ChemicalBook > CAS DataBase List > 4-Fluoro-1,3-dihydro-2H-indol-2-one

4-Fluoro-1,3-dihydro-2H-indol-2-one

Product Name
4-Fluoro-1,3-dihydro-2H-indol-2-one
CAS No.
138343-94-9
Chemical Name
4-Fluoro-1,3-dihydro-2H-indol-2-one
Synonyms
4-fluoro-1H-indol-2-ol;4-Fluorooxindole;4-FLUOROINDOLIN-2-ONE;4-fluoroindoline-2-one;4-Fluoro-2-oxindole97%;4-Fluoro-2H-indol-2-one;1H-indol-4-yl hypofluorite;4-Fluoro-1,3-dihydro-indol-2-one;4-Fluoro-2,3-dihydro-1H-indol-2-one;4-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE
CBNumber
CB9711657
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
138343-94-9.mol
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4-Fluoro-1,3-dihydro-2H-indol-2-one Property

Boiling point:
297.2±40.0 °C(Predicted)
Density 
1.311±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
13.08±0.20(Predicted)
form 
powder
color 
Faint creamy orange
InChI
InChI=1S/C8H6FNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
InChIKey
WKDSLMNPSVQOES-UHFFFAOYSA-N
SMILES
N1C2=C(C(F)=CC=C2)CC1=O
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Safety

Hazard Codes 
Xi
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F595008
Product name
4-Fluorooxindole
Packaging
250mg
Price
$75
Updated
2021/12/16
TRC
Product number
F595008
Product name
4-Fluorooxindole
Packaging
1g
Price
$175
Updated
2021/12/16
Apolloscientific
Product number
PC8677
Product name
4-Fluoro-2-oxindole
Purity
97%
Packaging
5g
Price
$222
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-3-22
Product name
4-Fluoro-2-oxindole
Purity
97%
Packaging
5G
Price
$356
Updated
2021/12/16
Apolloscientific
Product number
PC8677
Product name
4-Fluoro-2-oxindole
Purity
97%
Packaging
10g
Price
$370
Updated
2021/12/16
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4-Fluoro-1,3-dihydro-2H-indol-2-one Chemical Properties,Usage,Production

Synthesis

136916-19-3

138343-94-9

General procedure for the synthesis of 4-fluoroindol-2-one from 2-fluoro-6-nitrophenylacetic acid: (2-fluoro-6-nitrophenyl)acetic acid (3.3 g, 16.6 mmol) was dissolved in acetic acid (20 mL) and the hydrogenation reaction was carried out for 24 hours using a 10% palladium-carbon catalyst (0.5 g) under 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was filtered through Celite to remove the catalyst. The filter cake was washed with methanol and the organic phases were combined and concentrated by evaporation. Subsequently, the concentrate was dissolved in ethanol (100 mL), p-toluenesulfonic acid (50 mg) was added and heated to reflux for 1 hour. At the end of the reaction, the mixture was poured into water and extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate and concentrated by evaporation. Finally, the resulting solid was ground with hexane/ethyl acetate (95/5) mixed solvent to afford 4-fluoro-1,3-dihydro-2H-indol-2-one 1.7 g in 67% yield.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1861 - 1873
[2] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 10

4-Fluoro-1,3-dihydro-2H-indol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Fluoro-1,3-dihydro-2H-indol-2-one manufacturers

Chemwill Asia Co.,Ltd.
Product
4-Fluorooxindole; 4-fluoroindolin-2-one; 4-Fluoro-1,3-dihydro-2H-indol-2-one in stock Factory 138343-94-9
Price
US $1.00/kg
Min. Order
1kg
Purity
High quality purified Factory in China
Supply Ability
Top 3 production capacity Factory
Release date
2019-04-03

138343-94-9, 4-Fluoro-1,3-dihydro-2H-indol-2-oneRelated Search:

4-Fluoro-1,3-dihydro-2H-indol-2-one 4-Fluoroindoline-2,3-dione 4,5-DIFLUOROOXINDOLE 4,6-DIFLUOROOXINDOLE 5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE 4,6-DIFLUOROINDOLINE-2,3-DIONE 4-Fluoro-7-Methyl Isatin 6-Chloro-5-fluoro-1,3-dihydro-2H-indol-2-one 5-Trifluoromethyl-2-oxindole 7-Fluorooxindole 7-TRIFLUOROMETHYLOXINDOLE 4-Chloro-5-fluoro-1,3-dihydro-2H-indol-2-one 6-TRIFLUOROMETHYLOXINDOLE Oxindole 4,5,6-TRIFLUOROINDOLINE-2,3-DIONE 6-BROMO-4-FLUORO-2-OXYINDOLE 4,7-DIFLUORO-2-OXYINDOLE 4,7-DIFLUOROISATIN

  • 4-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE
  • 4-FLUOROINDOLIN-2-ONE
  • 4-fluoroindoline-2-one
  • 4-Fluorooxindole
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  • 4-Fluoro-2-oxindole97%
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  • 1H-indol-4-yl hypofluorite
  • 4-Fluoro-1,3-dihydro-2H-indol-2-one in stock Factory
  • 2H-Indol-2-one, 4-fluoro-1,3-dihydro-
  • 4-Fluoro-1,3-dihydro-indol-2-one
  • 138343-94-9
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  • INDOLE