5-BROMO-2-METHANESULFONYL-PYRIMIDINE
- Product Name
- 5-BROMO-2-METHANESULFONYL-PYRIMIDINE
- CAS No.
- 38275-48-8
- Chemical Name
- 5-BROMO-2-METHANESULFONYL-PYRIMIDINE
- Synonyms
- NSC 262216;5-BROMO-2-METHANESULFONYL-PYRIMIDINE;5-Bromopyrimidin-2-yl methyl sulphone;Pyrimidine, 5-bromo-2-(methylsulfonyl)-;5-Bromo-2-(methylsulfonyl)pyrimidine 97%;5-
Bromo- 2- (methylsulfonyl) pyrimidine;5-BROMO-2-METHANESULFONYL-PYRIMIDINE ISO 9001：2015 REACH;5-Bromopyrimidin-2-yl methyl sulphone, 5-Bromo-2-(methylsulphonyl)-1,3-diazine - CBNumber
- CB9663127
- Molecular Formula
- C5H5BrN2O2S
- Formula Weight
- 237.07
- MOL File
- 38275-48-8.mol
5-BROMO-2-METHANESULFONYL-PYRIMIDINE Property
- Melting point:
- 130-133°C
- Boiling point:
- 393.7±34.0 °C(Predicted)
- Density
- 1.771±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline powder
- pka
- -4.78±0.22(Predicted)
- color
- White
- InChI
- InChI=1S/C5H5BrN2O2S/c1-11(9,10)5-7-2-4(6)3-8-5/h2-3H,1H3
- InChIKey
- MVIRMXABVKJKAR-UHFFFAOYSA-N
- SMILES
- C1(S(C)(=O)=O)=NC=C(Br)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 767093
- Product name
- 5-Bromo-2-(methylsulfonyl)pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $252
- Updated
- 2023/01/07
- Product number
- B678015
- Product name
- 5-Bromo-2-(methylsulphonyl)pyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB143269
- Product name
- 5-Bromo-2-(methylsulfonyl)pyrimidine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR15516
- Product name
- 5-Bromo-2-(methylsulphonyl)pyrimidine
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- 8H63-9-X4
- Product name
- 5-Bromo-2-(methylsulfonyl)pyrimidine
- Packaging
- 1g
- Price
- $82
- Updated
- 2021/12/16
5-BROMO-2-METHANESULFONYL-PYRIMIDINE Chemical Properties,Usage,Production
Synthesis
14001-67-3
38275-48-8
The general procedure for the synthesis of 5-bromo-2-(methylsulfonyl)pyrimidine from 5-bromo-2-methylmercaptopyrimidine was as follows: 5-bromo-2-methylthiopyrimidine (10.0 g, 48.8 mmol) was dissolved in methanol (195 mL), to which was subsequently added in batch and in an alternating addition pattern Oxone?(94.6 g, 154 mmol, 3.16 eq.) in an aqueous solution (500 mL) and 4N aqueous sodium hydroxide solution (40 mL, 160 mmol, 3.28 eq.), the temperature was controlled and the pH was maintained between 2 and 3 during the reaction. After the addition was completed, the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, water (500 mL) was added to dilute and the mixture was extracted with ethyl acetate (2 x 500 mL). The aqueous layer was adjusted to pH 7 and extracted again with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to afford 9.23 g (80% yield) of the target product, 5-bromo-2-(methylsulfonyl)pyrimidine, which could be used in the subsequent reaction without further purification. The product was characterized by 1H-NMR (300 MHz, DMSO-d6) and mass spectrometry (ESI): 1H-NMR δ 9.28 (s, 2H), 3.37 (s, 3H); MS (ESI): m/z [M + H]+ 237 (79Br).
References
[1] Patent: WO2008/155140, 2008, A1. Location in patent: Page/Page column 123-124
[2] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 137-138
5-BROMO-2-METHANESULFONYL-PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2-METHANESULFONYL-PYRIMIDINE manufacturers
- Product
- 5-BROMO-2-METHANESULFONYL-PYRIMIDINE 38275-48-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01