3,N4-ETHENOCYTOSINE
- Product Name
- 3,N4-ETHENOCYTOSINE
- CAS No.
- 55662-66-3
- Chemical Name
- 3,N4-ETHENOCYTOSINE
- Synonyms
- 3,n(4)-ethanocytosine;imidazo[1,2-c]pyrimidin-5-ol;imidazo[1,2-f]pyrimidin-5-ol;IMidazo[1,2-c]pyriMidin-5(6H)-one
- CBNumber
- CB9503443
- Molecular Formula
- C6H5N3O
- Formula Weight
- 135.12
- MOL File
- 55662-66-3.mol
3,N4-ETHENOCYTOSINE Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.09±0.20(Predicted)
- Appearance
- Light brown to brown Solid
N-Bromosuccinimide Price
- Product number
- NUC0003911
- Product name
- 3,N4-ETHENOCYTOSINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.07
- Updated
- 2021/12/16
- Product number
- A123740
- Product name
- Imidazo[1,2-c]pyrimidin-5(6H)-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- A123740
- Product name
- Imidazo[1,2-c]pyrimidin-5(6H)-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CM253640
- Product name
- Imidazo[1,2-c]pyrimidin-5(6H)-one
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CM253640
- Product name
- Imidazo[1,2-c]pyrimidin-5(6H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
3,N4-ETHENOCYTOSINE Chemical Properties,Usage,Production
Definition
ChEBI: 3,N(4)-ethenocytosine is an organic heterobicyclic compound. It has a role as a mutagen. It is functionally related to a cytosine. It derives from a hydride of an imidazo[1,2-c]pyrimidine.
Synthesis
107-20-0
71-30-7
55662-66-3
Procedure for the synthesis of imidazo[1,2-c]pyrimidin-5(6H)-one (13): 50% aqueous chloroacetaldehyde (0.686 mL, 5.40 mmol) was added to a stirred solution of 6-aminopyrimidin-2(1H)-one (500 mg, 4.50 mmol) in N,N-dimethylformamide (DMF, 10 mL). The reaction mixture was stirred at 70 °C for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was washed with ethanol and ether to afford the target compound 13 as a light brown powder (320 mg, 53% yield). Thin layer chromatography (TLC) analysis showed Rf = 0.47 (unfolding agent: ethyl acetate/methanol, 4:1). The melting point of the product was 281-282 °C. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, [D6]DMSO): δ = 6.62 (d, 1H, 3J = 7.6 Hz), 7.28 (d, 1H, 3J = 7.6 Hz), 7.41 (d, 1H, 3J = 1.2 Hz), 7.80 (d, 1H, 3J = 1.2 Hz), 11.6 (bs, 1H). Nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, [D6]DMSO): δ = 97.7, 112.2, 129.4, 132.3, 145.9, 146.4. infrared spectrum (IR, KBr): ν = 3451, 3121, 3096, 1718, 1630, 1547, 1290, 1252, 1111 cm- 1. mass spectrum (ESI-MS): m/z 135.8 [M + H]+.
References
[1] Tetrahedron, 2014, vol. 71, # 1, p. 27 - 36
[2] Patent: WO2017/20944, 2017, A1. Location in patent: Page/Page column 16-17
3,N4-ETHENOCYTOSINE Preparation Products And Raw materials
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