Minoxidil sulphate

Application

Product Name: Minoxidil sulphate
CAS No.: 83701-22-8
Chemical Name: Minoxidil sulphate
Synonyms: U-58838;MINOXIDIL SULFATE;MINOXIDIL SULPHATE;Minoxidil O-sulfate;minoxidilsulfateester;Minoxidil Sulphate INH;Sulfuric acid minoxidil;MINOXIDIL SUFATE ETHYLATED;Ketotifen Fumarate Tablets;Minoxidil sulfate (U-58838)
CBNumber: CB9494019
Molecular Formula: C9H15N5O4S
Formula Weight: 289.31
MOL File: 83701-22-8.mol

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Minoxidil sulphate Property

Melting point:: 175-180°C
Density: 1.75±0.1 g/cm3(Predicted)
RTECS: UV6260494
storage temp.: -20°C
solubility: Acetone (Slightly), DMSO (Slightly)
form: White solid.
pka: -4.99±0.18(Predicted)
color: White to Off-White
Stability:: Light Sensitive - Protect from Light, Store in Freezer
InChI: InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
InChIKey: AGMYAAIWWVATKU-UHFFFAOYSA-N
SMILES: C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1
CAS DataBase Reference: 83701-22-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T+
Risk Statements: 22-36/37/38-26/27/28
Safety Statements: 26-36-45-36/37/39-22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M7920
Product name: Minoxidil sulfate salt
Packaging: 1mg
Price: $42.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: M7920
Product name: Minoxidil sulfate salt
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Alfa Aesar

Product number: J67021
Product name: Minoxidil sulfate, 98%
Packaging: 5mg
Price: $128
Updated: 2021/12/16

TRC

Product number: M345100
Product name: MinoxidilSulfate
Packaging: 25mg
Price: $145
Updated: 2021/12/16

TRC

Product number: M345100
Product name: MinoxidilSulfate
Packaging: 50mg
Price: $275
Updated: 2021/12/16

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Minoxidil sulphate Chemical Properties,Usage,Production

Application

Minoxidil sulfate was the drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp. The water solubility characteristics of minoxidil sulfate increases the absorption.

Before that, minoxidil sulfate had been used as vasodilator drug prescribed as an oral tablet to treat high blood pressure and it’s can used for refractory hypertension and renal hypertension. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.

Chemical Properties

White Crystalline Solid

Uses

specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite

Uses

Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.

Uses

A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant

Biological Functions

Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.

Biochem/physiol Actions

Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.

in vitro

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.

Minoxidil sulphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Minoxidil sulphate Suppliers

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View Lastest Price from Minoxidil sulphate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Minoxidil sulphate 83701-22-8
Price: US $1000.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-16

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Minoxidil sulphate 83701-22-8
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000 KGS
Release date: 2021-06-18

Baoji Guokang Bio-Technology Co., Ltd.

Product: Minoxidil sulphate 83701-22-8
Price: US $255.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 5T
Release date: 2021-06-03

83701-22-8, Minoxidil sulphateRelated Search:

FERROUS SULFATE SODIUM SULFATE Atropine sulfate Ferrous sulfate monohydrate Copper(II) sulfate Haloperidol Colistin sulfate Minoxidil D-Glucosamine sulfate 2,2,6,6-Tetramethylpiperidinooxy Potassium sulfate Ferric sulfate Ammonium sulfate Magnesium sulfate heptahydrate SULFATE STANDARD Albuterol sulfate Neomycin sulfate 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL

Sulfuric acid minoxidil

Minoxidil sulfate (U-58838)

6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATE

MINOXIDIL SULFATE

MINOXIDIL SULPHATE

U-58838

MINOXIDIL SUFATE ETHYLATED

1,6-Dihydro-6-iMino-4-(1-piperidinyl)-1-(sulfooxy)-

1,6-Dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-2-pyrimidinamine

Minoxidil O-sulfate

2-Pyrimidinamine, 1,6-dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-

minoxidilsulfateester

2,6-Diamino-4-(piperidin-1-yl)-pyrimidine 1-oxide sulfate

(Z)-2,2,2-trifluoro-1-(3-fluoropyridin-2-yl)ethanone oxiMe

Ketotifen Fumarate Tablets

Minoxidil sulphate USP/EP/BP

Minoxidil sulphateQ: What is Minoxidil sulphate Q: What is the CAS Number of Minoxidil sulphate Q: What is the storage condition of Minoxidil sulphate

Minoxidil Sulphate INH

83701-22-8

883701-22-8

C9H15N5O4S

C9H15N5OSO3

C9H17N5O5S

Voltage-gated Ion Channels

Potassium Channel Modulators

Ion Channels

Monovalent Ion Channels

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Other APIs

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites

Pharmaceuticals

APIs