ChemicalBook > CAS DataBase List > 2-Methoxy-4-methylphenol

2-Methoxy-4-methylphenol

Product Name
2-Methoxy-4-methylphenol
CAS No.
93-51-6
Chemical Name
2-Methoxy-4-methylphenol
Synonyms
CREOSOL;4-METHYLGUAIACOL;Phenol, 2-methoxy-4-methyl-;4-Methyl-2-methoxyphenol;2-METHOXY-P-CRESOL;p-Methylguaiacol;VALSPICE;p-Creosol;Homocatechol methyl ester;kreosol
CBNumber
CB9667640
Molecular Formula
C8H10O2
Formula Weight
138.16
MOL File
93-51-6.mol
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2-Methoxy-4-methylphenol Property

Melting point:
5 °C (lit.)
Boiling point:
221-222 °C (lit.)
Density 
1.092 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.537(lit.)
FEMA 
2671 | 2-METHOXY-4-METHYLPHENOL
Flash point:
211 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
pka
10.27±0.18(Predicted)
form 
Liquid
color 
colorless to light yellow
Specific Gravity
1.091.092
Odor
at 10.00 % in dipropylene glycol. spicy clove vanilla phenolic medicinal leathery woody smoky burnt
Odor Type
spicy
Water Solubility 
Slightly soluble in water.
JECFA Number
715
Merck 
14,2571
BRN 
1862340
Dielectric constant
11.0
LogP
1.65
CAS DataBase Reference
93-51-6(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-methoxy-4-methyl-(93-51-6)
EPA Substance Registry System
Phenol, 2-methoxy-4-methyl- (93-51-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-24/25
RIDADR 
2810
WGK Germany 
3
RTECS 
GP1755000
F 
10
TSCA 
Yes
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29095090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W267112
Product name
2-Methoxy-4-methylphenol
Purity
natural, 97%, FG
Packaging
100g
Price
$319
Updated
2024/03/01
Sigma-Aldrich
Product number
W267112
Product name
2-Methoxy-4-methylphenol
Purity
natural, 97%, FG
Packaging
1kg
Price
$1650
Updated
2024/03/01
Sigma-Aldrich
Product number
W267104
Product name
2-Methoxy-4-methylphenol
Purity
≥98%, FG
Packaging
100g
Price
$72.7
Updated
2024/03/01
Sigma-Aldrich
Product number
W267104
Product name
2-Methoxy-4-methylphenol
Purity
≥98%, FG
Packaging
1kg
Price
$308
Updated
2024/03/01
Sigma-Aldrich
Product number
W267104
Product name
2-Methoxy-4-methylphenol
Purity
≥98%, FG
Packaging
10Kg
Price
$1870
Updated
2024/03/01
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2-Methoxy-4-methylphenol Chemical Properties,Usage,Production

Description

2-Methoxy-4-methylphenol has a characteristic aromatic odor (sweet, spicy, slightly vanilla-like) and a somewhat bitter taste (vanilla-like). May be prepared by methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.

Chemical Properties

2-Methoxy-4-methylphenol is a clear colorless to slightly yellow liquid or viscous, yeelowish oil, solidifying in the cold. The prismatic crystals melt at 6° C. Sp.Gr. 1.10. B.P. 222° C. Very slightly soluble in water, soluble in alcohol and oils. Sweet-spicy, phenolic-leathery odor with distinctly Vanilla-1ike undertones, balsamicwarm sweetness, but overall too medicinal to become classified as a versatile, floral-balsamic ingredient.

Occurrence

Occurs in beechwood tar; also identified in the essential oils of ylang-ylang, jasmine and anise seeds; it is one of the active constituents of creosote. Reported found in Gruyere cheese, smoked fish, cured pork, beer, rum, bourbon whiskey, malt and Scotch whiskey, sherry, white and red wine, cocoa, coffee, tea, mushrooms, mango, pear brandy, malt, wort, dried bonito, Bourbon vanilla, cuttlefish and green maté.

Uses

2-Methoxy-4-methylphenol is used for blending baking and smoked food flavors. Excellent additive and modifier in artificial Ylang-Ylang, Cassie-bases, Jasmin bases, Lily, Gardenia, etc. Finds use in flavor compositions for imitation Vanilla, Clove, various fruit compositions, Rum flavors, etc. and in Nut-Nougat flavor bases. Concentration will be about 0.02 to 1 ppm in the finished consumer product. In beverages, however, it may be as high as 10 to 20 ppm.

Definition

ChEBI: 2-Methoxy-4-methylphenol is a member of phenols and a member of methoxybenzenes. It is used in preparation of renewable bis(cyanate) esters.

Preparation

By methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.

Production Methods

With three distinct oxygenated functional groups (aldehyde, ether, and hydroxyl), VAN can undergo selective hydrodeoxygenation to produce 2- methoxy-4-methylphenol (MMP), a promising candidate for future biofuel applications and its use in fragrances and intermediate in pharmaceutical synthesis. Kumar et al. developed stable, cost-effective Ni nanoparticles supported on montmorillonite (MMT) clay, which was synthesized for eco-friendly, alcohol-mediated catalytic transfer hydrodeoxygenation of VAN to MMP. The Ni(10%)/MMT catalyst achieved >99% VAN conversion and 95.2% MMP selectivity using isopropanol (IPA) as a solvent and hydrogen donor[1].

References

[1] Atul Kumar, Prof. Dr. Rajendra Srivastava, Dr. Rajaram Bal. “Ni Nanoparticles Supported Montmorillonite Clay for Selective Catalytic Transfer Hydrodeoxygenation of Vanillin into 2-Methoxy-4-methylphenol.” ChemCatChem 16 9 (2024).

Aroma threshold values

Detection: 90 ppb. Aroma characteristics at 1.0%: smoky, sweet, phenolic, vanilla, spicy clove with a floral carnation nuance.

Taste threshold values

Taste characteristics at 1.0 to 1.25 ppm: sweet phenolic, spice, vanilla, medicinal, clove-like, smoky, guaia col-like with a woody, phenolic nuance.

General Description

2-Methoxy-4-methylphenol is the major component of black-ripe table olive aroma. It is the major anti-inflammatory compound in bamboo vinegar. Kinetics of reaction of 2-methoxy-4-methylphenol with chlorine atoms was studied.

Biochem/physiol Actions

Odor at 1.0%

2-Methoxy-4-methylphenol Preparation Products And Raw materials

Raw materials

4-Methylcatechol

Preparation Products

Catechol
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2-Methoxy-4-methylphenol Suppliers

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View Lastest Price from 2-Methoxy-4-methylphenol manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
2-Methoxy-4-methylphenol 93-51-6
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
2-Methoxy-4-methylphenol 93-51-6
Price
US $3900.00-3500.00/ton
Min. Order
0.0010000000474974513ton
Purity
99%
Supply Ability
5000
Release date
2024-08-09
Hebei Longbang Technology Co., Ltd
Product
2-methoxy-4-methylphenol 93-51-6
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-26

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