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Minoxidil sulphate

Application
Product Name
Minoxidil sulphate
CAS No.
83701-22-8
Chemical Name
Minoxidil sulphate
Synonyms
U-58838;MINOXIDIL SULFATE;MINOXIDIL SULPHATE;Minoxidil O-sulfate;minoxidilsulfateester;Minoxidil Sulphate INH;Sulfuric acid minoxidil;MINOXIDIL SUFATE ETHYLATED;Ketotifen Fumarate Tablets;Minoxidil sulfate (U-58838)
CBNumber
CB9494019
Molecular Formula
C9H15N5O4S
Formula Weight
289.31
MOL File
83701-22-8.mol
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Minoxidil sulphate Property

Melting point:
175-180°C
Density 
1.75±0.1 g/cm3(Predicted)
RTECS 
UV6260494
storage temp. 
-20°C
solubility 
Acetone (Slightly), DMSO (Slightly)
form 
White solid.
pka
-4.99±0.18(Predicted)
color 
White to Off-White
Stability:
Light Sensitive - Protect from Light, Store in Freezer
InChI
InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
InChIKey
AGMYAAIWWVATKU-UHFFFAOYSA-N
SMILES
C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1
CAS DataBase Reference
83701-22-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T+
Risk Statements 
22-36/37/38-26/27/28
Safety Statements 
26-36-45-36/37/39-22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M7920
Product name
Minoxidil sulfate salt
Packaging
1mg
Price
$42.9
Updated
2024/03/01
Sigma-Aldrich
Product number
M7920
Product name
Minoxidil sulfate salt
Packaging
5mg
Price
$195
Updated
2024/03/01
Alfa Aesar
Product number
J67021
Product name
Minoxidil sulfate, 98%
Packaging
5mg
Price
$128
Updated
2021/12/16
TRC
Product number
M345100
Product name
MinoxidilSulfate
Packaging
25mg
Price
$145
Updated
2021/12/16
TRC
Product number
M345100
Product name
MinoxidilSulfate
Packaging
50mg
Price
$275
Updated
2021/12/16
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Minoxidil sulphate Chemical Properties,Usage,Production

Application

Minoxidil sulfate was the drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp. The water solubility characteristics of minoxidil sulfate increases the absorption. 
Before that, minoxidil sulfate had been used as vasodilator drug prescribed as an oral tablet to treat high blood pressure and it’s can used for refractory hypertension and renal hypertension. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.

Chemical Properties

White Crystalline Solid

Uses

specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite

Uses

Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.

Uses

A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant

Biological Functions

Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.

Biochem/physiol Actions

Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.

in vitro

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.

Minoxidil sulphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Minoxidil sulphate Suppliers

Hubei Youyicheng Industrial Co., Ltd.
Tel
19521119694
Fax
86-027-87001826
Email
1572909019@qq.com
Country
China
ProdList
156
Advantage
58
Guangzhou Belka Biological Technology Co., Ltd.
Tel
+86-18665676617
Fax
18665676617
Country
China
ProdList
957
Advantage
58
Beri Pharma Co., Ltd.
Tel
13427714006
Email
sales@zhberi.com
Country
China
ProdList
31
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
Xi'an Kono chem co., Ltd.,
Tel
029-029-86107037-8012-8012 18729555803
Fax
15691813064
Email
sales9@konochemical.com
Country
China
ProdList
262
Advantage
58
Wuhan Yihe Technology Co., Ltd
Tel
1842-7358862 18427358864
Email
yihekeji@chembuying.com
Country
China
ProdList
823
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
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View Lastest Price from Minoxidil sulphate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Minoxidil sulphate 83701-22-8
Price
US $1000.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Minoxidil Sulfate/Minoxidil 83701-22-8
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Minoxidil sulphate 83701-22-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000 KGS
Release date
2021-06-18

83701-22-8, Minoxidil sulphateRelated Search:


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  • Minoxidil sulfate (U-58838)
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  • MINOXIDIL SUFATE ETHYLATED
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  • minoxidilsulfateester
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  • (Z)-2,2,2-trifluoro-1-(3-fluoropyridin-2-yl)ethanone oxiMe
  • Ketotifen Fumarate Tablets
  • Minoxidil sulphate USP/EP/BP
  • Minoxidil sulphateQ: What is Minoxidil sulphate Q: What is the CAS Number of Minoxidil sulphate Q: What is the storage condition of Minoxidil sulphate
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  • Minoxidil Sulfate/Minoxidil
  • 83701-22-8
  • 883701-22-8
  • C9H15N5O4S
  • C9H15N5OSO3
  • C9H17N5O5S
  • Voltage-gated Ion Channels
  • Potassium Channel Modulators
  • Ion Channels
  • Monovalent Ion Channels
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Other APIs
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals
  • APIs