AC-D-ALA-OH

Product Name: AC-D-ALA-OH
CAS No.: 19436-52-3
Chemical Name: AC-D-ALA-OH
Synonyms: Ac-D-Ala;NSC 203819;AC-D-ALA-OH;AC-D-ALANINE;N-Ac-D-Ala-OH;N-ACETYL-D-ALA;ACETYL-D-ALANINE;N-ACETYL-D-ALANINE;(R)-N-Acetylalanine;D-Alanine, N-acetyl-
CBNumber: CB9744334
Molecular Formula: C5H9NO3
Formula Weight: 131.13
MOL File: 19436-52-3.mol

More

Less

AC-D-ALA-OH Property

Melting point:: 125 °C
Boiling point:: 369.7±25.0 °C(Predicted)
Density: 1.170
storage temp.: -20°C
solubility: Soluble in water or 1% acetic acid
pka: 3.69±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Slightly soluble in water.
InChIKey: KTHDTJVBEPMMGL-VKHMYHEASA-N
LogP: -1.638 (est)

More

Less

Safety

WGK Germany: 3
HS Code: 2922498590

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A4375
Product name: N-Acetyl-D-alanine
Packaging: 1g
Price: $128.8
Updated: 2025/07/31

TCI Chemical

Product number: A3481
Product name: Ac-D-Ala-OH
Packaging: 5G
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: A3481
Product name: Ac-D-Ala-OH
Packaging: 25G
Price: $182
Updated: 2025/07/31

Chem-Impex

Product number: 02605
Product name: Acetyl-D-alanine
Purity: ≥ 98% (Assay)
Packaging: 1G
Price: $15
Updated: 2021/12/16

Chem-Impex

Product number: 02605
Product name: Acetyl-D-alanine,98%(Assay)
Purity: 98%(Assay)
Packaging: 5G
Price: $44.8
Updated: 2021/12/16

More

Less

AC-D-ALA-OH Chemical Properties,Usage,Production

Chemical Properties

White crystal powder

Uses

N-Acetyl-D-alanine may be used with other D-aminoacylated amino acids as a substrate for the identification, differentiation and characterization of D-aminoacylase(s)/amidohydrolase(s). N-acetyl-D-alanine may be used to study aglycon pocket specific binding on vancomycin.

Biochem/physiol Actions

N-Acetyl-D-alanine may be used with other D-aminoacylated amino acids as a substrate for the identification, differentiation and characterization of D-aminoacylase(s)/amidohydrolase(s). N-acetyl-D-alanine may be used to study aglycon pocket specific binding on vancomycin.

Synthesis

5429-56-1

19436-52-3

The general procedure for the synthesis of N-acetyl-D-alanine from 2-acetamidoacrylic acid is as follows: the substrate (Eq. 3), enantiomeric excess (ee), and absolute stereoconfigurations of the chiral products (Eq. 2) prepared by asymmetric hydrogenation using a chiral catalyst precursor are listed in Table 3. The catalyst precursor was (S)-(+)-(2-{[(di-tert-butyl)-[phosphinylidene]-methyl]-methyl-phosphinyl}-2-methyl-propyl)-(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate (Eq. 23). For each entry in Table 3, the catalyst precursor (0.01 mmol) was dissolved in degassed methanol (1 mL) in a Griffin-Worden pressure vessel equipped with the accessories required for connection to a hydrogen cylinder. The substrate (1 mmol) was first dissolved in methanol (4 mL) and then delivered via syringe into the catalyst-methanol solution. The vessel was sealed and pressurized to 50 psi H2. The time to completion of the reaction was determined by monitoring the cessation of H2 gas absorption. Table 3: Enantioselectivity of chiral compounds prepared by asymmetric hydrogenation of prechiral substrates (Formula 2) (Formula 3) Example R1 R2 R3 R4 X ee Configuration.5 AcNH H H CO2H >99% R 6 AcNH Ph H H CO2H >99% R 7 AcNH H H CO2Me >99% R 8 AcNH Ph H H CO2Me >99% R 9 AcNH - C5H10- CO2Me 99% R For each reaction shown in Table 3, the enantiomeric excess was determined by chiral gas chromatography (GC) or chiral high performance liquid chromatography (HPLC). Table 4 provides details of the ee determination methods. To determine the ee of N-acetylalanine (Example 5) and N-acetylphenylalanine (Example 6), each compound was treated with trimethylsilyl diazomethane, which was converted to its corresponding methyl ester, and analyzed as described in Example 7 or Example 8, respectively. Absolute stereochemical configurations were determined by comparing the sign of the spinodal and literature values: (S)-N-acetylalanine methyl ester [α]20D = -91.7° (c 2, H2O), JP Wolf III C. Neimann, Biochemistry 2: 493 (1963); (S)-N-acetylphenylalanine methyl ester [α]20D = + 16.4° (c 2, MeOH), B.D. Vineyard et al, J. Am. Chem. Soc. 99: 5946 (1997); (S)-N-acetylcyclohexylglycine methyl ester [α]20D = -4.6° (c = 0.13, EtOH), M.J. Burk et al, J. Am. Chem. Soc. 117: 9375 (1995). Table 4: Conditions for Enantiomeric Excess Determination Example Method Column Mobile Phase Flow Rate Column Temperature Concentration Retention Time-R Retention Time-S5 Capillary GC Chrompack Chiral-Daicel - - 120°C - 10.5 min 11.0 min 6 HPLC Chiralcel OJ 10% IPA/hexane 1 mL/min 30°C 2 mg/mL 11.6 min 17.7 min9 Capillary GC Chirasil-L-Val - - 145°C - 11.3 min 12.0 min

References

[1] Advanced Synthesis and Catalysis, 2003, vol. 345, # 1-2, p. 308 - 323
[2] Angewandte Chemie, 1987, vol. 99, # 9, p. 921 - 922
[3] Tetrahedron Letters, 1984, vol. 25, # 43, p. 4965 - 4966
[4] Journal of Organic Chemistry, 1980, vol. 45, # 23, p. 4728 - 4739
[5] Journal of the American Chemical Society, 1981, vol. 103, # 9, p. 2273 - 2280

AC-D-ALA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AC-D-ALA-OH Suppliers

China 136 Denmark 2 Europe 2 Germany 2 India 5 Japan 2 Switzerland 2 United Kingdom 4 United States 19 Global 174

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Penta Manufacturing Company

Tel: --
Fax: --
Email: sales@pentamfg.com
Country: United States
ProdList: 5076
Advantage: 65

Glentham Life Sciences Ltd

Tel: --
Fax: --
Email: info@glentham.com
Country: United States
ProdList: 2026
Advantage: 58

Penta International Corporation

Tel: --
Fax: --
Email: lisaa@pentamfg.com
Country: United States
ProdList: 5042
Advantage: 58

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

Advanced Synthesis Technologies

Tel: --
Fax: --
Email: sales@advancedsynthesis.com
Country: United States
ProdList: 4775
Advantage: 61

EMD Biosciences, Inc.

Tel: --
Fax: --
Email: technical@calbiochem.com
Country: United States
ProdList: 6529
Advantage: 66

INDOFINE Chemical Company, Inc.

Tel: --
Fax: --
Email: chemical@indofinechemical.com
Country: United States
ProdList: 6176
Advantage: 69

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

Advanced ChemTech

Tel: --
Fax: --
Country: United States
ProdList: 1606
Advantage: 69

Research Plus, Inc.

Tel: --
Fax: --
Email: respls@aol.com
Country: United States
ProdList: 3674
Advantage: 51

Focus Synthesis LLC

Tel: --
Fax: --
Email: acd@focussynthesis.com
Country: United States
ProdList: 2487
Advantage: 61

More

Less

View Lastest Price from AC-D-ALA-OH manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: AC-D-ALA-OH 19436-52-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: AC-D-ALA-OH 19436-52-3
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-05

Sichuan Jiaying Lai Technology Co.,LTD

Product: Ac-D-Ala-OH 19436-52-3
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-17

19436-52-3, AC-D-ALA-OHRelated Search:

VALINOMYCIN DIETHYL ACETAMIDOMALONATE-2-13C (R)-(+)-1-(4-Methylphenyl)ethylamine Diethyl acetamidomalonate Ethyl D-(-)-pyroglutamate Penicillin G potassium salt N-ACETYL-D-PHENYLALANINE DIETHYL BENZAMIDOMALONATE 6-Aminopenicillanic acid Ampicillin AC-D-VAL-OH AC-DL-ALA-OH 3-(4-acetylphenyl)-2-aminopropanoic acid hydrochloride AC-DEHYDRO-ALA-OH Ac-L-Ala-OH AC-BETA-ALA-OH H-D-ALA-D-ALA-D-ALA-D-ALA-OH Z-PRO-D-LEU-OH

D-Alanine, N-acetyl-

N-Ac-D-Ala-OH

Acetyl-D-alanine≥ 98% (Assay)

(2R)-2-acetamidopropanoic acid

ACETYL-D-ALANINE

AC-D-ALANINE

AC-D-ALA-OH

N-ALPHA-ACETYL-D-ALANINE

N-ACETYL-D-ALA

N-ACETYL-D-ALANINE

N-acetyl-D-alanine sigma gr

N-Acetyl-D-α-alanine;N-Acetyl-D-alanine

D-Alanine, N-acetyl- (9CI)

N-alpha-Actetyl-D-alanine

(R)-2-ACETAMIDOPROPANOIC ACID

(2R)-2-(Acetylamino)propionic acid

(R)-2-(Acetylamino)propanoic acid

(R)-2-(Acetylamino)propionic acid

N-Acetyl-D-alanine-d4

(R)-N-Acetylalanine

NSC 203819

(2S)-2-(Acetylamino)propanoic acid

N-Acetyl-D-alanine,98%

(2R)-2-acetamidopropanoicaci

AC-D-ALA-OH USP/EP/BP

acetyl-dextro-alanine

Ac-D-Ala

N-Acetyl-<sc>D</sc>-alanine

19436-52-3

Modified Amino Acids

A - H

Amino Acids and Peptides

Biochemicals and Reagents

BioChemical

Amino Acids and Derivatives

Amino Acid Derivatives

A - H

Amino Acids

Modified Amino Acids

Amino Acids

GLYCINESCAFFOLD

Pharmaceutical intermediates

amino