4 7-DIMETHOXY-1-INDANONE 97
- Product Name
- 4 7-DIMETHOXY-1-INDANONE 97
- CAS No.
- 52428-09-8
- Chemical Name
- 4 7-DIMETHOXY-1-INDANONE 97
- Synonyms
- 4,7-dimethoxy-1H-inden-1-one;4 7-DIMETHOXY-1-INDANONE 97;4,7-dimethoxyindan-1-one - [D86887];4,7-DIMETHOXY-2,3-DIHYDROINDEN-1-ONE;2,3-Dihydro-4,7-dimethoxy-1H-inden-1-one;4,7-DIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE;1H-Inden-1-one, 2,3-dihydro-4,7-dimethoxy-
- CBNumber
- CB9498633
- Molecular Formula
- C11H12O3
- Formula Weight
- 192.21
- MOL File
- 52428-09-8.mol
4 7-DIMETHOXY-1-INDANONE 97 Property
- Melting point:
- 122-125 °C (lit.)
- Boiling point:
- 352.6±42.0 °C(Predicted)
- Density
- 1.179±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Light yellow to yellow Solid
Safety
- WGK Germany
- 3
- HS Code
- 2914500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 578096
- Product name
- 4,7-Dimethoxy-1-indanone
- Purity
- 97%
- Packaging
- 5g
- Price
- $617
- Updated
- 2023/01/07
- Product number
- D470520
- Product name
- 4,7-Dimethoxy-1-indanone
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- D470520
- Product name
- 4,7-Dimethoxy-1-indanone
- Packaging
- 5g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 7401AB
- Product name
- 4,7-Dimethoxy-2,3-dihydro-1H-inden-1-one
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- CHM0078933
- Product name
- 4,7-DIMETHOXY-1-INDANONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1322.48
- Updated
- 2021/12/16
4 7-DIMETHOXY-1-INDANONE 97 Chemical Properties,Usage,Production
Uses
4,7-Dimethoxy-1-indanone acts as a reagent for the synthesis and biological evaluation of indenopyrazine dicarbonitrile as inhibitors of deubiquitinating enzymes.
Definition
ChEBI: 4,7-dimethoxy-2,3-dihydroinden-1-one is a member of indanones.
Synthesis
10538-49-5
52428-09-8
The general procedure for the synthesis of 4,7-dimethoxy-1-indanone from 2,5-dimethoxybenzenepropanoic acid was as follows: a mixture of 2,5-dimethoxybenzenepropanoic acid (4.68 g, 22.3 mmol) and polyphosphoric acid (PPA, 50.87 g, 24.8 mL) was stirred and reacted for 4.0 h at 80°C. Upon completion of the reaction, the mixture was slowly poured into 250 mL of ice water and extracted with ethyl acetate (EtOAc, 100 mL x 5). The organic layers were combined, washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with petroleum ether/ethyl acetate (v/v = 3/1) as eluent to afford 4,7-dimethoxy-1-indanone as a light yellow solid (3.0 g, 70.0% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (MS, ESI) m/z: 193.2 [M + H]+; 1H NMR (400 MHz, CDCl3) δ 7.52 (s, 1H), 6.87 (s, 1H), 3.90 (s, 3H), 3.88 (s, 3H), 3.00-2.97 (m, 2H), 2.68- 2.65 (m, 2H).
References
[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 4, p. 1051 - 1057
[2] Patent: WO2014/82379, 2014, A1. Location in patent: Page/Page column 139; 140; 141
[3] Patent: EP2730572, 2015, B1. Location in patent: Paragraph 0259; 0261
[4] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994, vol. 30, # 8, p. 905 - 915
[5] Khimiya Geterotsiklicheskikh Soedinenii, 1993, # 8, p. 1052 - 1062
4 7-DIMETHOXY-1-INDANONE 97 Preparation Products And Raw materials
Raw materials
Preparation Products
4 7-DIMETHOXY-1-INDANONE 97 Suppliers
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- Switzerland
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View Lastest Price from 4 7-DIMETHOXY-1-INDANONE 97 manufacturers
- Product
- 4 7-DIMETHOXY-1-INDANONE 97 52428-09-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11