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gamma-Cyclodextrin

Product Name
gamma-Cyclodextrin
CAS No.
17465-86-0
Chemical Name
gamma-Cyclodextrin
Synonyms
GAMMA-CYCLODEXTRIN;Resistant Dextrin;gammadex;CYCLOMALTOOCTAOSE;GCD;γ-CycL;gamma-CD;Ringdex C;schardinger;Cavasol? W8
CBNumber
CB9750405
Molecular Formula
C48H80O40
Formula Weight
1297.12
MOL File
17465-86-0.mol
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gamma-Cyclodextrin Property

Melting point:
≥300 °C
Boiling point:
845.2°C (rough estimate)
alpha 
[α]D25 +174~+179° (c=1, H2O) (After Drying)
Density 
1.2064 (rough estimate)
refractive index 
1.7500 (estimate)
Flash point:
450℃
storage temp. 
room temp
solubility 
1 M NaOH: 25 mg/mL, may be clear to slightly hazy
form 
powder
pka
11.68±0.70(Predicted)
color 
white
Odor
at 100.00?%. odorless
optical activity
[α]/D 174.0 to 180.0°
Water Solubility 
232g/L(25 ºC)
λmax
λ: 420 nm Amax: ≤0.20
Merck 
14,2718
BRN 
5725162
Stability:
Hygroscopic
InChIKey
GDSRMADSINPKSL-HSEONFRVSA-N
LogP
-12.02
EPA Substance Registry System
.gamma.-Cyclodextrin (17465-86-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-22
WGK Germany 
2
RTECS 
GU2293080
3
HS Code 
29400000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
779431
Product name
γ-Cyclodextrin
Purity
produced by Wacker Chemie AG, Burghausen, Germany, ≥90.0% cyclodextrin basis (HPLC)
Packaging
1kg
Price
$386
Updated
2024/03/01
Sigma-Aldrich
Product number
1154591
Product name
Gammacyclodextrin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$474
Updated
2024/03/01
TCI Chemical
Product number
C0869
Product name
gamma-Cyclodextrin
Purity
>99.0%(HPLC)
Packaging
5g
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
C0869
Product name
gamma-Cyclodextrin
Purity
>99.0%(HPLC)
Packaging
25g
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
C4930
Product name
γ-Cyclodextrin
Purity
powder, BioReagent, suitable for cell culture, ≥98%
Packaging
100mg
Price
$114
Updated
2024/03/01
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gamma-Cyclodextrin Chemical Properties,Usage,Production

Chemical Properties

White powder or crystal

Chemical Properties

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.

Uses

A molecule used to solublize non-polar molecules such a cholesterol for use in cell culture.

Uses

γ-Cyclodextrin can be used as a precursor for the synthesis of:

  • Octakis-(2,3-di-O-methyl-6-O-carboxymethyl)-γ-cyclodextrin sodium salt (ODMCM). ODMCM is used in capillary electrophoresis as a chiral resolving agent.
  • Water-soluble cyclodextrin thioethers derivatives for the transportation of hydrophobic drugs.

Uses

γ-Cyclodextrin (γ-CD), a water-soluble cyclic oligosaccharide consisting of eight α-(1,4)-linked glucopyranose subunits, can be used in a wide range of applications including:

  • Synthesis of renewable and biocompatible metal-organic frameworks.
  • Formation of inclusion complexes with a variety of guest molecules to increase their solubility in water and other polar solvents.
  • Synthesis of γ-CD based nanogels and dendrimers as carriers and stabilizers for drug delivery applications.

Definition

ChEBI: Gamma-cyclodextrin is a cycloamylose composed of eight alpha-(1->4) linked D-glucopyranose units.

Production Methods

Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.

General Description

Cyclodextrins belongs to the family of cyclic α-1,4-glucans and is made of glucose units. This molecule has a shape of a hollow cone. It possesses a hydrophilic external and hydrophobic internal surface, because of which cyclodextrins can form inclusion complexes. γ-Cyclodextrin is extensively used in food and pharmaceutical industries. Cyclodextrins are obtained by the enzymatic conversion of starch/starch derivatives by cyclodextrin glycosyltransferase.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.

Safety

Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
γ-Cyclodextrin
LD50 (rat, IP): 4.6 g/kg
LD50 (rat ,IV): 4.0 g/kg
LD50 (rat, oral): 8.0 g/kg

storage

Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.

Regulatory Status

Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

gamma-Cyclodextrin Preparation Products And Raw materials

Raw materials

Preparation Products

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gamma-Cyclodextrin Suppliers

TCI Chemicals (India) Pvt. Ltd.
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View Lastest Price from gamma-Cyclodextrin manufacturers

Hebei Jingbo New Material Technology Co., Ltd
Product
Cyclooctapentylose 17465-86-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000
Release date
2023-12-25
HebeiShuoshengImportandExportco.,Ltd
Product
Cyclooctapentylose 17465-86-0
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
gamma-Cyclodextrin 17465-86-0
Price
US $75.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-06

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