Pentafluoro-1-propanol Property

Boiling point:

80 °C748 mm Hg(lit.)

Density 

1.505 g/mL at 25 °C(lit.)

vapor pressure 

62.055-324.857hPa at 24.93-54.78℃

refractive index 

n20/D 1.288(lit.)

Flash point:

80-81°C

storage temp. 

Flammables area

pka

12.45±0.10(Predicted)

form 

Powder, Crystals and/or Chunks

Specific Gravity

1.509

color 

White to off-white to light yellow

Water Solubility 

Soluble in water.21.9 g/L at 25°C

BRN 

1743133

InChIKey

PSQZJKGXDGNDFP-UHFFFAOYSA-N

LogP

1.23

CAS DataBase Reference

422-05-9(CAS DataBase Reference)

NIST Chemistry Reference

2,2,3,3,3-Pentafluoro-1-propanol(422-05-9)

EPA Substance Registry System

1-Propanol, 2,2,3,3,3-pentafluoro- (422-05-9)

Safety

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-20-10

Safety Statements 

26-36-36/37/39-16

RIDADR 

1987

WGK Germany 

3

RTECS 

UB8800000

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29055900

Toxicity

LDLo orl-rat: 2250 mg/kg JOCMA7 4,262,62

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Pentafluoro-1-propanol Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2,2,3,3,3-Pentafluoro-1-Propanol is a useful reagent for the preparation of (oxoindolinyl)ethers/benzoates via photochemical O-H functionalization reactions of cyclic diazoamides.

Uses

2,2,3,3,3-Pentafluoro-1-propanol has been used:

• as derivatization reagent in detection of unlabeled and ¹⁵N₂ -labeled L-tryptophan, L-kynurenine, serotonin and quinolinic acid in human and rat plasma by GC-MS
• as derivatization reagent in simultaneous analysis of cocaine, cocaethylene and their possible metabolic and pyrolytic products in blood, urine and muscle by GC-MS
• preparation of trifluoromethyl ynamines which, in turn, converted aldehydes to α-trifluoromethyl-α,β-unsaturated amides
• to generate fluorinated α-keto ethers with alkenes and has wide applications in the expanding fluorous research area

General Description

2,2,3,3,3-Pentafluoro-1-propanol is an alternative cleaning agent for chlorofluorocarbon.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Fí.

Purification Methods

Shake the alcohol with alumina for 24hours, dry with anhydrous K2CO3, and distil it, collect the middle fraction (b 80-81o) and redistil it. [Beilstein 1 IV 1438.]