Methylprednisolone hemisuccinate

Description Synthesis

Product Name: Methylprednisolone hemisuccinate
CAS No.: 2921-57-5
Chemical Name: Methylprednisolone hemisuccinate
Synonyms: Methylprednisolone 21-Hemisuccinate;6α-Methylprednisolone 21-HeMisuccinate;6α-Methylprednisolone 21-HeMisuccinate;Methylprednisolone hydrogen succinate CRS;drogensuccinate);(6-alpha,11-beta)-yl;Methylprednisolone, Powder;methylprednisolonesuccinate;Methylprednisolone sucsinate;Methylprednisolone Impurity 15
CBNumber: CB9478132
Molecular Formula: C26H34O8
Formula Weight: 474.54
MOL File: 2921-57-5.mol

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Methylprednisolone hemisuccinate Property

Melting point:: >230°C (dec.)
Boiling point:: 689.6±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
pka: 4.29±0.17(Predicted)
form: Solid
color: White to Off-White
LogP: 2.69
CAS DataBase Reference: 2921-57-5(CAS DataBase Reference)

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Safety

HS Code: 2937290000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1437009
Product name: Methylprednisolone hemisuccinate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 250mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 11800
Product name: 6α-Methylprednisolone 21-hemisuccinate
Purity: ≥98%
Packaging: 10mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 11800
Product name: 6α-Methylprednisolone 21-hemisuccinate
Purity: ≥98%
Packaging: 25mg
Price: $57
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001759
Product name: Methylprednisolone hydrogen succinate for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001759
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: M1755220
Product name: Methylprednisolone hydrogen succinate for performance test
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: m1755220
Price: $60
Updated: 2024/03/01

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Methylprednisolone hemisuccinate Chemical Properties,Usage,Production

Description

Methylprednisolone hemisuccinate is a glucocorticoid used to treat severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal disorders, and endocrine disorders, among others.

Synthesis

Add 6L of dimethyl sulfoxide and 1kg of succinic anhydride in the reaction kettle, stir and dissolve at 25°C, add 0.8L of triethylamine, and stir for 10 minutes; add 1kg of methylprednisolone again, react at 30°C for 3 hours, add 10% hydrochloric acid water Terminate the reaction, separate 40 L of water, and stir for 30 minutes; filter and wash with water to obtain the crude product; the crude product is dissolved in 30 times of methanol temperature, and activated carbon is decolorized to obtain methylprednisolone succinate; the yield is 119%, and the content is 99.3%.

Chemical Properties

White or almost white, hygroscopic powder.

Uses

6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis.

Uses

Glucocorticoid.

Definition

ChEBI: Methylprednisolone succinate is a corticosteroid hormone and a hemisuccinate.

brand name

A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).

Methylprednisolone hemisuccinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methylprednisolone hemisuccinate Suppliers

Canada 1 China 150 Europe 2 Germany 1 India 17 Italy 1 South Korea 1 United Kingdom 5 United States 25 Global 203

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Email: jkinfo@jkchemical.com
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BOC Sciences

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BioBioPha Co., Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
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View Lastest Price from Methylprednisolone hemisuccinate manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: Methylprednisolone Hemisuccinate 2921-57-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-19

Hebei Mojin Biotechnology Co., Ltd

Product: Methylprednisolone Hemisuccinate 2921-57-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-05-19

Changzhou Rokechem Technology Co., Ltd.

Product: Methylprednisolone sodium hemisuccinate 2921-57-5
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%; CP/EP/USP
Supply Ability: 1-10000kgs
Release date: 2023-06-26

2921-57-5, Methylprednisolone hemisuccinateRelated Search:

Prednisolone Methylprednisolone D-α-Tocopherol succinate 6alpha-Methylprednisolone sodium succinate Methylprednisolone acetate Prednisolone-21-acetate Meprednisone Prednisone Methylprednisolone aceponate BECLOMETHASONE Hydrogen METHYLPREDNISOLONE HEMISUCCINATE USP(CRM STANDARD) Methylprednisolone hemisuccinate

6α-Methylprednisolone 21-HeMisuccinate

6-alpha-Methyl Isomer of Methylhydrocortisone 21-Hydrogen Succinate

11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-succinate

6a- methyl prednisolone acetate half Kohaku

Methylprednisolone 21-Hemisuccinate

6.alpha.-Methylprednisolone 21-hemisuccinate

4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hy

4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-suc

6-methylprednisolonehemisuccinate

Methylprednisolone sucsinate

Methylprednisolone Hemisuccinate (200 mg)

METHYLPRENISOLONE HEMISUCCINATE

4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid

Methylprednisolone hydrogen succinate for peak identification

Methylprednisolone sodium hemisuccinate

METHYLPREDNISOLONE 21-HEMISUCCINATE (6-ALPHA-METHYL ISOMER OF METHYLHYDROCORTISONE 21-HYDROGEN SUCCINATE)

Methylprednisolone Impurity 15

Methylprednisolone Hemisuccinate BP/USP/EP

MEGHYLPREDNISOLONE HEMISUCCINATE

METHYLPREDNISOLONEHEMISUCCINATE,USP

METHYLPREDNISOLONE HEMISNCCINATE

6A-METHYLPREDNISOLONEHEMISUCCINATE

Methylprednisolone, Powder

drogensuccinate)

methylprednisolonesuccinate

pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-meth

6 ALPHA-METHYLPREDNISOLONE HEMISUCCINATE

1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE

11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(hydrogen succinate)

METHYLPREDINISOLONE HEMISUCCINATE

(6-alpha,11-beta)-yl

METHYLPREDNISOLONE HEMISUCCINATE

11β,17α-Dihydroxy-3,20-dioxo-6α-methylpregna-1,4-diene-21-ol 21-(4-hydroxy-4-oxobutyrate)

21-(3-Carboxy-1-oxopropoxy)-11β,17-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

21-(3-Carboxy-1-oxopropoxy)-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione

Methylprednisolone hydrogen succinate CRS

Methylprednisolone hydrogen succinate for peak identification CRS

Methylprednisolone hydrogen succinate for performance test CRS

Methylprednisolone Succinate RS

Methylprednisolone 21-Hemisuccinate (Methylprednisolone Hydrogen Succinate)

Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6α,11β)-

Methylprednisolone Hemisuccinate USP/EP/BP

Methylprednisolone hydrogen succinateQ: What is Methylprednisolone hydrogen succinate Q: What is the CAS Number of Methylprednisolone hydrogen succinate Q: What are the applications of Methylprednisolone hydrogen succinate

6α-Methylprednisolone 21-HeMisuccinate

Methylprednisolone Hemisuccinate (1437009)

Methylprednisolone hemisuccinate Powder

Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6a,11b)-

Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6α,11β)-

1, 4-PREGNADIEN-6α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-HEMISUCCINATE

Methylprednisolone hydrogen hemisuccinate

2921-57-5

264368-56-0

C26H34O8

Steroid and Hormone

Steroids