ChemicalBook > CAS DataBase List > Methyl N-Boc-piperidine-3-carboxylate

Methyl N-Boc-piperidine-3-carboxylate

Product Name
Methyl N-Boc-piperidine-3-carboxylate
CAS No.
148763-41-1
Chemical Name
Methyl N-Boc-piperidine-3-carboxylate
Synonyms
METHYL N-BOC-NIPECOTATE;N-Boc- Piperidine-3-carboxylate;N-Boc-nipecotic acid methyl ester;Methyl N-Boc-piperidine-3-carboxylate;N-Boc-piperidine-3-carboxylate Methyl;TERT-BUTYL METHYL PIPERIDINE-1,3-DICARBOXYLATE;1-Boc-3-piperidinecarboxylic Acid Methyl Ester;N-Boc-3-piperidinecarboxylic acid methyl ester;N-Boc-piperidine-3-carboxylic acid Methyl ester;REF DUPL: Methyl N-Boc-piperidine-3-carboxylate
CBNumber
CB9679283
Molecular Formula
C12H21NO4
Formula Weight
243.3
MOL File
148763-41-1.mol
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Methyl N-Boc-piperidine-3-carboxylate Property

Melting point:
47.0 to 51.0 °C
Boiling point:
307.4±35.0 °C(Predicted)
Density 
1.094±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-2.48±0.40(Predicted)
color 
White to Light yellow
InChI
InChI=1S/C12H21NO4/c1-12(2,3)17-11(15)13-7-5-6-9(8-13)10(14)16-4/h9H,5-8H2,1-4H3
InChIKey
LYYJQMCPEHXOEW-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCCC(C(OC)=O)C1
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2918
Product name
Methyl 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate
Purity
>98.0%(GC)
Packaging
5g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
M2918
Product name
Methyl 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate
Purity
>98.0%(GC)
Packaging
25g
Price
$96
Updated
2025/07/31
TRC
Product number
M294473
Product name
MethylN-Boc-piperidine-3-carboxylate
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
M294473
Product name
MethylN-Boc-piperidine-3-carboxylate
Packaging
100mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
455957
Product name
Methyl N-Boc-piperidine-3-carboxylate
Packaging
100mg
Price
$305
Updated
2021/12/16
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Methyl N-Boc-piperidine-3-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

71381-75-4

18107-18-1

148763-41-1

Trimethylsilylated diazomethane (14.18 ml, 2.0 M, 28.35 mmol) was added slowly and dropwise to a 20% methanol/toluene (100 ml) solution of 1-BOC-piperidine-3-carboxylic acid (5.00 g, 21.81 mmol) at room temperature. The reaction was monitored by thin layer chromatography (TLC) until the reaction was completed. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to afford methyl N-Boc-3-piperidinecarboxylate (Intermediate 53) 4.44 g in 83.7% yield. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δppm 1.4 (s, 9H), 1.6 (d, J = 3.4 Hz, 1H), 1.6 (m, 1H), 1.7 (m, 1H), 2.0 (m, 1H), 2.4 (m, 1H), 2.8 (m, 1H), 3.0 (s, 1H), 3.7 (s, 3H) , 3.9 (d, J13.2 Hz, 1H), 4.1 (s, 1H).

References

[1] Patent: US2006/116376, 2006, A1. Location in patent: Page/Page column 16
[2] Patent: WO2011/141728, 2011, A1. Location in patent: Page/Page column 19-20

Methyl N-Boc-piperidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl N-Boc-piperidine-3-carboxylate manufacturers

Wuhan Xinhao Biotechnology Co., Ltd
Product
Methyl N-Boc-piperidine-3-carboxylate 148763-41-1
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-03-12
Anhui Zhongda Biotechnology Co., Ltd
Product
Methyl N-Boc-piperidine-3-carboxylate 148763-41-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-10-26
Jinan Ande Pharmaceutical Co.,Ltd.
Product
Methyl N-Boc-piperidine-3-carboxylate 148763-41-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000
Release date
2021-12-20

148763-41-1, Methyl N-Boc-piperidine-3-carboxylateRelated Search:

Methyl acetate Methyl formate Methyl anthranilate Methyl 4-cyanobenzoate Methyl benzoate N-Boc-Piperidine-4-carboxylic acid methyl ester Kresoxim-methyl RESMETHRIN Methylparaben Nipecotic acid Methyl isonipecotate Tribenuron methyl METSULFURON METHYL Methyl carbamate Methyl salicylate Methyl acrylate Thiophanate-methyl Methyl

  • TERT-BUTYL METHYL PIPERIDINE-1,3-DICARBOXYLATE
  • METHYL N-BOC-NIPECOTATE
  • piperidine-1,3-dicarboxylic acid O1-tert-butyl ester O3-methyl ester
  • Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate
  • 1-TERT-BUTYL 3-METHYL PIPERIDINE-1,3-DICARBOXYLATE
  • N-Boc-nipecotic acid methyl ester
  • N-Boc- Piperidine-3-carboxylate
  • Methyl N-Boc-piperidine-3-carboxylate
  • REF DUPL: Methyl N-Boc-piperidine-3-carboxylate
  • N-Boc-piperidine-3-carboxylate Methyl
  • N-Boc-piperidine-3-carboxylic acid Methyl ester
  • 1-[(tert-butoxy)carbonyl]-2-Methylpiperidine-3-carboxylate
  • 1,3-Piperidinedicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester
  • N-Boc-Piperidine-3-carboxylate or 1-N-BOC-3-piperidinecarboxylic acid Methyl ester
  • Methyl 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate
  • 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid Methyl Ester
  • 1-Boc-3-piperidinecarboxylic Acid Methyl Ester
  • Piperidine-1,3-dicarboxylic Acid 1-tert-Butyl 3-Methyl
  • 1-(1,1-Dimethylethyl) 3-methyl 1,3-piperidinedicarboxylate
  • N-Boc-3-piperidinecarboxylic acid methyl ester
  • 1-(tert-Butyl) 3-methyl 1,3-piperidinedicarboxylate
  • 148763-41-1
  • 63-41-1