PROMETHAZINE
- Product Name
- PROMETHAZINE
- CAS No.
- 60-87-7
- Chemical Name
- PROMETHAZINE
- Synonyms
- Promethazin;Isopromethazine;Aprobit;Dimapp;Fargan;Procit;Prorex;WY 509;3277 RP;A-91033
- CBNumber
- CB9744071
- Molecular Formula
- C17H20N2S
- Formula Weight
- 284.42
- MOL File
- 60-87-7.mol
PROMETHAZINE Property
- Melting point:
- 60℃
- Boiling point:
- bp3 190-192°
- Density
- 1.131
- refractive index
- 1.6000 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- pKa 9.1(H2O,t undefined) (Uncertain)
- color
- Pale Beige to Pale Brown
- Water Solubility
- 383.9ug/L(22.5 ºC)
- EPA Substance Registry System
- Promethazine (60-87-7)
Safety
- Hazardous Substances Data
- 60-87-7(Hazardous Substances Data)
- Toxicity
- LD50 oral in rabbit: 580mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PH011183
- Product name
- N,N-dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine
- Purity
- AldrichCPR
- Packaging
- 500mg
- Price
- $172
- Updated
- 2023/06/20
- Product number
- CHM0031920
- Product name
- PROMETHAZINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $727.65
- Updated
- 2021/12/16
PROMETHAZINE Chemical Properties,Usage,Production
Description
As a derivative of phenothiazine, promethazine is structurally and pharmacologically similar to chlorpromazine. It exhibits strong antihistamine activity as well as expressed action on the CNS. It potentiates action of sedative and analgesic drugs.
Uses
Promethazine is used in preparation of antibodies having inhibitory activities to IL-36R signaling triggered by agonistic ligands and application to prevention and therapies of cancers and autoimmune diseases.
Uses
Promethazine is used for treating allergic illnesses such as hives, serum disease, hay fever, dermatosis, and also for rheumatism with expressed allergic components, for allergic complications caused by antibiotics and other medicinal drugs, and for enhancing action of analgesics and local anesthetics. Synonyms of this drug are allergen, phenergan, pipolphen, prothazine, and others.
Uses
Anti-emetic; antihistaminic.
Definition
ChEBI: A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
brand name
Phenergan (Wyeth).
World Health Organization (WHO)
Introduced in 1946, promethazine, a phenothiazine derivative has a variety of pharmacological properties. At present it is mainly used as an antihistamine and anti-motion-sickness drug. Promethazine is listed in the WHO Model List of Essential Drugs.
General Description
Crystals. Melting point 60°C. Used as an antihistaminic.
Air & Water Reactions
Turns blue on prolonged exposure to air and moisture.
Reactivity Profile
PROMETHAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable or toxic gases may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: Symptoms of PROMETHAZINE include leucopenia; agranulocytosis; confusion; convulsions; stupor; and it potentiates the action of central nervous system depressants.
Fire Hazard
Flash point data for PROMETHAZINE are not available, however PROMETHAZINE is probably combustible.
Clinical Use
Promethazine, an early agent in the series, has many useful pharmacological affects other than being an antihistamine. It has significant antiemetic and anticholinergic properties. It also has sedative-hypnotic properties and has been used to potentiate the effects of analgesic drugs. Subsequent analogues, such as trimeprazine and methdilazine, are used as antipruritic agents in the treatment of urticaria.
Safety Profile
Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effectsHuman mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx
Synthesis
Promethazine, 10-(2-dimethylaminopropyl)phenothiazine (16.1.18), is synthesized by alkylating phenothiazine with 1-dimethylamino-2-propylchloride.
PROMETHAZINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from PROMETHAZINE manufacturers
- Product
- PROMETHAZINE 60-87-7
- Price
- US $16417.00/kg
- Min. Order
- 10kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-17
- Product
- Promethazine 60-87-7
- Price
- US $9.00-80.00/g
- Min. Order
- 10g
- Purity
- min99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-27
- Product
- PROMETHAZINE 60-87-7
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08