RO 106-9920

Product Name: RO 106-9920
CAS No.: 62645-28-7
Chemical Name: RO 106-9920
Synonyms: RO 106-9920;Ro 106 9920,Ro 1069920;Ro 106-9920 DISCONTINUED;TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE;6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE;Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-
CBNumber: CB9728932
Molecular Formula: C10H7N5OS
Formula Weight: 245.26
MOL File: 62645-28-7.mol

More

Less

RO 106-9920 Property

storage temp.: Store at +4°C
solubility: Soluble to 5 mM in ethanol and to 100 mM in DMSO
form: White solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 557550
Product name: Ro 106-9920
Packaging: 1mg
Price: $159
Updated: 2024/03/01

Cayman Chemical

Product number: 15373
Product name: Ro 106-9920
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 15373
Product name: Ro 106-9920
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 15373
Product name: Ro 106-9920
Purity: ≥95%
Packaging: 10mg
Price: $158
Updated: 2024/03/01

Usbiological

Product number: 256474
Product name: Ro 106-9920
Packaging: 10mg
Price: $409
Updated: 2021/12/16

More

Less

RO 106-9920 Chemical Properties,Usage,Production

Uses

Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Definition

ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide.

Biological Activity

Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

RO 106-9920 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

RO 106-9920 Suppliers

China 47 Germany 2 India 1 Switzerland 1 United Kingdom 1 United States 8 Global 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52925
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

EMD Biosciences, Inc.

Tel: --
Fax: --
Email: technical@calbiochem.com
Country: United States
ProdList: 6529
Advantage: 66

62645-28-7, RO 106-9920Related Search:

RO 106-9920, CONTROL 5-METHYL-1-AMINOTETRAZOLE RO 106-9920

RO 106-9920

TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE

6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE

Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-

Ro 106-9920 DISCONTINUED

Ro 106 9920,Ro 1069920

62645-28-7

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Gene Regulation and Expression

Gene Regulation

Cytokine signaling

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds