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PROMETHAZINE

Product Name
PROMETHAZINE
CAS No.
60-87-7
Chemical Name
PROMETHAZINE
Synonyms
Promethazin;Isopromethazine;Aprobit;Dimapp;Fargan;Procit;Prorex;WY 509;3277 RP;A-91033
CBNumber
CB9744071
Molecular Formula
C17H20N2S
Formula Weight
284.42
MOL File
60-87-7.mol
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PROMETHAZINE Property

Melting point:
60℃
Boiling point:
bp3 190-192°
Density 
1.131
refractive index 
1.6000 (estimate)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
pKa 9.1(H2O,t undefined) (Uncertain)
color 
Pale Beige to Pale Brown
Water Solubility 
383.9ug/L(22.5 ºC)
EPA Substance Registry System
Promethazine (60-87-7)
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Safety

Hazardous Substances Data
60-87-7(Hazardous Substances Data)
Toxicity
LD50 oral in rabbit: 580mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PH011183
Product name
N,N-dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine
Purity
AldrichCPR
Packaging
500mg
Price
$172
Updated
2023/06/20
American Custom Chemicals Corporation
Product number
CHM0031920
Product name
PROMETHAZINE
Purity
95.00%
Packaging
500MG
Price
$727.65
Updated
2021/12/16
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PROMETHAZINE Chemical Properties,Usage,Production

Description

As a derivative of phenothiazine, promethazine is structurally and pharmacologically similar to chlorpromazine. It exhibits strong antihistamine activity as well as expressed action on the CNS. It potentiates action of sedative and analgesic drugs.

Uses

Promethazine is used in preparation of antibodies having inhibitory activities to IL-36R signaling triggered by agonistic ligands and application to prevention and therapies of cancers and autoimmune diseases.

Uses

Promethazine is used for treating allergic illnesses such as hives, serum disease, hay fever, dermatosis, and also for rheumatism with expressed allergic components, for allergic complications caused by antibiotics and other medicinal drugs, and for enhancing action of analgesics and local anesthetics. Synonyms of this drug are allergen, phenergan, pipolphen, prothazine, and others.

Uses

Anti-emetic; antihistaminic.

Definition

ChEBI: A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

brand name

Phenergan (Wyeth).

World Health Organization (WHO)

Introduced in 1946, promethazine, a phenothiazine derivative has a variety of pharmacological properties. At present it is mainly used as an antihistamine and anti-motion-sickness drug. Promethazine is listed in the WHO Model List of Essential Drugs.

General Description

Crystals. Melting point 60°C. Used as an antihistaminic.

Air & Water Reactions

Turns blue on prolonged exposure to air and moisture.

Reactivity Profile

PROMETHAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable or toxic gases may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of PROMETHAZINE include leucopenia; agranulocytosis; confusion; convulsions; stupor; and it potentiates the action of central nervous system depressants.

Fire Hazard

Flash point data for PROMETHAZINE are not available, however PROMETHAZINE is probably combustible.

Clinical Use

Promethazine, an early agent in the series, has many useful pharmacological affects other than being an antihistamine. It has significant antiemetic and anticholinergic properties. It also has sedative-hypnotic properties and has been used to potentiate the effects of analgesic drugs. Subsequent analogues, such as trimeprazine and methdilazine, are used as antipruritic agents in the treatment of urticaria.

Safety Profile

Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effectsHuman mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx

Synthesis

Promethazine, 10-(2-dimethylaminopropyl)phenothiazine (16.1.18), is synthesized by alkylating phenothiazine with 1-dimethylamino-2-propylchloride.

PROMETHAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PROMETHAZINE manufacturers

Sinoway Industrial co., ltd.
Product
Promethazine 60-87-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20TONS
Release date
2024-11-25
Hebei Longbang Technology Co., Ltd
Product
Promethazine 60-87-7
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-06-07
Hebei Dangtong Import and export Co LTD
Product
PROMETHAZINE 60-87-7
Price
US $16417.00/kg
Min. Order
10kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17

60-87-7, PROMETHAZINERelated Search:


  • Promethazine (base and/or unspecified salts)
  • 10-(2-DIMETHYLAMINOPROPYL)-PHENOTHIAZIN
  • 10-[2-(Dimethylamino)propyl]-10H-phenothiazine
  • dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)amine
  • N,N-dimethyl-1-phenothiazin-10-yl-propan-2-amine
  • N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
  • N,N-diMethyl-1-(10H-phenothiazin-10-yl)propan-2-aMine
  • 10H-Phenothiazine-10-ethanaMine,N,N,a-triMethyl-
  • N,N,a-Trimethyl-10H-phenothiazine-10-ethanamine
  • NSC 30321
  • 10H-Phenothiazine-10-ethanamine, N,N,a-trimethyl- (9CI)
  • Phenothiazine, 10-[2-(dimethylamino)propyl]- (8CI)
  • PROMETHAZINE
  • Promethaine
  • (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
  • (Dimethylamino-2-propyl-10-phenothiazine hydrochloride
  • 10-(2-(Dimethylamino)-2-methylethyl)phenothiazine
  • 10-[2-(Dimethylamino)propyl]phenothiazine
  • 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-
  • 3277 RP
  • 3389 R.P.
  • 4182 R.P.
  • A-91033
  • Aprobit
  • Avomine
  • Dimapp
  • Dimethylamino-isopropyl-phenthiazin
  • Diphergan
  • Diprazine
  • Diprozin
  • Fargan
  • Fenazil
  • Fenetazina
  • Hiberna
  • Histargan
  • Iergigan
  • Isophenergan
  • Isopromethazine
  • Lercigan
  • Lergigan
  • Lilly 01516
  • Lilly 1516
  • N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine
  • N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine
  • NCI-C60673
  • N-Dimethylamino-2-methylethyl thiodiphenylamine
  • Phargan
  • Phenargan
  • Phenothiazine, 10-[2-(dimethylamino)propyl]-
  • Phensedyl
  • Pilpophen
  • Pipolphen
  • Proazaimine
  • Proazamine
  • Procit
  • Promazinamide
  • Prometasin
  • Prometazin