GLI1 antibody
Source Reactivity Background References- Product Name
- GLI1 antibody
- Chemical Name
- GLI1 antibody
- Synonyms
- GLI1 antibody;Mouse Monoclonal GLI1 Antibody
- CBNumber
- CB95630263
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb378809
- Product name
- Gli1 antibody
- Purity
- Immunogen affinity purified
- Packaging
- 100μL
- Price
- $399.5
- Updated
- 2021/12/16
- Product number
- orb10718
- Product name
- GLI1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb613702
- Product name
- GLI1 antibody
- Purity
- Antigen affinity chromatography using the immunizing peptide.
- Packaging
- 100μg
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- orb613759
- Product name
- GLI1 antibody
- Purity
- Antigen affinity chromatography using the immunizing peptide.
- Packaging
- 100μg
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- orb10718
- Product name
- GLI1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
GLI1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human
Background
GLI was first identified as a gene amplified in a malignant glioma capable of transforming primary cells in cooperation with adenovirus E1A. GLI belongs to the Krüppel family of zinc finger proteins that includes three mammalian GLI proteins: GLI1, GLI2, and GLI3. These GLI proteins are similar to the Drosophila homolog Cubitus interruptus and function as transcription factors activated by the Hedgehog signaling pathway. Hedgehog signaling plays an important role in animal development, and research studies have shown that this pathway is aberrantly activated in many types of cancers.GLI1 itself is a transcriptional target of the Hedgehog signaling pathway and is used as a marker of Hedgehog signaling activation in cancer research.
References
[1] Kinzler, K.W. et al. (1987) Science 236, 70-3.
[2] Ruppert, J.M. et al. (1991) Mol Cell Biol 11, 1724-8.
[3] Kinzler, K.W. et al. (1988) Nature 332, 371-4.
[4] Ingham, P.W. and McMahon, A.P. (2001) Genes Dev 15, 3059-3087.
[5] McMahon, A.P. et al. (2003) Curr Top Dev Biol 53, 1-114.
[6] Lee, J. et al. (1997) Development 124, 2537-2552.
[7] Dahmane, N. et al. (1997) Nature 389, 876-881.
[8] Dai, P. et al. (1999) J. Biol. Chem. 274, 8143-8152.
[9] Watkins, D.N. et al. (2003) Nature 422, 313-317.
[10] Karhadkar, S.S. et al. (2004) Nature 431, 707-712.
GLI1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
GLI1 antibody Suppliers
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