Nebivolol hydrochloride

ChemicalBook > CAS DataBase List > Nebivolol hydrochloride

Nebivolol hydrochloride

Product Name: Nebivolol hydrochloride
CAS No.: 152520-56-4
Chemical Name: Nebivolol hydrochloride
Synonyms: CS-496;D06622;R-67555;Nebilox;Nebilet;Lobivon;Bystolic;Nebivolo;Narbivolol;NEBIVOLOL HC
CBNumber: CB9649567
Molecular Formula: C22H26ClF2NO4
Formula Weight: 441.9
MOL File: 152520-56-4.mol

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Nebivolol hydrochloride Property

Melting point:: 220-222°C
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
form: powder
color: white to off-white
Merck: 14,6432

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 60-61
RIDADR: 3077
WGK Germany: 3
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1915
Product name: Nebivolol hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $82.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1457833
Product name: Nebivolol hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150mg
Price: $2590
Updated: 2024/03/01

TCI Chemical

Product number: N0954
Product name: Nebivolol Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $71
Updated: 2024/03/01

TCI Chemical

Product number: N0954
Product name: Nebivolol Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $212
Updated: 2024/03/01

Cayman Chemical

Product number: 23660
Product name: Nebivolol (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

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Nebivolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

A ?-Adrenergic blocker. Used as an antihypertensive

Uses

Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.

Uses

Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM

Definition

ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.

Biological Activity

Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.

storage

Desiccate at RT

Nebivolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nebivolol hydrochloride manufacturers

Sigma Audley

Product: Nebivolol hydrochloride 152520-56-4
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-15

Shaanxi Dideu Medichem Co. Ltd

Product: Nebivolol hydrochloride 152520-56-4
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-27

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Nebivolol hydrochloride 152520-56-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-09

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Narbivolol

rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

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Nebivolol hydrochloride

NEBIVOLOL HC

R 065824 hydrochloride

CS-496

(169293-50-9) nebivolol hydrochloride

a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

(aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride

D06622

Nebivolol hydrochloride (usan)

(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

Nebivolol (Bystolic)

Nebivalate HCl

Bystolic

2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-(±)-

Nebivolol hydrochloride, 98%, a selective β1 antagonist

NebivololHydrochloride&gt

Nebivolol reference substance

Nebivolol hydrochloride USP/EP/BP

Nebivolol hydrochlorider

Nebivolol hydrochloride Impurities

Nebivolo

Nebivolol Hcl- IP

(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

Nebivolol HCl (R 065824)

R-Nebivolol D4 HCl

Nebivolol HydrochlorideQ: What is Nebivolol Hydrochloride Q: What is the CAS Number of Nebivolol Hydrochloride Q: What is the storage condition of Nebivolol Hydrochloride

TIANFU CHEM--Nebivolol hydrochloride

Nebivolol Hydrochloride (1457833)

2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α'R,2R,2'S)-rel-

(αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-Benzopyran-2-methanol hydrochloride (1:1)

Nebivolol hydrochloride (R-65824)

152520-56-4

C22H26ClF2NO4

C22H25F2NO4HCl

C22H25F2NO4ClH

C22H23O4F2NHCL

R-67145

API

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

152520-56-4