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Cefpodoxime

Product Name
Cefpodoxime
CAS No.
80210-62-4
Chemical Name
Cefpodoxime
Synonyms
CPDX;Cefpodoxima;Cefpodoxime;Cefpodoximum;Unii-7R4F94tvgy;Cefpodoxime sulfate;Cefpodoximum [latin];Cefpodoxima [spanish];Cefpodoxime USP/EP/BP;Cefpodoxime tablet 200mg
CBNumber
CB9511604
Molecular Formula
C15H17N5O6S2
Formula Weight
427.46
MOL File
80210-62-4.mol
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Cefpodoxime Property

Melting point:
200-202°C
Density 
1.78±0.1 g/cm3(Predicted)
RTECS 
XI0367365
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO
pka
2.77±0.50(Predicted)
form 
Solid
color 
White to off-white
Sensitive 
Light Sensitive
BRN 
6021381
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
22-36/37-45
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
32344
Product name
Cefpodoxime
Purity
VETRANAL
Packaging
25mg
Price
$81.1
Updated
2024/03/01
Alfa Aesar
Product number
J66225
Product name
Cefpodoxime, 98%
Packaging
1g
Price
$394
Updated
2024/03/01
Cayman Chemical
Product number
16075
Product name
Cefpodoxime (free acid)
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16075
Product name
Cefpodoxime (free acid)
Purity
≥95%
Packaging
25mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
16075
Product name
Cefpodoxime (free acid)
Purity
≥95%
Packaging
50mg
Price
$121
Updated
2024/03/01
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Cefpodoxime Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A metabolite of Cefpodoxime Proxetil. An antibacterial.

Uses

Cefpodoxime Proxetil metabolite antibiotic

Uses

A metabolite of Cefpodoxime Proxetil (C243860). An antibacterial.

Definition

ChEBI: A third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis.

brand name

Vantin (Pharmacia & Upjohn).

Antimicrobial activity

It is stable to a wide range of plasmid-mediated β-lactamases. It induces the chromosomal β-lactamases of Ps. aeruginosa, Enterobacter spp., S. marcescens and Citrobacter spp., but is a less potent inducer than cefoxitin.

Biological Activity

cefpodoxime, as known as r 3763, is a metabolite of cefpodoxime proxetil. it is demonstrated that cefpodoxime, as an oral third generation cephalosporin antibiotic, is active against most gram-positive and gram-negative bacteria.cefpodoxime suppresses bacterial septum and cell wall synthesis by binding to penicillin-binding proteins (pbps) located in the bacterial cytoplasmic membrane.

Pharmacokinetics

Oral absorption: c. 50%
Cmax 200 mg oral: 2.1 mg/L after 3 h
Plasma half-life: c. 2.2 h
Volume of distribution: c. 35 L
Plasma protein binding: 20–30%
Absorption and distribution
The ester is rapidly hydrolyzed to the parent compound in the small intestine. Bioavailability increases to 65% if taken with food, but antacids and H2-receptor antagonists reduce absorption. Unabsorbed drug is hydrolyzed and excreted in the feces.
It is well distributed and penetrates well into tissues (including lung tissue) and inflammatory exudate to achieve concentrations inhibitory to common pathogens.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.

Clinical Use

Cefpodoxime has been used principally for the treatment of upper and lower respiratory tract infections in children and adults.

Side effects

The drug is well tolerated, but gastrointestinal disturbance with diarrhea is common. Pseudomembranous colitis has been reported occasionally. Other side effects are those common to cephalosporins.

in vitro

cefpodoxime showed antibacterial activities against obligatory anaerobes and salmonella spp., shigella spp. and neisseria meningitides. the activity of cefpodoxime was less active than r95867, an active form of cs-834, against gram-negative bacteria [1]. cefpodoxime was quite stable to hydrolysis by β-lactamases produced from b. cereus and e. coli hb101/pbr322 [2].

in vivo

male ddy mice were administered orally in a volume of 0.2 ml of 0.5% carboxymethyl cellulose sodium salt. after 7 days, it was shown that cefpodoxime had good efficacy against streptococcus spp. and k. pneumoniae infection in mice [1].

References

[1]. sakagawa, e., otsuki, m., oh, t., & nishino, t. in-vitro and in-vivo antibacterial activities of cs-834, a new oral carbapenem. journal of antimicrobial chemotherapy, 1998; 42: 426-437.
[2]. fukuoka, t., ohya, s., utsui, y., domon, h., takenouchi, t., koga, t., … kuwahara, s. in vitro and in vivo antibacterial activities of cs-834, a novel oral carbapenem. antimicrobial agents and chemotherapy, 1997; 41(12): 2652–2663.

Cefpodoxime Preparation Products And Raw materials

Raw materials

Preparation Products

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Cefpodoxime Suppliers

Canada 1 China 101 Germany 1 India 16 United Kingdom 6 United States 18 Global 143
Clearsynth Labs Limited
Tel
+91-22-26355700
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+91-22-26355701
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info@clearsynth.com
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India
ProdList
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58
CLEANCHEM LABORATORIES LLP
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sales4@cleanchemlab.com
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India
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325
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Triveni chemicals
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sales@trivenichemical.com
Country
India
ProdList
6088
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Pharma Affiliates
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Country
India
ProdList
6754
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58
Del Trade International
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solan@deltrade.in
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India
ProdList
35
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58
Anant Pharmaceuticals Pvt. ltd
Tel
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info@anantlabs.com
Country
India
ProdList
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G.C Chemie Pharmie Ltd.
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COVALENT LABORATORIES PRIVATE LIMITED
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KPS Chemicals & Pharmaceuticals
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Country
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Nectar Lifesciences Ltd. (NLL)
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sales@neclife.com
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India
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58
Clearsynth Labs
Tel
--
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Email
fo@clearsynth.com
Country
India
ProdList
3887
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58
Pharmaffiliates Analytics and Synthetics P. Ltd
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mktg@pharmaffiliates.com
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SynZeal Research Pvt Ltd
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6514
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View Lastest Price from Cefpodoxime manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Cefpodoxime 80210-62-4
Price
US $80.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
Shaanxi Dideu Medichem Co. Ltd
Product
Cefpodoxime 80210-62-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
300 MT
Release date
2020-05-23
Career Henan Chemical Co
Product
Cefpodoxime 80210-62-4
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

80210-62-4, CefpodoximeRelated Search:

MTT 2-Methyl-4-isothiazolin-3-one Fosthiazate Benzothiazole 2,2'-Dithiobis(benzothiazole) Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 1-CHLOROETHYL ISOPROPYL CARBONATE (JCC-1)(INTERMEDIATE OF CEFPODOXIME PROXETIL (BANAN)),1-chloroethyl isopropyl carbonate (intermediate of cefpodoxime proxetil) Cefotaxime sodium Cefotaxime Cefpodoxime Proxetil JPFa,CEFPODOXIME PROXETIL,Cefpodoxime-d3, Free Acid Cefpodoxime Ceftioxide CEFPODOXIME SODIUM Cefpodoxime acid CEFPODOXIME, FREE ACID Cefpodoxime Sodium Sterile

  • Cefpodoxime Proxetil impurity 1/Cefpodoxime Proxetil EP Impurity A/ Cefpodoxime Acid/(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cefpodoxime Proxetil EP Impurity A (Cefpodoxime Acid)
  • Cefpodoxime proxetil Impurity A:( (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid(Cefpodoxime Acid)
  • (6R,7R)-7α-[[(2-Aminothiazol-4-yl)[(Z)-methoxyimino]acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetyl]amino]-3-methoxymethylcepham-3-ene-4-carboxylic acid
  • CPDX
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, (6R-(6alpha,7beta(Z)))-
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  • Cefpodoxima [spanish]
  • Cefpodoximum
  • Cefpodoximum [latin]
  • Unii-7R4F94tvgy
  • (6R,7R)-7-{2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetamido}-3-(methoxymethyl)-3-cephem-4-carboxylate
  • Cefpodoxime sulfate
  • (6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cefpodoxime
  • (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cefpodoxime Proxetil Impurity 1(Cefpodoxime Proxetil EP Impurity A)
  • (6R,7R)-7α-[[(2-Amino-4-thiazolyl)[(Z)-methoxyimino]acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid
  • Cefpodoxime-D3Acid(98%,99Atom%D)
  • Cefpodoxime Proxetil EP Impurity A
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, (6R,7R)-
  • Cefpodoxime Proxetil Impurity 1（EP Impurity A）
  • Cefpodoxime USP/EP/BP
  • Cefpodoxime D3 AcidQ: What is Cefpodoxime D3 Acid Q: What is the CAS Number of Cefpodoxime D3 Acid Q: What is the storage condition of Cefpodoxime D3 Acid Q: What are the applications of Cefpodoxime D3 Acid
  • CefpodoximeAcidQ: What is CefpodoximeAcid Q: What is the CAS Number of CefpodoximeAcid Q: What is the storage condition of CefpodoximeAcid Q: What are the applications of CefpodoximeAcid
  • Cefpodoxime tablet 200mg
  • Cefpodoxime,Bacterial,gram-negative bacteria,R-3763,Cefpodoxime (free acid),Cefpodoxime acid,Antibiotic,R 3763,Inhibitor,R3763,gram-positive bacteria,inhibit
  • 80210-62-4
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