ChemicalBook > CAS DataBase List > 4 7-DIMETHOXY-1-INDANONE 97

4 7-DIMETHOXY-1-INDANONE 97

Product Name
4 7-DIMETHOXY-1-INDANONE 97
CAS No.
52428-09-8
Chemical Name
4 7-DIMETHOXY-1-INDANONE 97
Synonyms
4,7-dimethoxy-1H-inden-1-one;4 7-DIMETHOXY-1-INDANONE 97;4,7-dimethoxyindan-1-one - [D86887];4,7-DIMETHOXY-2,3-DIHYDROINDEN-1-ONE;2,3-Dihydro-4,7-dimethoxy-1H-inden-1-one;4,7-DIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE;1H-Inden-1-one, 2,3-dihydro-4,7-dimethoxy-
CBNumber
CB9498633
Molecular Formula
C11H12O3
Formula Weight
192.21
MOL File
52428-09-8.mol
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4 7-DIMETHOXY-1-INDANONE 97 Property

Melting point:
122-125 °C (lit.)
Boiling point:
352.6±42.0 °C(Predicted)
Density 
1.179±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
Appearance
Light yellow to yellow Solid
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Safety

WGK Germany 
3
HS Code 
2914500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
578096
Product name
4,7-Dimethoxy-1-indanone
Purity
97%
Packaging
5g
Price
$617
Updated
2023/01/07
TRC
Product number
D470520
Product name
4,7-Dimethoxy-1-indanone
Packaging
5g
Price
$580
Updated
2021/12/16
TRC
Product number
D470520
Product name
4,7-Dimethoxy-1-indanone
Packaging
500mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
7401AB
Product name
4,7-Dimethoxy-2,3-dihydro-1H-inden-1-one
Packaging
1g
Price
$185
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078933
Product name
4,7-DIMETHOXY-1-INDANONE
Purity
95.00%
Packaging
5G
Price
$1322.48
Updated
2021/12/16
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4 7-DIMETHOXY-1-INDANONE 97 Chemical Properties,Usage,Production

Uses

4,7-Dimethoxy-1-indanone acts as a reagent for the synthesis and biological evaluation of indenopyrazine dicarbonitrile as inhibitors of deubiquitinating enzymes.

Definition

ChEBI: 4,7-dimethoxy-2,3-dihydroinden-1-one is a member of indanones.

Synthesis

10538-49-5

52428-09-8

The general procedure for the synthesis of 4,7-dimethoxy-1-indanone from 2,5-dimethoxybenzenepropanoic acid was as follows: a mixture of 2,5-dimethoxybenzenepropanoic acid (4.68 g, 22.3 mmol) and polyphosphoric acid (PPA, 50.87 g, 24.8 mL) was stirred and reacted for 4.0 h at 80°C. Upon completion of the reaction, the mixture was slowly poured into 250 mL of ice water and extracted with ethyl acetate (EtOAc, 100 mL x 5). The organic layers were combined, washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with petroleum ether/ethyl acetate (v/v = 3/1) as eluent to afford 4,7-dimethoxy-1-indanone as a light yellow solid (3.0 g, 70.0% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (MS, ESI) m/z: 193.2 [M + H]+; 1H NMR (400 MHz, CDCl3) δ 7.52 (s, 1H), 6.87 (s, 1H), 3.90 (s, 3H), 3.88 (s, 3H), 3.00-2.97 (m, 2H), 2.68- 2.65 (m, 2H).

References

[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 4, p. 1051 - 1057
[2] Patent: WO2014/82379, 2014, A1. Location in patent: Page/Page column 139; 140; 141
[3] Patent: EP2730572, 2015, B1. Location in patent: Paragraph 0259; 0261
[4] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994, vol. 30, # 8, p. 905 - 915
[5] Khimiya Geterotsiklicheskikh Soedinenii, 1993, # 8, p. 1052 - 1062

4 7-DIMETHOXY-1-INDANONE 97 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4 7-DIMETHOXY-1-INDANONE 97 manufacturers

Career Henan Chemical Co
Product
4 7-DIMETHOXY-1-INDANONE 97 52428-09-8
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

52428-09-8, 4 7-DIMETHOXY-1-INDANONE 97Related Search:

1-Indanone 4,7-DIMETHOXY-2-METHYL-INDAN-1-ONE 3-(2,5-DIMETHOXY-PHENYL)-PROPIONALDEHYDE 4-HYDROXY-7-METHOXYINDAN 7-HYDROXY-4-METHOXY-INDAN-1-ONE 4 7-DIMETHOXY-1-INDANONE 97 2-BROMO-2,3-DIHYDRO-4,7-DIMETHOXY-1H-INDEN-1-ONE 4-METHOXY-1-INDANONE 4-Hydroxyindan-1-one

  • 4 7-DIMETHOXY-1-INDANONE 97
  • 4,7-DIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE
  • 2,3-Dihydro-4,7-dimethoxy-1H-inden-1-one
  • 4,7-DIMETHOXY-2,3-DIHYDROINDEN-1-ONE
  • 4,7-dimethoxy-1H-inden-1-one
  • 1H-Inden-1-one, 2,3-dihydro-4,7-dimethoxy-
  • 4,7-dimethoxyindan-1-one - [D86887]
  • 52428-09-8
  • C11 to C12
  • Carbonyl Compounds
  • Ketones