Dihydrostreptomycin
- Product Name
- Dihydrostreptomycin
- CAS No.
- 128-46-1
- Chemical Name
- Dihydrostreptomycin
- Synonyms
- DHSM;dhms;abiocine;vibriomycin;DIHYDROSTREPTOMYCIN;dihydro-streptomyci;DihydroestreptoMycin Sulfate;Benzimidazole, 2-cyanomethyl;dihydrostreptomycine sulphate;Dihydrostreptomycin USP/EP/BP
- CBNumber
- CB9665040
- Molecular Formula
- C21H41N7O12
- Formula Weight
- 583.59
- MOL File
- 128-46-1.mol
Dihydrostreptomycin Property
- Melting point:
- >300 °C
- Boiling point:
- 641.09°C (rough estimate)
- Density
- 1.3963 (rough estimate)
- refractive index
- 1.6800 (estimate)
- pka
- pKa 7.8 (Uncertain)
N-Bromosuccinimide Price
- Product number
- D8035
- Product name
- Dihydrostreptomycin
- Packaging
- 100g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 257286
- Product name
- Dihydrostreptomycin
- Packaging
- 50g
- Price
- $470
- Updated
- 2021/12/16
- Product number
- CHM0014251
- Product name
- DIHYDROSTREPTOMYCIN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1358.28
- Updated
- 2021/12/16
Dihydrostreptomycin Chemical Properties,Usage,Production
Description
Dihydrostreptomycin was first synthesized by Parke Davis Co. in 1946by the reduction of streptomycin. Naturally occurring dihydrostreptomycin was found in the culture broth of Streptomyces humidus by Takeda Chemicals Industries in 1957. Its hydrochloride or sulfate is more easily crystallized and more stable under alkaline conditions than streptomycin. Dihydrostreptomycin has been used for therapy of tuberculosis, but because it has a higher ototoxicity than streptomycin its use is now restricted to animal therapy.
Originator
Dihydrostrepto,MSD ,US,1948
Uses
Antibacterial.
Definition
ChEBI: Dihydrostreptomycin is a member of streptomycins.
Manufacturing Process
Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).
brand name
Abocillin;Biostrep;Complexobiotico;Diapenin 3;Diapenin balsamico;Diarrestival;Didromycin;Didrothenate;Dihydrocidan sulfato;Dihydrostreptofar;Diidro-pantostrept;Distreptopab;Dreiciclina balsamica;Dst;Entera-strept;Estreptoluy;Estreptosirup;Helle-strep-forte;Hp 48;Mastigun;Mixtencillin;Retromyopen;Rocopenstrep;Sanstrepto;Solmycin;Solvo-strept;Streptoduocin;Veticar;Veycil-as.
Therapeutic Function
Antibiotic
World Health Organization (WHO)
Dihydrostreptomycin, a derivative of the aminoglycoside antibiotic streptomycin with similar antibacterial activity, was first synthesized in 1947 and subsequently used in the treatment of tuberculosis and gram-negative infections. Preparations for systemic use have been widely withdrawn as a result of concern regarding their severe ototoxicity. Dihydrostreptomycin is poorly absorbed from the gastrointestinal tract. It remains available in oral preparations in some countries.
Safety Profile
Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormahties of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx
Dihydrostreptomycin Preparation Products And Raw materials
Raw materials
Preparation Products
Dihydrostreptomycin Suppliers
View Lastest Price from Dihydrostreptomycin manufacturers
- Product
- Dihydrostreptomycin 128-46-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-22
- Product
- Dihydrostreptomycin 128-46-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25