ChemicalBook > CAS DataBase List > 1H-Pyrazole-1-carboxamidine hydrochloride

1H-Pyrazole-1-carboxamidine hydrochloride

Product Name
1H-Pyrazole-1-carboxamidine hydrochloride
CAS No.
4023-02-3
Chemical Name
1H-Pyrazole-1-carboxamidine hydrochloride
Synonyms
1H-pyrazole-1-carboximidamide;1-AMIDINOPYRAZOLE HYDROCHLORIDE;Praxadine;1H-pyrazole-1-carboxamidine;PYRAZOLE-1-CARBOXAMIDINE;Zanamivir EP Impurity F;Pyrazole-1-carboxamidine Hydrochloride;1H-PYRAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE;N-GUANYLPYRAZOLE;AMIDINOPYRAZOLE HCL
CBNumber
CB9707005
Molecular Formula
C4H7ClN4
Formula Weight
146.58
MOL File
4023-02-3.mol
More
Less

1H-Pyrazole-1-carboxamidine hydrochloride Property

Melting point:
167-170 °C(lit.)
storage temp. 
Inert atmosphere,Room Temperature
form 
Crystals or Crystalline Powder
color 
White to light yellow
Water Solubility 
Soluble
BRN 
5448758
InChI
InChI=1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H
InChIKey
RBZRMBCLZMEYEH-UHFFFAOYSA-N
SMILES
N1(C(N)=N)C=CC=N1.[H]Cl
CAS DataBase Reference
4023-02-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38-36/37-34
Safety Statements 
26-37/39-45-36/37/39
WGK Germany 
3
F 
10-21
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
402516
Product name
1H-Pyrazole-1-carboxamidine hydrochloride
Purity
99%
Packaging
10g
Price
$52.84
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001703
Product name
Zanamivir impurity F
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10 mg
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
402516
Product name
1H-Pyrazole-1-carboxamidine hydrochloride
Purity
99%
Packaging
50g
Price
$204
Updated
2025/07/31
TCI Chemical
Product number
A2055
Product name
1-Amidinopyrazole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
A2055
Product name
1-Amidinopyrazole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$83
Updated
2025/07/31
More
Less

1H-Pyrazole-1-carboxamidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystals or crystalline

Uses

1H-Pyrazole-1-carboxamidine hydrochloride may be used in the following studies: ? Preparation of guanidylated hollow fiber membranes. ? Guanylation of amines and in peptide synthesis. ? Synthesis of bis-guanidinium-cholesterol derivatives.

Uses

1H-Pyrazole-1-carboxamidine hydrochloride is a stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. 1H-Pyrazole-1-carboxamidine hydrochloride is a useful reagent in peptide synthesis

General Description

1H-Pyrazole-1-carboxamidine hydrochloride, a pyrazole derivative, is a heterocyclic compound. It is widely used in drug syntheses studies. Pyrazole ring forms the main core of various nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs.

Synthesis

288-13-1

420-04-2

4023-02-3

Pyrazole (1.634 g, 24 mmol) and cyanamide (1 g, 24 mmol) were dissolved in 1,4-dioxane (24 mL), followed by the addition of 4 M hydrochloric acid (6 mL) to the 1,4-dioxane solution. The reaction mixture was stirred under reflux conditions for 1 hour. Upon completion of the reaction, the reaction mixture was placed in an ice-water bath and the product was induced to recrystallize by the addition of ether. The yield of the final product was 43%.

References

[1] Journal of Organic Chemistry, 1992, vol. 57, # 8, p. 2497 - 2502
[2] Organic Letters, 2004, vol. 6, # 26, p. 4925 - 4927
[3] Patent: KR101808950, 2017, B1. Location in patent: Paragraph 0233-0236
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 24, p. 2771 - 2774
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 812 - 820

1H-Pyrazole-1-carboxamidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1H-Pyrazole-1-carboxamidine hydrochloride Suppliers

Americas 1 Belgium 1 Canada 1 China 271 Europe 1 France 1 Germany 3 India 6 Japan 4 Switzerland 4 The Netherlands 1 United Kingdom 9 United States 30 Global 333
Suzhou Highfine Biotech Co., Ltd
Tel
0512-69209928 18796809688
Fax
0512-68417696
Email
zhouyingxiang@highfine.com
Country
China
ProdList
475
Advantage
75
Nantong Zandery Biotechnology Co., Ltd.
Tel
0513-87582998 13912206938
Fax
+86 (513) 87581996
Email
xiaofeizhu@vip.163.com
Country
China
ProdList
252
Advantage
55
Nanjing Chemrui Pharmtech Co., Ltd.
Tel
25-25-58849758 13851795789
Fax
02558849768
Email
sales@chemrui.com
Country
China
ProdList
49
Advantage
62
Beijing Bainiannuan Sci.&Tec. Co., Ltd
Tel
13240490036
Fax
+86-10-51765262
Email
marymeng@bdnchem.com
Country
China
ProdList
35
Advantage
58
Liaoning bomei pharmaceutical technology co. LTD.
Tel
24-24524889 18640309171
Fax
+86-24-24524889
Email
236415745@qq.com
Country
China
ProdList
48
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
ShengXiong Biological Technology Development Co., Ltd.
Tel
86-021-64960112 13774219177
Fax
86-021-64960112
Email
alpha9196@gmail.com
Country
China
ProdList
52
Advantage
65
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
ChangZhou SIDU chemical Co., Ltd.
Tel
0519-81291281 18015082300
Fax
0519-81291281
Email
siduchem@hotmail.com
Country
China
ProdList
274
Advantage
62
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
DaLian Maijin Technology Co.,Ltd.
Tel
+86-411-39215997 13804269637
Fax
+86-411-39215997
Country
China
ProdList
49
Advantage
62
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
More
Less

View Lastest Price from 1H-Pyrazole-1-carboxamidine hydrochloride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1H-Pyrazole-1-carboximidamide hydrochloride 4023-02-3
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-09-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
1H-Pyrazole-1-carboxamidine hydrochloride 4023-02-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Henan Aochuang Chemical Co.,Ltd.
Product
1H-Pyrazole-1-carboxamidine hydrochloride 4023-02-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-23

4023-02-3, 1H-Pyrazole-1-carboxamidine hydrochlorideRelated Search:

ZANAMIVIR HYDRATE 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Topotecan hydrochloride Pyraclostrobin Pyrazole Zolpidem tartrate Zanamivir Azide Methyl Ester N-Cyano Zanamivir Amine Triacetate Methyl Ester Zanamivir D-GLYCERO-D-GALACTO-NON-2-ENONIC ACID Zanamivir Amine Formamidine hydrochloride Zolpidem N''1-METHYL-1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE 1H-Pyrazole-1-carboxamidine hydrochloride 3,5-DIMETHYL-1-1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE N(sup 4)-2-Propenylpyrazolo(1,5-a)-1,3,5-triazine-2,4-diamine, hydroch loride hydrate (2:2:1) 5-CHLORO-4-([2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]SULFONYL)-1,3-DIMETHYL-1H-PYRAZOLE

  • 1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE
  • 1H-PYRAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE
  • 1H-PYRAZOLE-1-CARBAMIDINE HCL
  • 1-AMIDINOPYRAZOLE HYDROCHLORIDE
  • 1-AMIDINOPYRAZOLE MONOHYDROCHLORIDE
  • PYRAZOLE CARBOXAMIDINE HCL
  • 1H-Pyrazole-1-carboxaMidine Monohydrochloride, 99% 10GR
  • 1H-Pyrazole-1-carboxaMidine Monohydrochloride, 99% 50GR
  • AMIDINOPYRAZOLE HCL
  • Praxadine 1-Pyrazolecarboxamidine Hydrochloride
  • Pyrazole-1-benzaMidineHCl
  • 1H-Pyrazole-1-carboxaMidine hydrochloride 99%
  • 1 h - pyrazole - 1 - a aMidine hydrochloride
  • 1H-Pyrazole-1-carboxamidine hydrochloride 1-Amidinopyrazole hydrochloride
  • 1H-Pyrazole-1-carboximidamide HCl
  • 1H-Pyrazole-1-carboximidamide hydrochloride, 1-Carbamimidoyl-1H-pyrazole hydrochloride
  • Zanamivir impurity F
  • 1H-Pyrazole-1-carboximidamide,hydrochloride (1:1)
  • 1-AMIDINOPYRAZOLE MONOHYDROCHL
  • TIMTEC-BB SBB004101
  • Praxadine
  • (1H)-Pyrazole-1-carboxamidineHCl
  • PYRAZOLE-1-CARBOXAMIDINE
  • N-GUANYLPYRAZOLE
  • PRAXADINE HYDROCHLORIDE
  • Zanamivir Intermediate 1
  • monohydrochloride 1-Pyrazolecarboxamidine Hydrochloride
  • 1H-Pyrazole-1-carboxamidine hydrochloride ,99%
  • 1H-Pyrazole-1-carboxamidine hydrochloride,1-Amidinopyrazole hydrochloride, Praxadine
  • 1H-Pyrazole-1-carboxamidine monohydrochloride,99%
  • 1h-pyrazole-1-carboxamidehydrochloride
  • 1H-Pyrazole-carboxamidineHCl
  • Pyrazole-1-carboxamidine Hydrochloride
  • 1H-pyrazole-1-carboximidamide
  • 1H-PYRAZOLE-1-CARBOXIMIDAMIDEHYDROCHLORIDE
  • 1H-Pyrazole-1-carboximidamidemonohydrochloride
  • 1H-PYRAZOLE-1-CARBOXAMIDINE, HYDROCHLORIDE 98+%
  • 1H-pyrazole-1-carboxamidine
  • 1H-PYRAZOLE-1-CARBAMIDINE HCI
  • 1-Pyrazolecarboxamidine Hydrochloride
  • 1-Amidinopyrazole hydrochloride, Praxadine
  • 1-Carbamimidoylpyrazole Hydrochloride
  • e-1-carboxamidine hydrochL
  • Zanamivir impurity F CRS
  • 1-Amidinopyrazole Hydrochloride &gt
  • Zanamivir EP Impurity F
  • Zanamivir Impurity 6(Zanamivir EP Impurity F)
  • Pyrazole-1-carboximidamide Hydrochloride
  • 1H-Pyrazole-1-carboxamidine hydrochloride ISO 9001：2015 REACH
  • 1H-pyrazol-1-ium-1-carboximidamide
  • TIANFUCHEM--4023-02-3--1H-Pyrazole-1-carboxamidine hydrochloride factory price
  • 1H-Pyrazole-1-methylamidine hydrochloride
  • 1-H-Pyrazol-1-carboxamidine hydrochloride
  • 1H-Pyrazole-1-carboximidamide hydrochloride (Zanamivir Impurity)
  • Zanamivir EP Impurity F(HCl)
  • pyrazole-1-carboxamidine monohydrochloride
  • 1<i>H</i>-Pyrazole-1-carboxamidine hydrochloride
  • 1H-Pyrazol-1-carboximidamide HCl