METHDILAZINE HYDROCHLORIDE (200 MG) Property

Melting point:

187.5-189°

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

Off-White to Pale Brown

Stability:

Air Sensitive, Hygroscopic

EPA Substance Registry System

Methdilazine hydrochloride (1229-35-2)

Safety

RIDADR 

UN 2811 6.1 / PGIII

HS Code 

2934302700

Hazardous Substances Data

1229-35-2(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 320 mg/kg (Goldenthal)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

METHDILAZINE HYDROCHLORIDE (200 MG) Chemical Properties,Usage,Production

Originator

Tacaryl ,Westwood,US,1960

Uses

Antipruritic.

Definition

ChEBI: Methdilazine hydrochloride is the hydrochloride salt of methdilazine. It contains a methdilazine.

Manufacturing Process

10.8 parts of 10-(1-methyl-3-pyrrolidylmethyl) phenothiazine (prepared from 1-methyl-3-pyrrolidylmethyl chloride by reaction with phenothiazine) in 80 parts of 99% isopropyl alcohol were treated with a solution of 1.33 parts of hydrogen chloride in 30 parts of the same solvent. The clear light yellow solution soon deposited white crystals of the acid addition salt. After cooling overnight at 0°C, the crystalline product was collected on a filter, washed with 99% isopropyl alcohol and anhydrous ether and then dried in a vacuum oven at 95°C. Yield 10.4 parts, MP 187.5° to 189°C.

brand name

Tacaryl (Westwood-Squibb).

Therapeutic Function

Antipruritic

General Description

Methdilazine hydrochloride(Tacaryl Hydrochloride), also occurs as a lighttancrystalline powder with a slight characteristic odor. Thesalt is freely soluble in water and in alcohol, however. Theactivity is like that of methdilazine, and it is administeredorally for its antipruritic effect.

General Description

White microcrystalline powder with a slight odor. pH (1% aqueous solution) 4.8-6.

Air & Water Reactions

Water soluble. pH (1% aqueous solution) 4.8-6 .

Reactivity Profile

METHDILAZINE HYDROCHLORIDE (200 MG) is sensitive to exposure to light. An acidic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Fire Hazard

Flash point data for METHDILAZINE HYDROCHLORIDE (200 MG) are not available; however, METHDILAZINE HYDROCHLORIDE (200 MG) is probably combustible.