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(TRIMETHYLSILYL)ACETONITRILE

Product Name
(TRIMETHYLSILYL)ACETONITRILE
CAS No.
18293-53-3
Chemical Name
(TRIMETHYLSILYL)ACETONITRILE
Synonyms
TMSAN;2-(Trimethy;Einecs 242-169-5;TRIMETHYLSILYACETONITRILE;(TRIMETHYLSILYL)ACETONITRILE;2-Trimethylsilylacetonitrile;(CYANOMETHYL)TRIMETHYLSILANE;trimethylsilanyl-acetonitrile;2-(Trimethylsilyl)acetonitrile;Acetonitrile, (trimethylsilyl)-
CBNumber
CB2403137
Molecular Formula
C5H11NSi
Formula Weight
113.23
MOL File
18293-53-3.mol
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(TRIMETHYLSILYL)ACETONITRILE Property

Boiling point:
65-70 °C20 mm Hg(lit.)
Density 
0.827 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.420(lit.)
Flash point:
122 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Sol most common organic solvents.
form 
Liquid
color 
Clear colorless to straw
Specific Gravity
0.829
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
1738845
InChI
InChI=1S/C5H11NSi/c1-7(2,3)5-4-6/h5H2,1-3H3
InChIKey
WJKMUGYQMMXILX-UHFFFAOYSA-N
SMILES
C(#N)C[Si](C)(C)C
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Safety

Hazard Codes 
T
Risk Statements 
10-23/24/25-36/37/38
Safety Statements 
26-36/37/39-45
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
F 
21
TSCA 
No
HazardClass 
3.2
PackingGroup 
III
HS Code 
29310099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

AK Scientific
Product number
3119BA
Product name
(Trimethylsilyl)acetonitrile
Packaging
10g
Price
$546
Updated
2021/12/16
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(TRIMETHYLSILYL)ACETONITRILE Chemical Properties,Usage,Production

Physical properties

bp 84–85 °C/54 mmHg, 66 °C/35 mmHg, 65–70 °C/20 mmHg;3 d 0.827 g cm?3.

Uses

α-carbanion is a useful alternative to LiCH2CN for nucleophilic cyanomethylation; (Z)-selective Peterson alkenation). Trimethylsilylacetonitrile participates in the following synthesis reactions: Metalation, Peterson Alkenation (Cyanomethylenation), Michael Addition, Reactions with Other Electrophiles, Cyanomethylation, Metal-Catalyzed Reactions etc.

Uses

(Trimethylsilyl)acetonitrile has been used in catalytic cyanomethylation of various carbonyl compounds in the presence of Lewis bases.

Preparation

From chlorotrimethylsilane, zinc, and XCH2CN, (X = Cl, 61% yield; X = Br, 81% yield).

Purification Methods

Check if NMR and IR spectra show impurities; if present dissolve it in *C6H6 (10volumes), wash it with buffer (AcOH/AcONa pH ca 7) several times, dry (CaCl2) it, evaporate and distil it. IR: (CCl4) 2215 (CN) cm-1, NMR (CCl4): 0.23 (s, 9H, SiMe3), and 1.53 (s, 2H, CH2CN). [Matsuda et al. J Chem Soc, Perkin Trans 1 26 1979, Beilstein 4 IV 3974.]

(TRIMETHYLSILYL)ACETONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (TRIMETHYLSILYL)ACETONITRILE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
(Trimethylsilyl)acetonitrile 99% 18293-53-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

18293-53-3, (TRIMETHYLSILYL)ACETONITRILERelated Search:

Bromotrimethylsilane Trimethylsilyl cyanide TRIMETHYLSILANE ETHANE Chlorine dioxide Clotrimazole Ferrous sulfate ETHYLTRIMETHYLSILANE Tetramethylsilane ETHYLDIMETHYLSILANE (TRIMETHYLSILYL)ACETONITRILE 2-Pyrrolizino-2-(trimethylsilyl)acetonitrile 2-(N-Benzyl-N-methylamino)-2-(trimethylsilyl)acetonitrile 2-(Dimethylamino)-2-(trimethylsilyl)acetonitrile 2-(Diethylamino)-2-(trimethylsilyl)acetonitrile 2-Piperidino-2-(trimethylsilyl)acetonitrile 2-(N-Benzyl-N-ethylamino)-2-(trimethylsilyl)acetonitrile 2-[N-(4-Methoxybenzyl)-N-methyl-amino]-2-(trimethylsilyl)acetonitrile

  • TMSAN
  • (TRIMETHYLSILYL)ACETONITRILE
  • trimethylsilanyl-acetonitrile
  • (Trimethylsilyl)acetonitrile,(Cyanomethyl)trimethylsilane, TMSAN
  • 2-(Trimethylsilyl)acetonitrile
  • 2-Trimethylsilylacetonitrile
  • Einecs 242-169-5
  • Acetonitrile, 2-(triMethylsilyl)-
  • (TriMethylsilyl)acetonitrile 99%
  • 2-(Trimethy
  • (CYANOMETHYL)TRIMETHYLSILANE
  • Acetonitrile, (trimethylsilyl)-
  • TRIMETHYLSILYACETONITRILE
  • (Cyanomethyl)trimethylsilane, TMSAN
  • 18293-53-3
  • CH33SiCH2CN
  • Building Blocks
  • C1 to C5
  • Nitrogen Compounds
  • Organic Building Blocks
  • Cyanides/Nitriles