TIZOXANIDE

ChemicalBook > CAS DataBase List > TIZOXANIDE

Product Name: TIZOXANIDE
CAS No.: 173903-47-4
Chemical Name: TIZOXANIDE
Synonyms: TIZ;4-ABAH;NSC640;NSC 640;NSC-640;NSC 697856;TIZOXANIDE;Tizoxanide, >98%;Desacetyl-nitazoxanide;Nitazoxanide impurity 01
CBNumber: CB9649941
Molecular Formula: C10H7N3O4S
Formula Weight: 265.25
MOL File: 173903-47-4.mol

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TIZOXANIDE Property

Melting point:: 279-281°(dec)
Density: 1.644±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 6.70±0.50(Predicted)
color: Off-White to Pale Yellow

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Safety

HS Code: 2934.10.1000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3862
Product name: Tizoxanide
Packaging: 25MG
Price: $125
Updated: 2024/03/01

TCI Chemical

Product number: T3862
Product name: Tizoxanide
Packaging: 100MG
Price: $339
Updated: 2024/03/01

Cayman Chemical

Product number: 13693
Product name: Tizoxanide
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 13693
Product name: Tizoxanide
Purity: ≥95%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 13693
Product name: Tizoxanide
Purity: ≥95%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

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TIZOXANIDE Chemical Properties,Usage,Production

Description

Tizoxanide is an active metabolite of the antiparasitic nitazoxanide . Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 μg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC₅₀s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC₅₀s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC₅₀ = 0.15 μM for both).

Chemical Properties

Light Yellow Powder

Uses

A metabolite of Nitazoxanide; a potent inhibitor of hepatitis B virus and hepatitis C virus.

Uses

A metabolite of Nitazoxanide (N490100); a potent inhibitor of hepatitis B virus and hepatitis C virus. Kills Mycobacterium tuberculosis.

Definition

ChEBI: Desacetyl-nitazoxanide is a member of salicylamides.

in vitro

previous study found that tizoxanide showed potent inhibition of both hbv and hcv replication. tizoxanide also exhibited selective inhibition of intracellular hbv replication and extracellular virus production by 2.2.15 cells. tizoxanide could selectively reduce intracellular hcv replication in ava5 cells. moreover, the combination of tizoxanide with either recombinant human interferon alpha 2b (ifnα), or an ns5b (hcv polymerase) inhibitor, 2′-c-methyl cytidine, resulted in synergistic interactions against hcv replication. in addition, antiviral activities of tizoxanide against a full-length genotype 1a replicon were equivalent to that observed for ava5 cells [1].

in vivo

animal study in an immunosuppressed rat model suggested that relapses were less frequent after treatment with nitazoxanide, the parent drug of tizoxanide, than with the non-absorbable sinefungin and paromomycin [2].

IC 50

0.17 to 0.21 μm for civs

References

[1] korba be,montero ab,farrar k,gaye k,mukerjee s,ayers ms,rossignol jf. nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis b virus and hepatitis c virus replication. antiviral res.2008 jan;77(1):56-63.
[2] gargala g,delaunay a,li x,brasseur p,favennec l,ballet jj. efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against cryptosporidium parvum development in sporozoite-infected hct-8 enterocytic cells. j antimicrob chemother.2000 jul;46(1):57-60.

TIZOXANIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TIZOXANIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tizoxanide 173903-47-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tizoxanide 173903-47-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: TIZOXANIDE 173903-47-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

173903-47-4, TIZOXANIDERelated Search:

Nitazoxanide 2-Amino-5-nitrothiazole Nitazoxanide Impurity 2 Thiacloprid Thiamethoxam

TIZOXANIDE

2-hydroxy-N-(5-nitrothiazol-2-yl)benzaMide

Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)-

2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide

NSC 697856

TIZ

2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide

Tizoxanide, >98%

Nitazoxanide Desacetyl Impurity

Desacetyl-nitazoxanide

4-ABAH

NSC 640

NSC640

NSC-640

Desacetyl-nitazoxanide|||TIZ

Nitazoxanide impurity 01

173903-47-4

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