(S)-1-BOC-3-ACETAMIDOPYRROLIDINE

Product Name: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE
CAS No.: 114636-37-2
Chemical Name: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE
Synonyms: (S)-N-Boc-3-acetamidopyrrolidine;(S)-1-BOC-3-ACETYLAMINO PYRROLIDINE;(S)-(-)-1-BOC-3-ACETAMIDOPYRROLIDINE;(S)-N-Boc-3-acetamidopyrrolidine,99%e.e.;(S)-(?)-1-Boc-3-acetamidopyrrolidine;tert-Butyl (S)-3-acetamidopyrrolidine-1-carboxylate;(S)-tert-Butyl 3-acetaMidopyrrolidine-1-carboxylate;tert-butyl (3s)-3-acetamidopyrrolidine-1-carboxylate;TERT-BUTYL (3S)-3-(ACETYLAMINO)-1-PYRROLIDINECARBOXYLATE;1-Pyrrolidinecarboxylic acid, 3-(acetylamino)-, 1,1-dimethylethyl ester, (3S)-
CBNumber: CB9500381
Molecular Formula: C11H20N2O3
Formula Weight: 228.29
MOL File: 114636-37-2.mol

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(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Property

Melting point:: 86-90 °C
Boiling point:: 381.3±31.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.83±0.20(Predicted)
form: solid
optical activity: [α]20/D -18°, c = 3.5 in methanol

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 665088
Product name: (S)-(?)-1-Boc-3-acetamidopyrrolidine
Purity: 97%
Packaging: 5g
Price: $778
Updated: 2023/06/20

Sigma-Aldrich

Product number: 665088
Product name: (S)-(?)-1-Boc-3-acetamidopyrrolidine
Purity: 97%
Packaging: 1g
Price: $171
Updated: 2023/01/07

AK Scientific

Product number: Z2166
Product name: (S)-tert-Butyl3-acetamidopyrrolidine-1-carboxylate
Packaging: 5g
Price: $226
Updated: 2021/12/16

Activate Scientific

Product number: AS42494
Product name: 1-Boc-(S)-3-(acetamido)pyrrolidine
Purity: 97% ee
Packaging: 25g
Price: $783
Updated: 2021/12/16

AK Scientific

Product number: Z2166
Product name: (S)-tert-Butyl3-acetamidopyrrolidine-1-carboxylate
Packaging: 25g
Price: $838
Updated: 2021/12/16

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(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Chemical Properties,Usage,Production

Synthesis

108-24-7

147081-44-5

114636-37-2

Step 1: (S)-1-Boc-3-aminopyrrolidine (930 mg, 5 mmol) was dissolved in anhydrous dichloromethane (50 mL) and cooled to 0 °C. Subsequently, triethylamine (1.4 mL, 10 mmol) and acetic anhydride (567 μL, 6 mmol) were added sequentially. The reaction mixture was slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water (20 mL) and the organic layer was separated. The aqueous layer was extracted twice with dichloromethane (10 mL × 2). The combined organic layers were washed with brine (30 mL), dried over anhydrous sodium sulfate and concentrated. The crude product was purified by silica gel column chromatography to afford the target product S-1-Boc-3-N-acetylpyrrolidine (0.69 g, 60% yield).1H NMR (CDCl3, 400 MHz): δ 6.36-6.06 (br s, 1H), 4.45-4.36 (m, 1H), 3.68-3.48 (m, 1H), 3.43- 3.30 (m, 2H), 3.24-3.08 (m, 1H), 2.14-2.04 (m, 1H), 1.95 (s, 3H), 1.90-1.73 (m, 1H), 1.42 (s, 9H).

References

[1] Patent: WO2011/160020, 2011, A2. Location in patent: Page/Page column 68
[2] Patent: WO2006/64336, 2006, A2. Location in patent: Page/Page column 33

(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Suppliers

China 37 Germany 1 Switzerland 2 United Kingdom 1 United States 7 Global 48

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114636-37-2, (S)-1-BOC-3-ACETAMIDOPYRROLIDINERelated Search:

3-ACETAMIDOPYRROLIDINE (S)-1-BOC-3-ACETAMIDOPYRROLIDINE 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI) Phosphonium,[(3'S)-1'-[(1,1-dimethylethoxy)carbonyl]-2-oxo[1,3'-bipyrrolidin]-3-yl]triphenyl-,bromide (3S)-(-)-3-ACETAMIDOPYRROLIDINE

(S)-(-)-1-BOC-3-ACETAMIDOPYRROLIDINE

(S)-1-BOC-3-ACETYLAMINO PYRROLIDINE

TERT-BUTYL (3S)-3-(ACETYLAMINO)-1-PYRROLIDINECARBOXYLATE

(S)-tert-Butyl 3-acetaMidopyrrolidine-1-carboxylate

tert-Butyl (S)-3-acetamidopyrrolidine-1-carboxylate

(S)-N-Boc-3-acetamidopyrrolidine,99%e.e.

tert-butyl (3s)-3-acetamidopyrrolidine-1-carboxylate

(S)-N-Boc-3-acetamidopyrrolidine

1-Pyrrolidinecarboxylic acid, 3-(acetylamino)-, 1,1-dimethylethyl ester, (3S)-

(<i>S</i>)-(?)-1-Boc-3-acetamidopyrrolidine

114636-37-2