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ChemicalBook > CAS DataBase List > Bromotrimethylsilane

Bromotrimethylsilane

Uses
Product Name
Bromotrimethylsilane
CAS No.
2857-97-8
Chemical Name
Bromotrimethylsilane
Synonyms
TMSBR;TRIMETHYLSILYL BROMIDE;TRIMETHYLBROMOSILANE;TMBS;(CH3)3SiBr;Silane, bromotrimethyl-;CT2928;TMS bromide;BromotrimethyL;Co-Formula CFS-978
CBNumber
CB9749809
Molecular Formula
C3H9BrSi
Formula Weight
153.09
MOL File
2857-97-8.mol
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Bromotrimethylsilane Property

Melting point:
-43 °C
Boiling point:
79 °C(lit.)
Density 
1.16 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.424(lit.)
Flash point:
90 °F
storage temp. 
Store below +30°C.
solubility 
DECOMPOSES
form 
Liquid
Specific Gravity
1.1725
color 
Clear colorless to yellow
Water Solubility 
DECOMPOSES
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN 
1731135
Stability:
Stable. Flammable. Incompatible with strong acids, strong oxidizing agents. May decompose on exposure to water or moist air.
CAS DataBase Reference
2857-97-8(CAS DataBase Reference)
NIST Chemistry Reference
Bromotrimethylsilane(2857-97-8)
EPA Substance Registry System
Silane, bromotrimethyl- (2857-97-8)
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Safety

Hazard Codes 
C
Risk Statements 
10-34-29-14
Safety Statements 
16-26-36/37/39-45-8
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
F 
10-21
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29310095
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14324
Product name
Bromotrimethylsilane
Purity
for synthesis
Packaging
10ml
Price
$88.7
Updated
2024/03/01
Sigma-Aldrich
Product number
194409
Product name
Bromotrimethylsilane
Purity
97%
Packaging
5g
Price
$41.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14324
Product name
Bromotrimethylsilane
Purity
for synthesis
Packaging
100mL
Price
$290
Updated
2024/03/01
Sigma-Aldrich
Product number
194409
Product name
Bromotrimethylsilane
Purity
97%
Packaging
25g
Price
$103
Updated
2024/03/01
TCI Chemical
Product number
B1087
Product name
Bromotrimethylsilane
Purity
>95.0%(GC)
Packaging
5mL
Price
$32
Updated
2024/03/01
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Bromotrimethylsilane Chemical Properties,Usage,Production

Uses

Bromotrimethylsilane can protect or deprotect functional groups selectively, act as silane blocking agent, which is widely used in the syntheses of drugs.

Chemical Properties

Clear yellow liquid

Physical properties

bp 79°C; d 1.188 g cm?3; n20 D 1.4240; fp 32°C.

Uses

Powerful silylating agent

Uses

Adefovir intermediate

Uses

Bromotrimethylsilane is a mild and selective reagent for cleavage of lactones, epoxides, acetals, phosphonate esters and certain ethers; effective reagent for formation of silyl enol ethers; can function as brominating agent.
Amines react with TMS-Br to form isolable adducts, which react readily with ketones to form enamines under mild conditions (eq 15).

Preparation

although many methods are reported, only a few are provided here: chlorotrimethylsilane undergoes halogen exchange with either magnesium bromide in Et2O or sodium bromide in MeCN, which allows in situ reagent formation (eq 1); alternatively, hexamethyldisilane reacts with bromine in benzene solution or neat, to afford only TMS-Br with no byproducts (eq 2).4 TMS-Br may also be generated by reaction of hexamethyldisiloxane and aluminum bromide (eq 3).However, it should be noted that the reactivity of in situ generated reagent appears to depend upon the method of preparation.

General Description

Bromotrimethylsilane is used with Cl3 to catalyze the direct allylation of a variety of alcohols with allyltrimethylsilane.

Purification Methods

Purify it by repeated fractional distillation and store it in sealed ampoules in the dark. [McCusker & Reilly J Am Chem Soc 75 1583 1953.] Also fractionate it through a 15-plate column (0.8 x 32cm packed with 1/16in single turn helices of Pt-Ir wire). [Gilliam et al. J Am Chem Soc 68 1161 1946, Pray et al. J Am Chem Soc 70 433 1948, Beilstein 4 IV 4008.]

Bromotrimethylsilane Preparation Products And Raw materials

Raw materials

PHENYLTRIMETHYLSILANE

Preparation Products

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View Lastest Price from Bromotrimethylsilane manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Bromotrimethylsilane 2857-97-8
Price
US $1000.00-700.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-14
Hubei Changfu Chemical Co., Ltd.
Product
Trimethylbromosilane 2857-97-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
20 tons
Release date
2024-04-28
Hebei Dangtong Import and export Co LTD
Product
Bromotrimethylsilane 2857-97-8
Price
US $20548.00-20000.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
7000ton
Release date
2023-09-15

2857-97-8, BromotrimethylsilaneRelated Search:

(Trifluoromethyl)trimethylsilane N-(Trimethylsilyl)acetamide Chlorotrimethylsilane Iodotrimethylsilane TRIMETHYLSILANE Ethidium bromide Triethylsilane Sodium bromate Clidinium bromide Azidotrimethylsilane Ethoxytrimethylsilane Chloromethyltrimethylsilane Trimethylsilyl cyanide N-(Trimethylsilyl)imidazole (TRIMETHYLSILYL)ACETONITRILE Pyrrole-2-carboxaldehyde Trimethylsulfonium bromide Pivaloyl chloride

  • TMBS, Trimethylbromosilane, Trimethylsilyl bromide
  • Bromotrimethylsilane Trimethylsilylbromide
  • Bromotrimethylsilane,TMBS, Trimethylbromosilane, Trimethylsilyl bromide
  • Bromotrimethylsilane, AcroSeal, 98%
  • BroMotriMethylsilane, Stab. With Copper Powder or Silver Wire
  • Bromotrimethylsilane,98%
  • Trimethylsilyl bromide, TMBS
  • BroMotriMethylsilane, 98% 100GR
  • BroMotriMethylsilane, 98% 25GR
  • BroMotriMethylsilane, 98% 5GR
  • TRIMETHYLSILYL BROMIDE
  • TRIMETHYLBROMOSILANE
  • TMBS
  • TMSBR
  • BROMOTRIMETHYLSILANE
  • TMS bromide
  • Trimethylbromosilane,AdefovirDipivoxil
  • TMSbromide~Trimethylbromosilane~Trimethylsilylbromide
  • BROMOTRIMETHYLSILANE , STABILIZED WITH COPPER POWDER OR SILVER WIRE
  • 3,3'',5,5-TETRAMETHYLBENZIDINESULFATE(TMB-S)
  • Bromotrimethylsilane, 97%, stab. with copper powder or silver wire
  • Trimethylbromosilane, Trimethylsilyl bromide, TMBS
  • BroMotriMethylsilane, 98%, AcroSeal
  • BROMOTRIMETHYLSILANE FOR SYNTHESIS
  • Trimethylbromosilane Trimethylsilyl Bromide
  • Three Methyl broMide silane
  • Trimethylbromosilane≥ 98% (Titration)
  • (CH3)3SiBr
  • bromotrimethyl-silan
  • CT2928
  • Silane, bromotrimethyl-
  • Silane,bromotrimethyl-
  • trimethylbromosilane(tmbs)
  • Trimethylsilicon bromide
  • Bromotrimethylsilane purum, >=97.0% (AT)
  • Bromotrimethylsilane, 97%, stabilized
  • Trimethylsilyl Bromide(TMSB)
  • Co-Formula CFS-978
  • BromotrimethyL
  • Bromotrimethylsilane &gt
  • Bromotrimethylsilane, 98%, AcroSeal&trade
  • BroMotriMethylsilane（In TMS）
  • Bromotrimethylsilane(BTMS)
  • TriMethylbroMosilane CAS
  • 2857-97-8
  • 285-97-8
  • 2587-97-8
  • 857-97-8
  • 2897-97-8
  • C3H9BrSi
  • Silicon Compounds (for Synthesis)
  • Si (Classes of Silicon Compounds)
  • Si-X (F, Br, I) Compounds
  • Protecting and Derivatizing Reagents
  • Protection and Derivatization
  • Synthetic Reagents
  • Silicon-Based
  • Alkyl Silanes