9-Phenylacridine
- Product Name
- 9-Phenylacridine
- CAS No.
- 602-56-2
- Chemical Name
- 9-Phenylacridine
- Synonyms
- 9-PA;phenylacridine;9-phenyl-acridin;9-PHENYLACRIDINE;9-Phenylacridine>Acridine, 9-phenyl-;9-Phenylacridin (9-PA);3-propan-2-yloxy-1-cyclohex-2-enone;TIANFU-CHEM CAS:602-56-2 9-Phenylacridine
- CBNumber
- CB9478127
- Molecular Formula
- C19H13N
- Formula Weight
- 255.31
- MOL File
- 602-56-2.mol
9-Phenylacridine Property
- Melting point:
- 184°C
- Boiling point:
- 388.54°C (rough estimate)
- Density
- 0.9418 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 5.45±0.10(Predicted)
- color
- Light yellow to Amber to Dark green
- InChI
- InChI=1S/C19H13N/c1-2-8-14(9-3-1)19-15-10-4-6-12-17(15)20-18-13-7-5-11-16(18)19/h1-13H
- InChIKey
- MTRFEWTWIPAXLG-UHFFFAOYSA-N
- SMILES
- C1C2C(=NC3C(C=2C2=CC=CC=C2)=CC=CC=3)C=CC=1
- CAS DataBase Reference
- 602-56-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Acridine, 9-phenyl-(602-56-2)
- EPA Substance Registry System
- Acridine, 9-phenyl- (602-56-2)
Safety
- Safety Statements
- 22-24/25
- HS Code
- 2933.99.8210
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P1198
- Product name
- 9-Phenylacridine
- Purity
- >98.0%(GC)
- Packaging
- 10g
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 42560
- Product name
- 9-Phenylacridine,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 10G
- Price
- $138.66
- Updated
- 2021/12/16
- Product number
- 100650
- Product name
- 9-Phenylacridine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- 8980AB
- Product name
- 9-Phenylacridine
- Packaging
- 25g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- 100650
- Product name
- 9-Phenylacridine
- Purity
- 95+%
- Packaging
- 100g
- Price
- $945
- Updated
- 2021/12/16
9-Phenylacridine Chemical Properties,Usage,Production
Uses
Research has found that 9-phenylacridine (ACPH) exhibited anticancer activity in cell lines and in vivo animal models. Bioinformatics studies have indicated that it could have topoisomerase I inhibitory activity. It could also act as a PARP 1 inhibitor and was very effective in combination with cisplatin in cell line-based assays. ACPH also satisfied all criteria for a candidate drug from the Lipinski rule and showed good cell uptake. ACPH alone was effective in the A375 melanoma cell line. ACPH could be used as a promising new photosensitizer[1-2]. 9-Phenylacridine is the parent base of chrysaniline or 3,6-diamino-9- phenylacridine, the chief constituent of the dyestuff phosphine. It is commonly used in the electronics industry as a free radical photoinitiator, significantly improving photo speed.
Description
9-Phenylacridine has antitumour activity. It can be used as a photosensitiser and can sensitise UVA-induced DNA damage in vitro and in cells. It also enhances cell killing by UVA. In addition. It is also used in photochemical research and as a raw material for organic synthesis.
Biological Activity
Hansda et al. suggested that a nontoxic dose of 9-Phenylacridine (ACPH) with UVA light can inhibit the proliferation of A375 cells by inducing DNA damage both in in vitro DNA and in cells through photosensitization. Such treatment enhanced the generation of ROS in cells, leading to lipid peroxidation and depletion of GSH. This led to cell cycle arrest at the G2/M phase to promote apoptosis through the mitochondria-mediated pathway. Although there was a slight increase in the small population of cells undergoing death through autophagy by UVA on ACPH pretreatment, primarily UVA+ACPH resulted in cell death through apoptosis. Thus, using ACPH as a photosensitizer in PDT may be contemplated. Applying ACPH topically to target cells and then illuminating them with UVA can minimize the concern of inducing damage to the surrounding normal cells [1].
References
[1] Surajit Hansda, Rita Ghosh, Gargi Ghosh. "9-phenyl acridine photosensitizes A375 cells to UVA radiation." Heliyon (2020): e04733.
[2] Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik. "9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells." Molecular and Cellular Biochemistry 361 1–2 (2012): 55–66.
9-Phenylacridine Preparation Products And Raw materials
Raw materials
Preparation Products
9-Phenylacridine Suppliers
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- --
- Fax
- --
- steffen.partzsch@allessasyntec.com
- Country
- Germany
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- Germany
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- Germany
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- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from 9-Phenylacridine manufacturers
- Product
- 9-Phenylacridine 602-56-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
- Product
- 9-Phenylacridine 602-56-2
- Price
- US $30.00-9.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 5 tons
- Release date
- 2023-11-16
- Product
- 9-Phenylacridine 602-56-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27