Triethyl 2-fluoro-2-phosphonoacetate

Product Name: Triethyl 2-fluoro-2-phosphonoacetate
CAS No.: 2356-16-3
Chemical Name: Triethyl 2-fluoro-2-phosphonoacetate
Synonyms: ethyl 2-(diethoxyphosphoryl)-2-fluoroacetate;czj;uoro-2-phosphonoacetate;Triethyl-2-Fluoro-2-Phosphono;triethylphosphonofluoroacetate;Triethyl2-Fluoro-2-phosphoacetate;RIETHYL2-FLUORO-2-PHOSPHONOACETATE;Triethyl-2-fluoro-phosphonoacetate;Triethyl α-fluoro(phosphono)acetate;Ethyl diethylphosphonofluoroacetate
CBNumber: CB9119497
Molecular Formula: C8H16FO5P
Formula Weight: 242.18
MOL File: 2356-16-3.mol

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Triethyl 2-fluoro-2-phosphonoacetate Property

Boiling point:: 75 °C0.01 mm Hg(lit.)
Density: 1.194 g/mL at 25 °C(lit.)
refractive index: n20/D 1.425(lit.)
Flash point:: 165 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: clear liquid
color: Colorless to Almost colorless
Specific Gravity: 1.194
BRN: 1912161
InChI: InChI=1S/C8H16FO5P/c1-4-12-8(10)7(9)15(11,13-5-2)14-6-3/h7H,4-6H2,1-3H3
InChIKey: FVPISMANESAJQZ-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(P(OCC)(OCC)=O)F
CAS DataBase Reference: 2356-16-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 10-21
Hazard Note: Irritant
HazardClass: IRRITANT, FLAMMABLE
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0340
Product name: Triethyl 2-Fluoro-2-phosphonoacetate
Purity: >95.0%(GC)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: F0340
Product name: Triethyl 2-Fluoro-2-phosphonoacetate
Purity: >95.0%(GC)
Packaging: 5g
Price: $78
Updated: 2025/07/31

TRC

Product number: T798115
Product name: Triethyl 2-fluoro-2-phosphonoacetate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6177-3-02
Product name: Triethyl 2-fluoro-2-phosphonoacetate
Purity: 96%
Packaging: 5G
Price: $30
Updated: 2021/12/16

Matrix Scientific

Product number: 002202
Product name: 2-Fluoro-2-phosphonoacetic acid triethyl ester
Purity: 95%
Packaging: 5g
Price: $48
Updated: 2021/12/16

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Triethyl 2-fluoro-2-phosphonoacetate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

Reactant for:

Diels-Alder reactions
Biosynthesis of terpene
Stereoselective synthesis of unsaturated esters, fluorides and nitriles from the reactions of aldehydes and ketones using Wadsworth-Emmons phosphonates
Synthesis of quinolones
Horner-Wadsworth-Emmons asymmetric hydration
Addition reactions and the subsequent application to click chemistry
Asymmetric intermolecular Stetter reactions

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 4730, 1995 DOI: 10.1021/jo00120a014

reaction suitability

reaction type: C-C Bond Formation

Synthesis

401-55-8

122-52-1

2356-16-3

Ethyl 2-bromo-2-fluoroacetate (5.0 g, 27 mmol) was mixed with triethyl phosphite (13 mL) and the reaction was heated at 130°C for 23 hours. After completion of the reaction, the resulting mixture was distilled under reduced pressure (1.4 mbar, 75-110°C) to afford triethyl 2-fluoro-2-phosphonoacetate, the product being a pale yellow oil (6.0 g, 92% yield).

References

[1] Phosphorus, Sulfur and Silicon and Related Elements, 2000, vol. 160, p. 195 - 205
[2] Patent: WO2017/100668, 2017, A1. Location in patent: Page/Page column 162
[3] Patent: WO2018/103058, 2018, A1. Location in patent: Page/Page column 161; 165-166; 339
[4] Journal of the American Chemical Society, 2007, vol. 129, # 15, p. 4536 - 4537
[5] Heterocycles, 2004, vol. 63, # 3, p. 699 - 706

Triethyl 2-fluoro-2-phosphonoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Triethyl 2-fluoro-2-phosphonoacetate Suppliers

Americas 1 Belgium 2 Canada 2 China 157 Europe 1 France 4 Germany 4 India 7 Japan 8 Switzerland 2 United Kingdom 12 United States 41 Global 241

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View Lastest Price from Triethyl 2-fluoro-2-phosphonoacetate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Triethyl 2-fluoro-2-phosphonoacetate 2356-16-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2025-04-01

Career Henan Chemical Co

Product: Triethyl 2-fluoro-2-phosphonoacetate 2356-16-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 752
Release date: 2019-09-01

2356-16-3, Triethyl 2-fluoro-2-phosphonoacetateRelated Search:

Ethyl chloroacetate Ethyl bromodifluoroacetate Ethyl acetate Ethyl trifluoroacetate Triethyl phosphate Triethyl phosphite Ethyl phenylacetate Triethyl phosphonoacetate Ethyl bromoacetate Triethyl 2-chloro-2-phosphonoacetate Ethyl dimethylphosphonoacetate Ethyl fluoroacetate DIETHYLPHOSPHONOACETIC ACID Trimethyl phosphonoacetate PHOSPHONOACETIC ACID Methyl diethylphosphonoacetate TRIETHYL PHOSPHONOACETATE ARSENIC ACID TRIETHYL ESTER

2-FLUORO-2-PHOSPHONOACETIC ACID TRIETHYL ESTER 95+%

RIETHYL2-FLUORO-2-PHOSPHONOACETATE

2-Fluoro-2-(diethoxyphosphinyl)acetic acid ethyl ester

Fluoro(diethoxyphosphinyl)acetic acid ethyl ester

Diethyl [(ethoxycarbonyl)fluoromethyl]phosphonate 96%

Ethyl (diethoxyphosphonyl)(fluoro)acetate, 2-Fluoro-2-phosphonoacetic acid triethyl ester

(Diethoxyphosphinyl)fluoroacetic Acid Ethyl Ester Ethyl (Diethoxyphosphinyl)fluoroacetate 2-Fluoro-2-phosphonoacetic Acid Triethyl Ester

ethyl 2-(diethoxyphosphoryl)-2-fluoroacetate

Triethyl α-fluoro(phosphono)acetate

Ethyl (diethoxyphosphoryl)(fluoro)acetate, Ethyl (diethylphosphono)(fluoro)acetate

2-Fluoro-2-phosphonoacetic acid triethyl ester 96%

2-Fluoro-2-phosphonoaceticacidtriethylester97%

Triethyl-2-fluoro-phosphonoacetate

2-Phosphono-2-fluoroacetic acid triethyl ester

ETHYL (DIETHOXYPHOSPHORYL)(FLUORO)ACETATE

2-diethoxyphosphoryl-2-fluorobutanoate

Diethyl [(ethoxycarbonyl)fluoromethyl]phosphonate

Ethyl diethylphosphonofluoroacetate

Triethyl 2-fluoro-2-phosphonoacetate 96%

(R,S)-(Diethoxy-phosphoryl)-fluoro-aceticacidethylester

triethylphosphonofluoroacetate

TRIETHYL 2-FLUORO-2-PHOSPHONOACETATE

2-FLUORO-2-PHOSPHONOACETIC ACID TRIETHYL ESTER

ETHYL (DIETHOXYPHOSPHINYL)FLUOROACETATE

(DIETHOXYPHOSPHINYL)FLUOROACETIC ACID ETHYL ESTER

TRIETHYL 2-FLUORO-2-PHOSPHONOACETATE, 96 %

2-Fluoro-2-phosphonoaceticacidtriethylester(FluorinatedHornerreagent)

Triethyl2-Fluoro-2-phosphoacetate

Triethyl-2-Fluoro-2-Phosphono

Triethyl2-Fluoro-2-phosphonoacetate&gt

uoro-2-phosphonoacetate

czj

Acetic acid, 2-(diethoxyphosphinyl)-2-fluoro-, ethyl ester

2-(diethoxyphosphinyl)-2-fluoro-Acetic acid ethyl ester

ethyl 2-(diethoxyphosphoryl)-2-fluoroacetate - [E72890]

2356-16-3

236-16-3

C2H5O2POCHFCO2C2H5

C2H5O2POCHFCO2

C8H16FO5P

Horner-Wadsworth-Emmons Reagents

Synthetic Reagents

Olefination

C-C Bond Formation

Fluorinated Building Blocks

Wittig & Horner-Emmons Reaction

Horner-Emmons Reaction

Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds

Phosphorus compounds

Fluorinated Building Blocks

Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds

Horner-Emmons Reaction

Synthetic Organic Chemistry

Wittig & Horner-Emmons Reaction

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination