1H-Pyrazole-1-carboxamidine hydrochloride
- Product Name
- 1H-Pyrazole-1-carboxamidine hydrochloride
- CAS No.
- 4023-02-3
- Chemical Name
- 1H-Pyrazole-1-carboxamidine hydrochloride
- Synonyms
- 1H-pyrazole-1-carboximidamide;1-AMIDINOPYRAZOLE HYDROCHLORIDE;Praxadine;1H-pyrazole-1-carboxamidine;PYRAZOLE-1-CARBOXAMIDINE;Zanamivir EP Impurity F;Pyrazole-1-carboxamidine Hydrochloride;1H-PYRAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE;N-GUANYLPYRAZOLE;AMIDINOPYRAZOLE HCL
- CBNumber
- CB9707005
- Molecular Formula
- C4H7ClN4
- Formula Weight
- 146.58
- MOL File
- 4023-02-3.mol
1H-Pyrazole-1-carboxamidine hydrochloride Property
- Melting point:
- 167-170 °C(lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Crystals or Crystalline Powder
- color
- White to light yellow
- Water Solubility
- Soluble
- BRN
- 5448758
- InChI
- InChI=1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H
- InChIKey
- RBZRMBCLZMEYEH-UHFFFAOYSA-N
- SMILES
- N1(C(N)=N)C=CC=N1.[H]Cl
- CAS DataBase Reference
- 4023-02-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/37/38-36/37-34
- Safety Statements
- 26-37/39-45-36/37/39
- WGK Germany
- 3
- F
- 10-21
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- 402516
- Product name
- 1H-Pyrazole-1-carboxamidine hydrochloride
- Purity
- 99%
- Packaging
- 10g
- Price
- $52.84
- Updated
- 2025/07/31
- Product number
- Y0001703
- Product name
- Zanamivir impurity F
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10 mg
- Price
- $118
- Updated
- 2025/07/31
- Product number
- 402516
- Product name
- 1H-Pyrazole-1-carboxamidine hydrochloride
- Purity
- 99%
- Packaging
- 50g
- Price
- $204
- Updated
- 2025/07/31
- Product number
- A2055
- Product name
- 1-Amidinopyrazole Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- A2055
- Product name
- 1-Amidinopyrazole Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $83
- Updated
- 2025/07/31
1H-Pyrazole-1-carboxamidine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystals or crystalline
Uses
1H-Pyrazole-1-carboxamidine hydrochloride may be used in the following studies: ? Preparation of guanidylated hollow fiber membranes. ? Guanylation of amines and in peptide synthesis. ? Synthesis of bis-guanidinium-cholesterol derivatives.
Uses
1H-Pyrazole-1-carboxamidine hydrochloride is a stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. 1H-Pyrazole-1-carboxamidine hydrochloride is a useful reagent in peptide synthesis
General Description
1H-Pyrazole-1-carboxamidine hydrochloride, a pyrazole derivative, is a heterocyclic compound. It is widely used in drug syntheses studies. Pyrazole ring forms the main core of various nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs.
Synthesis
288-13-1
420-04-2
4023-02-3
Pyrazole (1.634 g, 24 mmol) and cyanamide (1 g, 24 mmol) were dissolved in 1,4-dioxane (24 mL), followed by the addition of 4 M hydrochloric acid (6 mL) to the 1,4-dioxane solution. The reaction mixture was stirred under reflux conditions for 1 hour. Upon completion of the reaction, the reaction mixture was placed in an ice-water bath and the product was induced to recrystallize by the addition of ether. The yield of the final product was 43%.
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 8, p. 2497 - 2502
[2] Organic Letters, 2004, vol. 6, # 26, p. 4925 - 4927
[3] Patent: KR101808950, 2017, B1. Location in patent: Paragraph 0233-0236
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 24, p. 2771 - 2774
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 812 - 820
1H-Pyrazole-1-carboxamidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrazole-1-carboxamidine hydrochloride Suppliers
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- info@acros.com
- Country
- Belgium
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View Lastest Price from 1H-Pyrazole-1-carboxamidine hydrochloride manufacturers
- Product
- 1H-Pyrazole-1-carboximidamide hydrochloride 4023-02-3
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- 1H-Pyrazole-1-carboxamidine hydrochloride 4023-02-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-20
- Product
- 1H-Pyrazole-1-carboxamidine hydrochloride 4023-02-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-23