α-Chloralose Property

Melting point:

178-182 °C

alpha 

18 º (c=2, 95% C2H5OH)

Boiling point:

424.33°C (rough estimate)

Density 

1.6066 (rough estimate)

vapor pressure 

Negligible at room temperature

refractive index 

1.5320 (estimate)

solubility 

ethanol: 10 mg/mL or yellow-brown, clear to slightly hazy, colorless to faintly yellow

pka

12.89±0.60(Predicted)

form 

Solid

color 

White to Almost white

optical activity

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

Water Solubility 

0.44 g/100 mL (15 ºC)

Merck 

14,2072

BRN 

85418

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

1.020

CAS DataBase Reference

15879-93-3(CAS DataBase Reference)

EPA Substance Registry System

Chloralose (15879-93-3)

Safety

Hazard Codes 

Xn

Risk Statements 

20/22-20/21/22

Safety Statements 

16-24/25-28-28A-36

RIDADR 

3249

WGK Germany 

1

RTECS 

FM9450000

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29400090

Toxicity

LD50 orally in mice: 400 mg/kg (Schafer)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H332Harmful if inhaled

H336May cause drowsiness or dizziness

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

α-Chloralose Chemical Properties,Usage,Production

Description

Chloralose, (R)-1,2-O-(2,2,2-trichloroethylidene)- α-D-glucofuranose, is a crystalline powder which is soluble in water, fairly soluble in alcohol, diethyl ether, glacial acetic acid, sparingly soluble in chloroform, practically insoluble in petroleum ether.
Chloralose is produced by reaction of glucose with waterfree chloral under heating (21).

Chemical Properties

needle-like crystals or powder

Uses

Coating seeds to protect them from birds.

Uses

It has been employed widely as an animal anesthetic in the laboratory setting. alpha-chloralose is a true anesthetic or an immobilizing agent with sedative-hypnotic properties has important implications. Canada geese (Branta canadensis) and blue geese (Chen caerulescens) were caught with alpha-chloralose, an oral hypnotic administered on bait. Wild turkeys (Meleagris gallopavo) were captured with alpha-chloralose, an oral anesthetic.

Uses

Chloralose is used for the control of rodents, particularly mice, and as a bird repellent and a bird narcotic.

Hazard

May cause addiction, highly toxic.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of Cl-.

Metabolic pathway

Chloralose is effectively a chloral generator which, in turn, affords trichloroethanol by metabolism. This is the narcotic agent. Sleep is induced in mice before death and therefore the compound is regarded as a humane mouse killer. It is particularly effective when a quick clearout is required but there is evidence that mice can become tolerant.

Degradation

Chloralose is hydrolysed by acid and base to glucose and chloral (2, trichloroacetaldehyde).