(TRIMETHYLSILYL)ACETONITRILE
- Product Name
- (TRIMETHYLSILYL)ACETONITRILE
- CAS No.
- 18293-53-3
- Chemical Name
- (TRIMETHYLSILYL)ACETONITRILE
- Synonyms
- TMSAN;2-(Trimethy;Einecs 242-169-5;TRIMETHYLSILYACETONITRILE;(TRIMETHYLSILYL)ACETONITRILE;2-Trimethylsilylacetonitrile;(CYANOMETHYL)TRIMETHYLSILANE;trimethylsilanyl-acetonitrile;2-(Trimethylsilyl)acetonitrile;Acetonitrile, (trimethylsilyl)-
- CBNumber
- CB2403137
- Molecular Formula
- C5H11NSi
- Formula Weight
- 113.23
- MOL File
- 18293-53-3.mol
(TRIMETHYLSILYL)ACETONITRILE Property
- Boiling point:
- 65-70 °C20 mm Hg(lit.)
- Density
- 0.827 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.420(lit.)
- Flash point:
- 122 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Sol most common organic solvents.
- form
- Liquid
- color
- Clear colorless to straw
- Specific Gravity
- 0.829
- Hydrolytic Sensitivity
- 4: no reaction with water under neutral conditions
- BRN
- 1738845
- InChIKey
- WJKMUGYQMMXILX-UHFFFAOYSA-N
Safety
- Hazard Codes
- T
- Risk Statements
- 10-23/24/25-36/37/38
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- F
- 21
- TSCA
- No
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29310099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 3119BA
- Product name
- (Trimethylsilyl)acetonitrile
- Packaging
- 10g
- Price
- $546
- Updated
- 2021/12/16
(TRIMETHYLSILYL)ACETONITRILE Chemical Properties,Usage,Production
Physical properties
bp 84–85 °C/54 mmHg, 66 °C/35 mmHg, 65–70 °C/20 mmHg;3 d 0.827 g cm?3.
Uses
α-carbanion is a useful alternative to LiCH2CN for nucleophilic cyanomethylation; (Z)-selective Peterson alkenation). Trimethylsilylacetonitrile participates in the following synthesis reactions: Metalation, Peterson Alkenation (Cyanomethylenation), Michael Addition, Reactions with Other Electrophiles, Cyanomethylation, Metal-Catalyzed Reactions etc.
Uses
(Trimethylsilyl)acetonitrile has been used in catalytic cyanomethylation of various carbonyl compounds in the presence of Lewis bases.
Preparation
From chlorotrimethylsilane, zinc, and XCH2CN, (X = Cl, 61% yield; X = Br, 81% yield).
Purification Methods
Check if NMR and IR spectra show impurities; if present dissolve it in *C6H6 (10volumes), wash it with buffer (AcOH/AcONa pH ca 7) several times, dry (CaCl2) it, evaporate and distil it. IR: (CCl4) 2215 (CN) cm-1, NMR (CCl4): 0.23 (s, 9H, SiMe3), and 1.53 (s, 2H, CH2CN). [Matsuda et al. J Chem Soc, Perkin Trans 1 26 1979, Beilstein 4 IV 3974.]
(TRIMETHYLSILYL)ACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (TRIMETHYLSILYL)ACETONITRILE manufacturers
- Product
- (TRIMETHYLSILYL)ACETONITRILE 18293-53-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-11-17
- Product
- (Trimethylsilyl)acetonitrile 99% 18293-53-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27