ChemicalBook > CAS DataBase List > GYKI 52466 HYDROCHLORIDE

GYKI 52466 HYDROCHLORIDE

Product Name
GYKI 52466 HYDROCHLORIDE
CAS No.
102771-26-6
Chemical Name
GYKI 52466 HYDROCHLORIDE
Synonyms
466;2466;CS-813;GYKI-5;GYKI52;GYKI 52;Gyki Hcl;gyki52466;GYKI52466HCl;Gyki Hydrochloride
CBNumber
CB9701780
Molecular Formula
C17H16ClN3O2
Formula Weight
329.78
MOL File
102771-26-6.mol
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GYKI 52466 HYDROCHLORIDE Property

Boiling point:
472.8±45.0 °C(Predicted)
Density 
1.39
storage temp. 
Desiccate at RT
solubility 
DMSO: 0.39 mg/mL
form 
solid
pka
8.14±0.20(Predicted)
color 
yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris
Product number
1454
Product name
GYKI52466dihydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$670
Updated
2021/12/16
Tocris
Product number
1454
Product name
GYKI52466dihydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$162
Updated
2021/12/16
Usbiological
Product number
255423
Product name
GYKI 52466 dihydrochloride
Packaging
10mg
Price
$403
Updated
2021/12/16
TRC
Product number
M303695
Product name
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine
Packaging
50mg
Price
$545
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
47448
Product name
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine
Packaging
10mg
Price
$620
Updated
2021/12/16
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GYKI 52466 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine is a non-competitive AMPA receptor antagonist and was found to have therapeutic potential for cocaine addiction treatment.

Definition

ChEBI: GYKI 52466 is a benzodiazepine.

Biological Activity

Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™ . Also available as part of the Kainate Receptor Tocriset™ .

storage

room temperature (desiccate)

GYKI 52466 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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GYKI 52466 HYDROCHLORIDE Suppliers

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102771-26-6, GYKI 52466 HYDROCHLORIDERelated Search:

Benzophenone hydrazone GYKI 52466 HYDROCHLORIDE ACETONE AZINE

  • gyki52466
  • 4-(8-METHYL-9H-1,3-DIOXOLO[4,5-H][2,3]BENZODIAZEPIN-5-YL)-BENZENAMINE HYDROCHLORIDE
  • GYKI 52466 HYDROCHLORIDE
  • 4-(8-Methyl-(9H)-1,3-dioxolo[4.5-h][2.3]benzodiazepine-5-yl)benzenaminehydrochloride
  • GYKI52466HCl
  • 1-(4-Aminophenyl)-4-methyl-7,8-(methylenedioxy)-5H-2,3-benzodiazepine
  • 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-5-yl)aniline
  • 1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
  • 4-(8-Methyl-9H-1,3-dioxolo(4,5-H)(2,3)benzodiazepin-5-yl)benzenamine
  • Benzenamine, 4-(8-methyl-9H-1,3-dioxolo(4,5-H)(2,3)benzodiazepin-5-yl)-
  • Gyki Hcl
  • 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenaminedihydrochloride
  • GYKI 52466 dihydrochloride
  • Gyki Hydrochloride
  • 4-(8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4,,5,:4,5]benzo[1,2-d][1,2]diazepin-5-yl)aniline
  • GYKI52466;GYKI-52466
  • CS-813
  • 2466
  • 466
  • GYKI 52
  • GYKI-5
  • GYKI52
  • GYKI 52466, Selective non-competitive AMPA antagonist
  • 102771-26-6
  • C17H15N3O22HCl
  • C17H15N3O2HCl
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals