ChemicalBook > CAS DataBase List > Nebivolol hydrochloride

Nebivolol hydrochloride

Product Name
Nebivolol hydrochloride
CAS No.
152520-56-4
Chemical Name
Nebivolol hydrochloride
Synonyms
CS-496;D06622;R-67555;Nebilox;Nebilet;Lobivon;Bystolic;Nebivolo;Narbivolol;NEBIVOLOL HC
CBNumber
CB9649567
Molecular Formula
C22H26ClF2NO4
Formula Weight
441.9
MOL File
152520-56-4.mol
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Nebivolol hydrochloride Property

Melting point:
220-222°C
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white to off-white
Merck 
14,6432
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
3077
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N1915
Product name
Nebivolol hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$82.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1457833
Product name
Nebivolol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$2590
Updated
2024/03/01
TCI Chemical
Product number
N0954
Product name
Nebivolol Hydrochloride
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$71
Updated
2024/03/01
TCI Chemical
Product number
N0954
Product name
Nebivolol Hydrochloride
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$212
Updated
2024/03/01
Cayman Chemical
Product number
23660
Product name
Nebivolol (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
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Nebivolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

A ?-Adrenergic blocker. Used as an antihypertensive

Uses

Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.

Uses

Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM

Definition

ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.

Biological Activity

Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.

storage

Desiccate at RT

Nebivolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nebivolol hydrochloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Nebivolol hydrochloride 152520-56-4
Price
US $990.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Nebivolol hydrochloride 152520-56-4
Price
US $0.00/g
Min. Order
1g
Purity
98%-102%
Supply Ability
10KGS
Release date
2021-06-24
Shaanxi Dideu Medichem Co. Ltd
Product
Nebivolol hydrochloride 152520-56-4
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%
Supply Ability
2000tons
Release date
2019-12-27

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