), 6.75 (1H, d, J=9 Hz), 6.28 ( 2H, br s); LC-MS retention time: 2.24 min.

References

[1] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 440 - 447
[2] Patent: WO2007/80401, 2007, A1. Location in patent: Page/Page column 26
[3] Synthetic Communications, 2010, vol. 40, # 6, p. 868 - 876
[4] Synthetic Communications, 2010, vol. 40, # 21, p. 3226 - 3232
[5] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 206, p. 205 - 221

2-AMINO-5-BROMOBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMOBENZONITRILE Suppliers

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View Lastest Price from 2-AMINO-5-BROMOBENZONITRILE manufacturers

Career Henan Chemical Co

Product: 2-AMINO-5-BROMOBENZONITRILE 39263-32-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

39263-32-6, 2-AMINO-5-BROMOBENZONITRILERelated Search:

2-AMINO-3,5-DIBROMOBENZONITRILE 2-AMINO-5-BROMOBENZONITRILE 4-Amino-3-bromobenzonitrile, GC 97%,4-AMINO-3-BROMOBENZONITRILE 97%,4-AMINO-3-BROMOBENZONITRILE 5-AMINO-2-BROMOBENZONITRILE,5-Amino-2-bromobenzonitrile 98% 2-AMINO-4-BROMOBENZONITRILE 4-Bromo-2-cyano-3-fluorophenylisothiocyanate 1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE 2-AMINO-5-BROMO-4-CHLOROBENZONITRILE 2-Amino-3,5-dibromo-6-chlorobenzonitrile 5-BROMO-2-NITROBENZONITRILE 2-AMINO-5-BROMO-3-CHLOROBENZONITRILE NO-1886 1-(4-BROMO-2-CYANOPHENYL)PIPERAZINE 2-Amino-5-bromo-3-(trifluoromethyl)benzonitrile 2-Amino-5-bromo-3-chloro-6-fluorobenzonitrile 2-AMINO-3,5-DIBROMO-6-FLUOROBENZONITRILE 2-Amino-5-bromo-3-iodobenzonitrile 2-Amino-5-bromo-6-fluoro-3-iodobenzonitrile

2-AMINO-5-BROMOBENZENECARBONITRILE

2-AMINO-5-BROMOBENZONITRILE

2-AMINO-5-BROMBENZONITRILE

4-Bromo-2-cyanoaniline

2-AMINO-5-BROMOBENZONITRILE 97%

5-Bromoanthranilonitrile

2-Amino-5-bromobenzonitrile,97%

2-Amino-5-bromobenzonitrile ,99%

4-Bromo-2-cyanoaniline 5-Bromoanthranilonitrile

2-Amino-5-bromophenyl-carbonitrile

2-Amino-5-bromobenzonitrile &gt

Benzonitrile, 2-amino-5-bromo-

39263-32-6 C7H5BrN2 2-AMINO-5-BROMOBENZONITRILE

2-amino-5-bromobenzoltrile

39263-32-6

392263-32-6

C7H5BrN2

C7H5N2Br

C6 to C7

Building Blocks

Cyanides/Nitriles

Organic Building Blocks

Nitrogen Compounds

FINE Chemical & INTERMEDIATES

Aromatic Nitriles

C6 to C7

Cyanides/Nitriles

Nitrogen Compounds

pharmacetical

Benzene nitrile

Anilines, Amides & Amines

Bromine Compounds

Nitriles