ChemicalBook > CAS DataBase List > Methylprednisolone hemisuccinate
Methylprednisolone hemisuccinate
Description Synthesis- Product Name
- Methylprednisolone hemisuccinate
- CAS No.
- 2921-57-5
- Chemical Name
- Methylprednisolone hemisuccinate
- Synonyms
- Methylprednisolone 21-Hemisuccinate;6α-Methylprednisolone 21-HeMisuccinate;6α-Methylprednisolone 21-HeMisuccinate;Methylprednisolone hydrogen succinate CRS;drogensuccinate);(6-alpha,11-beta)-yl;Methylprednisolone, Powder;methylprednisolonesuccinate;Methylprednisolone sucsinate;Methylprednisolone Impurity 15
- CBNumber
- CB9478132
- Molecular Formula
- C26H34O8
- Formula Weight
- 474.54
- MOL File
- 2921-57-5.mol
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Methylprednisolone hemisuccinate Property
- Melting point:
- >230°C (dec.)
- Boiling point:
- 689.6±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
- pka
- 4.29±0.17(Predicted)
- color
- White to Off-White
- LogP
- 2.69
- CAS DataBase Reference
- 2921-57-5(CAS DataBase Reference)
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Safety
- HS Code
- 2937290000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 1437009
- Product name
- Methylprednisolone hemisuccinate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 250mg
- Price
- $436
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11800
- Product name
- 6α-Methylprednisolone 21-hemisuccinate
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $25
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11800
- Product name
- 6α-Methylprednisolone 21-hemisuccinate
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $57
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- Y0001759
- Product name
- Methylprednisolone hydrogen succinate for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001759
- Price
- $150
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- M1755220
- Product name
- Methylprednisolone hydrogen succinate for performance test
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- m1755220
- Price
- $60
- Updated
- 2024/03/01
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Methylprednisolone hemisuccinate Chemical Properties,Usage,Production
Description
Methylprednisolone hemisuccinate is a glucocorticoid used to treat severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal disorders, and endocrine disorders, among others.
Synthesis
Add 6L of dimethyl sulfoxide and 1kg of succinic anhydride in the reaction kettle, stir and dissolve at 25°C, add 0.8L of triethylamine, and stir for 10 minutes; add 1kg of methylprednisolone again, react at 30°C for 3 hours, add 10% hydrochloric acid water Terminate the reaction, separate 40 L of water, and stir for 30 minutes; filter and wash with water to obtain the crude product; the crude product is dissolved in 30 times of methanol temperature, and activated carbon is decolorized to obtain methylprednisolone succinate; the yield is 119%, and the content is 99.3%.
Chemical Properties
White or almost white, hygroscopic powder.
Uses
6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis.
Uses
Glucocorticoid.
Definition
ChEBI: Methylprednisolone succinate is a corticosteroid hormone and a hemisuccinate.
brand name
A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).
Methylprednisolone hemisuccinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methylprednisolone hemisuccinate manufacturers
Hebei Mojin Biotechnology Co., Ltd
- Product
- Methylprednisolone Hemisuccinate 2921-57-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19
Hebei Mojin Biotechnology Co., Ltd
- Product
- Methylprednisolone Hemisuccinate 2921-57-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-05-19
Changzhou Rokechem Technology Co., Ltd.
- Product
- Methylprednisolone sodium hemisuccinate 2921-57-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%; CP/EP/USP
- Supply Ability
- 1-10000kgs
- Release date
- 2023-06-26
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METHYLPREDNISOLONE HEMISUCCINATE USP(CRM STANDARD)
Methylprednisolone hemisuccinate