DIETHYLPHOSPHONOACETIC ACID

Product Name: DIETHYLPHOSPHONOACETIC ACID
CAS No.: 3095-95-2
Chemical Name: DIETHYLPHOSPHONOACETIC ACID
Synonyms: 2-(diethoxyphosphoryl)acetic acid;NSC 272281;Diethyl sulfonic acid;Venadaparib Impurity 39;acetyl diethyl phosphate;Diethylphosphoacetic acid;2-diethoxyphosphorylacetate;(diethoxyphosphoryl)acetate;DIETHYLPHOSPHONOACETIC ACID;DIETHYLPHOSPHONOETHANOIC ACID
CBNumber: CB9724914
Molecular Formula: C6H13O5P
Formula Weight: 196.14
MOL File: 3095-95-2.mol

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DIETHYLPHOSPHONOACETIC ACID Property

Boiling point:: 150 °C/0.05 mmHg (lit.)
Density: 1.220 g/mL at 25 °C (lit.)
refractive index: n20/D 1.445(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Viscous Liquid
pka: 3.48±0.10(Predicted)
Specific Gravity: 1.220
color: Clear colorless to yellow
InChI: InChI=1S/C6H13O5P/c1-3-10-12(9,11-4-2)5-6(7)8/h3-5H2,1-2H3,(H,7,8)
InChIKey: DVQMPWOLBFKUMM-UHFFFAOYSA-N
SMILES: C(O)(=O)CP(OCC)(OCC)=O

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 268127
Product name: Diethylphosphonoacetic acid
Purity: 95%
Packaging: 5ml
Price: $18.76
Updated: 2024/03/01

Sigma-Aldrich

Product number: 268127
Product name: Diethylphosphonoacetic acid
Purity: 95%
Packaging: 25ml
Price: $143
Updated: 2024/03/01

TRC

Product number: D444745
Product name: Diethylphosphonoacetic acid
Packaging: 25g
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ING0004122
Product name: DIETHYLPHOSPHONOACETIC ACID
Purity: 95.00%
Packaging: 5ML
Price: $775.24
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ING0004122
Product name: DIETHYLPHOSPHONOACETIC ACID
Purity: 95.00%
Packaging: 25ML
Price: $1112.15
Updated: 2021/12/16

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DIETHYLPHOSPHONOACETIC ACID Chemical Properties,Usage,Production

Description

Diethylphosphonoacetic Acid (DPA) is a Horner-Wadsworth-Emmons (HWE) reagent. The mixed anhydride of trifluoroacetic acid—diethylphosphonoacetic acid Treat a 21-hydroxy-20-keto steroid leads directly to cardenolides by an intramolecular Horner-Emmons reaction. It could also used as a dummy template to prepare a molecularly imprinted polymer for use as an artificial receptor for organophosphorus pesticides (OPPs)[1-3].

Chemical Properties

clear colorless to yellow viscous liquid

Uses

Diethylphosphonoacetic Acid is a reagent that is used for enantioselective preparation of α-phosphoryl-α,β-unsatd.-δ-aryl-δ-lactones from nonracemic β-hydroxyaldehydes and their conversion to α-methylene-δ-aryl-δ-lactones.

Uses

Acts as a nucleophile for nucleophilic addition reactions for synthesis of allene epoxides

Reactant for:

Stereoselectivity studies of the Staudinger reaction
Enantioselective formation of diols via epoxidation and hydration reactions
Horner-Wadsworth-Emmons reactions
Remote chelation controlled Ireland-Claisen rearrangement
Ugi-Dieckmann reactions for synthesis of tetramic acid derivatives

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 4534, 1980 DOI: 10.1021/ja00533a047

References

[1] S. Donovan, J. Mcmurry, M. Avery. “Synthesis of digitoxigenin by remote functionalization.” Tetrahedron Letters 20 1 (1979): 3287–3290.
[2] A. M. Boldi, Hisham O. Eissa, Charles R. Johnson. “Solid-phase library synthesis of triazolopyridazines via [4+2] cycloadditions.” Tetrahedron Letters 40 1 (1999): 619–622.
[3] Lu Zhang. “Preparation and Characterization of Broad-Spectrum Artificial Antibody for OPPs Based on Dummy Template Imprinting Technique.” International Journal of Polymer Analysis and Characterization 117 1 (2014): 510–521.

DIETHYLPHOSPHONOACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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DIETHYLPHOSPHONOACETIC ACID Suppliers

Belgium 2 Canada 1 China 184 France 3 Germany 4 India 4 Italy 1 Japan 4 Poland 1 Switzerland 2 United Kingdom 7 United States 19 Global 232

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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INTATRADE GmbH

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future industrial shanghai co., ltd

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View Lastest Price from DIETHYLPHOSPHONOACETIC ACID manufacturers

Nanjing Fred Technology Co., Ltd

Product: 2-(Diethoxyphosphinyl)acetic acid 3095-95-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

Weijer International Trade (Hebei) Co., Ltd

Product: Diethylphosphonoacetic acid 3095-95-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 3000T
Release date: 2023-03-23

Henan Aochuang Chemical Co.,Ltd.

Product: Diethylphosphonoacetic acid 3095-95-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

3095-95-2, DIETHYLPHOSPHONOACETIC ACIDRelated Search:

Triethyl 2-chloro-2-phosphonoacetate BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE DIETHYLPHOSPHONOACETIC ACID ETHYL ESTER TRIETHYL 2-PHOSPHONOBUTYRATE TRIETHYL 2-PHOSPHONOPROPIONATE TRIETHYL 2-PHOSPHONOPENTANOATE DIETHYLPHOSPHONOACETIC ACID METHYL ESTER TRIMETHYLSILYL DIETHYLPHOSPHONOACETATE DIETHYLPHOSPHONOACETIC ACID Triethyl 2-fluoro-2-phosphonoacetate Triethyl phosphonobromoacetate DIETHYLPHOSPHONOACETIC ACID TERT-BUTYL ESTER DIETHYLPHOSPHONOACETIC ACID ETHYL ESTER PHOSPHONOACETIC ACID TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE TRIETHYL PHOSPHONOACETATE-13C2 TRIETHYL 2,2-DICHLORO-2-PHOSPHONOACETATE 2-ETHOXY-TRIETHYLPHOSPHONOACETATE

DIETHYLPHOSPHONOACETIC ACID

DIETHYLPHOSPHONOETHANOIC ACID

(DIETHOXYPHOSPHINOYL)ACETIC ACID

DIETHYLCARBOXYMETHYLPHOSPHONATE

Diethylcarboxymethylphosphonate, 98 %

2-diethoxyphosphorylacetate

Diethylphosphoacetic acid

(diethoxyphosphoryl)acetate

(Diethoxyphosphinyl)acetic acid

2-(Diethoxyphosphinyl)acetic acid

Diethylphosphonoacetic acid,98%

(Diethoxyphosphoryl)acetic acid, Diethylphosphonoacetic acid

Diethyl (hydroxycarbonylmethyl)phosphonate

acetyl diethyl phosphate

Diethylphosphonoacetic acid, 98% 25GR

2-(diethoxyphosphoryl)acetic acid

Diethoxyphosphorylacetic acid

Diethyl carboxymethanephosphonate

Phosphono-acetic acid P,P-diethyl ester

Acetic acid,2-(diethoxyphosphinyl)-

Diethylphosphonoacetic acid 95%

NSC 272281

DIETHYLPHOSPHONOACETIC ACID(3095-95-2)

2-diethoxyphosphorylaceticaci

Diethyl sulfonic acid

Venadaparib Impurity 39

3095-95-2

3095-95-5

C6H13O5P

C2H5O2POCH2CO2H

Synthetic Reagents

Olefination

Horner-Wadsworth-Emmons Reagents

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination

C-C Bond Formation