Betahistine mesylate
- Product Name
- Betahistine mesylate
- CAS No.
- 54856-23-4
- Chemical Name
- Betahistine mesylate
- Synonyms
- TENYL;Melopat;Extovyl;Aequamen;Merislon;NSC44059;NSC 44059;NSC-44059;Meginalisk;Einecs 259-377-7
- CBNumber
- CB9713565
- Molecular Formula
- C8H12N2.2CH4O3S
- Formula Weight
- 328.41
- MOL File
- 54856-23-4.mol
Betahistine mesylate Property
- Melting point:
- 112°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Very soluble in water, freely soluble in ethanol (96 per cent), very slightly soluble in 2-propanol.
- color
- White to Off-White
- Water Solubility
- almost transparency
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 54856-23-4(CAS DataBase Reference)
Safety
- RTECS
- UT2970200
- HS Code
- 2933.39.9200
- Toxicity
- LD50 orl-rat: 3030 mg/kg NIIRDN 6,750,82
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- B0990000
- Product name
- Betahistine mesilate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- b0990000
- Price
- $61.2
- Updated
- 2024/03/01
- Product number
- B1424
- Product name
- Betahistine Methanesulfonate
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $78
- Updated
- 2024/03/01
- Product number
- FB170146
- Product name
- Betahistine mesylate
- Packaging
- 50g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- H520
- Product name
- Betahistinedimesilate
- Packaging
- 10g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 37640
- Product name
- Betahistinemethanesulfonate,99%(Assaybytitration,HPLC)
- Purity
- 99%(Assaybytitration,HPLC)
- Packaging
- 25G
- Price
- $126.56
- Updated
- 2021/12/16
Betahistine mesylate Chemical Properties,Usage,Production
Chemical Properties
White or almost white, crystalline powder, very hygroscopic.
Uses
Vasodilatator;H1 agonist
Betahistine mesylate is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine mesylate is used for the study of rheumatoid arthritis (RA).
Definition
Betahistine mesylate is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.
Indications
Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.
Safety Profile
Poison by subcutaneous route.Moderately toxic by ingestion and other routes. Whenheated to decomposition it emits toxic fumes of NOx andSOx.
in vitro
In Vitro: Betahistine mesylate (0-10 μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9 μM and 3.3 μM, respectively. Lead to Ki values of 1.4 μM and 2.5 μM, respectively.
Betahistine mesylate (0-10 μM) has a regulating function on cAMP formation in CHO (rH3(445)R), CHO (rH3(413)R), and CHO (hH3(445)R) cells. At low concentrations, Betahistine mesylate behaves an apparent inverse agonist, and progressively enhances cAMP formation with EC50 values of 0.1 nM, 0.05 nM and 0.3 nM, respectively. In contrast, at concentrations higher than 10 nM, Betahistine mesylate inhibits cAMP formation with an EC50 value of 0.1 μM in CHO (rH3(445)R) and full agonist activity.
Mode of action
Betahistine is indicated for the treatment of Meniere's disease and other audiovestibular disorders like vertigo and tinnitus. Betahistine is an analogue of histamine and an H1-receptor agonist. Stimulating the H1- receptors in the inner ear causes a vasodilatory effect and increased permeability in the blood vessels, resulting in reduced endolymphatic pressure. Betahistine acts by reducing the asymmetrical functioning of sensory vestibular organs and increasing vestibulocochlear blood flow, decreasing symptoms of vertigo, tinnitus, balance disorders, and hearing loss associated with Meniere's disease. Betahistine also acts as a histamine H3- receptor antagonist which causes an increased output of histamine, increase in the direct H1-agonist activity, and inhibition of the activity of vestibular nuclei, helping to restore proper balance and decrease in vertigo symptoms.
Betahistine mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Betahistine mesylate manufacturers
- Product
- Betahistine mesylate 54856-23-4
- Price
- US $35.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-19
- Product
- Betahistine mesylate 54856-23-4
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2023-04-19
- Product
- Betahistine mesylate 54856-23-4
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kg
- Release date
- 2021-10-20