ChemicalBook > CAS DataBase List > 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

Product Name: 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
CAS No.: 83654-05-1
Chemical Name: 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
Synonyms: U-57908;Rg 80267;RHC-80267;RHC 80267, 10 mM in DMSO;RXSVYGIGWRDVQC-UHFFFAOYSA-N;RHC-80267 - CAS 83654-05-1 - Calbiochem;1,6-bis(cyclohexyloximinocarbonyl)hexane;RHC-80267, diacylglycerol lipase inhibitor;1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE;1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
CBNumber: CB9686432
Molecular Formula: C20H34N4O4
Formula Weight: 394.52
MOL File: 83654-05-1.mol

Less

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Property

Melting point:: 118-121℃
Density: 1.21±0.1 g/cm3(Predicted)
RTECS: GW1485000
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: 9 mg/mL
form: solid
pka: 13.81±0.46(Predicted)
color: white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R2028
Product name: RHC 80267
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $86.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 554994
Product name: RHC-80267
Packaging: 10mg
Price: $139
Updated: 2025/07/31

Cayman Chemical

Product number: 16432
Product name: RHC-80267
Purity: ≥95%
Packaging: 5mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 16432
Product name: RHC-80267
Purity: ≥95%
Packaging: 10mg
Price: $53
Updated: 2024/03/01

Sigma-Aldrich

Product number: R2028
Product name: RHC 80267
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $486
Updated: 2025/07/31

Less

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Chemical Properties,Usage,Production

Description

RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1

Uses

RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.

Definition

ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.

General Description

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biological Activity

Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).

Biochem/physiol Actions

Product does not compete with ATP.

storage

Store at +4°C

References

[1] PAUL W. MANLEY. Anthranilic Acid Amides: A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2002, 45 26: 5687-5693. DOI:10.1021/jm020899q
[2] PAUL WILLIAM MANLEY. Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2004, 1697 1: Pages 17-27. DOI:10.1016/j.bbapap.2003.11.010
[3] PAUL W. MANLEY. Anthranilic Acid Amides: A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2002, 45 26: 5687-5693. DOI:10.1021/jm020899q
[4] PAUL WILLIAM MANLEY. Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2004, 1697 1: Pages 17-27. DOI:10.1016/j.bbapap.2003.11.010
[5] PAUL W. MANLEY. Anthranilic Acid Amides: A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2002, 45 26: 5687-5693. DOI:10.1021/jm020899q

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Suppliers

China 85 Germany 1 Italy 1 Switzerland 3 United Kingdom 2 United States 15 Global 107

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD

Tel: 13816107857
Fax: qq: 276312098
Email: sales@fortunechem-sh.com
Country: China
ProdList: 984
Advantage: 58

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Changzhou Jiezhan Chemical Technology Co., Ltd

Tel: 15861130028; 15861130028
Email: 956912955@qq.com
Country: China
ProdList: 296
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15525
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Changzhou Xuanye Technology Co., Ltd

Tel: 15195022192
Email: 279776773@qq.com
Country: China
ProdList: 1996
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

Shaanxi Didu New Material Co., Ltd

Tel: 029-81145920 17391631969
Email: 1046@dideu.com
Country: China
ProdList: 9996
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Merck Millipore

Tel: 1-400-889-1988 400-889-1988
Email: bioscience@merckgroup.com
Country: China
ProdList: 6839
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8615965530500
Email: nickzhang@hangyubiotech.com
Country: China
ProdList: 8510
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Guangzhou Tangzhuang Biotechnology Co., Ltd.

Tel: 13432694097
Country: CHINA
ProdList: 158
Advantage: 58

Hangzhou Haofeng Biotechnology Co., Ltd.

Tel: 057186405477
Country: CHINA
ProdList: 184
Advantage: 58

Shanghai Hongmai Biotechnology Co., Ltd.

Tel: 400-920-5774
Country: CHINA
ProdList: 146
Advantage: 58

Guangzhou Suyan Biotechnology Co., Ltd

Tel: 18818417021
Country: CHINA
ProdList: 127
Advantage: 58

Guangzhou Haotian Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 122
Advantage: 58

Glacier Biotechnology (Shanghai) Co., Ltd

Tel: 18721971460
Country: CHINA
ProdList: 126
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

83654-05-1, 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANERelated Search:

Fatostatin A MK-886 EPOXOMICIN (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT N,N'-DIFORMYL-1,6-DIAMINOHEXANE 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Cyclohexanone oxime

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

RHC-80267

U-57908

N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine)

1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane

1,6-bis(cyclohexyloximinocarbonyl)hexane

1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908

RHC-80267 - CAS 83654-05-1 - Calbiochem

Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime

Rg 80267

O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone

RXSVYGIGWRDVQC-UHFFFAOYSA-N

(cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate

Cyclohexanone, 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime]

Cyclohexanone O-((6-((((cyclohexylideneamino)oxy)carbonyl)amino)hexyl)carbamoyl) oxime

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE ISO 9001：2015 REACH

RHC-80267, diacylglycerol lipase inhibitor

RHC 80267, 10 mM in DMSO

83654-05-1

C20H34N4O4

Biochemicals and Reagents

BioChemical

Enzymes, Inhibitors, and Substrates

Diacylglycerol kinase

D to K

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Lipid signaling