ChemicalBook > CAS DataBase List > Chlorhexidine digluconate

Chlorhexidine digluconate

Product Name
Chlorhexidine digluconate
CAS No.
18472-51-0
Chemical Name
Chlorhexidine digluconate
Synonyms
CHLORHEXIDINE GLUCONATE;CHLOROHEXIDINE GLUCONATE;CHLORHEXIDINE GLUCONATE SOLUTION;chlorhexidine digluconate solution;CHLOROHEXIDINE DIGLUCONATE;D-Gluconic acid, compd. with N,N-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1);septeal;hibiclens;Periogard;CHLORHEIXIDINE GLUCONATE
CBNumber
CB9702888
Molecular Formula
C22H30Cl2N10.2C6H12O7
Formula Weight
897.76
MOL File
18472-51-0.mol
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Chlorhexidine digluconate Property

Density 
1.06 g/mL at 25 °C(lit.)
vapor pressure 
0.005Pa at 25℃
storage temp. 
2-8°C
solubility 
water: soluble50% (w/v)
form 
Liquid
color 
Colorless
Water Solubility 
750g/L at 20℃
λmax
257nm(H2O)(lit.)
Sensitive 
Light Sensitive
Merck 
14,2091
InChIKey
YZIYKJHYYHPJIB-UUPCJSQJSA-N
SMILES
N(C1C=CC(Cl)=CC=1)C(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1C=CC(Cl)=CC=1.[C@@H](O)([C@@H](O)C(=O)O)[C@H](O)[C@H](O)CO |&1:34,36,41,43,r|
LogP
-1.81 at 20.7℃
CAS DataBase Reference
18472-51-0(CAS DataBase Reference)
EPA Substance Registry System
Chlorhexidine gluconate (18472-51-0)
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
61
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
-
RTECS 
DU1950000
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29252900
Toxicity
LD50 in mice (mg/kg): 22 i.v.; 1800 orally (Foulkes)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C9394
Product name
Chlorhexidine digluconate solution
Purity
20% in H2O
Packaging
25ml
Price
$61.7
Updated
2024/03/01
Sigma-Aldrich
Product number
C9394
Product name
Chlorhexidine digluconate solution
Purity
20% in H2O
Packaging
100ml
Price
$162
Updated
2024/03/01
TCI Chemical
Product number
C3105
Product name
Chlorhexidine Digluconate (20% in Water)
Packaging
25mL
Price
$27
Updated
2024/03/01
Alfa Aesar
Product number
041385
Product name
Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile
Packaging
25ml
Price
$34.5
Updated
2024/03/01
Alfa Aesar
Product number
041385
Product name
Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile
Packaging
*4x500ml
Price
$628
Updated
2024/03/01
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Chlorhexidine digluconate Chemical Properties,Usage,Production

Description

Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

Chemical Properties

Almost colourless or pale-yellowish liquid.

Originator

Abacil,Polfa-Lodz SA,Poland

Uses

Hydrogenolysis of benzyl-nitrogen bonds. Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. It is used in hospitals to prevent infection of patients during surgeries and can also be found in mouthrinses.

Uses

Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. It is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.

Uses

chlorhexidine digluconate is a preservative generally used in concentrations of 0.01 to 0.1 percent to protect against bacteria. It is unstable at high temperatures. Chlorhexidine digluconate is more widely used in europe than in the united States.

Definition

ChEBI: Chlorhexidine gluconate is an organochlorine compound and a D-gluconate adduct. It has a role as an antibacterial agent. It is functionally related to a chlorhexidine.

Manufacturing Process

35 parts of hexamethylene bis-dicyandiamide, 35 parts of p-chloroaniline hydrochloride and 250 parts of β-etoxyethanol are stirred together at 130- 140°C for 2 hours under reflux. The mixture is then cooled and filtered. The solid is washed with water and crystallised from 50% aqueous acetic acid. 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) is obtained as colorless plates, melting point 258-260°C. By addition of D-gluconic acid to aqueous solution of chlorhexidine base is prepared 1,1'-hexamethylenebis(5-(pchlorophenyl)biguanide)digluconate (1:2).

brand name

Dyna-Hex (Xttrium); Hibiclens (Regent); Peridex (Zila); Periochip (Dexcel); Periogard (Colgate); Prevacare (Johnson & Johnson).

Therapeutic Function

Antiseptic

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Clinical Use

1,6-Di(4 -chlorophenyldiguanido)hexane gluconate (Hibiclens)is the most effective of a series of antibacterial biguanides originallydeveloped in Great Britain.
The antimicrobial properties of the biguanides were discoveredas a result of earlier testing of these compounds aspossible antimalarial agents. Although thebiguanides are technically not bisquaternary ammoniumcompounds and, therefore, should probably be classifiedseparately, they share many physical, chemical, and antimicrobialproperties with the cationic surfactants. Thebiguanides are strongly basic, and they exist as dications atphysiological pH. In chlorhexidine, the positive charges arecounterbalanced by gluconate anions (not shown). Likecationic surfactants, these undergo inactivation when mixedwith anionic detergents and complex anions such as phosphate,carbonate, and silicate.
Chlorhexidine has broad-spectrum antibacterial activitybut is not active against acid-fast bacteria, spores, orviruses. It has been used for such topical uses as preoperativeskin disinfection, wound irrigation, mouthwashes, andgeneral sanitization. Chlorhexidine is not absorbedthrough skin or mucous membranes and does not causesystemic toxicity.

Chlorhexidine digluconate Preparation Products And Raw materials

Raw materials

Preparation Products

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Chlorhexidine digluconate Suppliers

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View Lastest Price from Chlorhexidine digluconate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Chlorhexidine Gluconate 18472-51-0
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-04-19
hebei hongtan Biotechnology Co., Ltd
Product
Chlorhexidine gluconate/digluconate 18472-51-0
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-20
hebei hongtan Biotechnology Co., Ltd
Product
Chlorhexidine gluconate 18472-51-0
Price
US $20.00/L
Min. Order
1L
Purity
99%
Supply Ability
1000KG
Release date
2024-05-11

18472-51-0, Chlorhexidine digluconateRelated Search:

Chlorhexidine Diacetate Chlorhexidine Methylcyclohexane Chlorhexidine diacetate Hexane Cyclohexane D(+)-GLUCOSE MONOHYDRATE Gluconic acid D(+)-Glucose Calcium gluconate FERROUS GLUCONATE DIHYDRATE SODIUM GLUCOHEPTONATE D-Glucurone Glucose pentaacetate Glucose oxidase Ferrous gluconate Copper(II) gluconate D-(+)-Glucono-1,5-lactone Chlorhexidine Digluconate Solution

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