DC-CHOL

Product Name: DC-CHOL
CAS No.: 166023-21-8
Chemical Name: DC-CHOL
Synonyms: DC-CHO;DC-CHOL;DC-CHOLESTEROL;DC-Cholesterol.HCl;DC-Chol (hydrochloride);DC-cholesterol hydrochloride;Cholesteryl 3β-N-(dimethylaminoethyl)carbamate;cholesteryl 3B-(N-(dimethylaminoethyl)*carbamate);3β-[n-(dimethylaminoethane) carbamoyl] cholesterol;Cholesteryl 3β-N-(di-methyl-amino-ethyl)-carbamate
CBNumber: CB9751215
Molecular Formula: C29H51ClN2O2
Formula Weight: 495.18
MOL File: 166023-21-8.mol

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DC-CHOL Property

storage temp.: -20°C
solubility: DMSO: > 5mg/mL; Methanol: > 10 mg/mL
form: A crystalline solid

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2832
Product name: Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride
Purity: ≥95%
Packaging: 25mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2832
Product name: Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride
Purity: ≥95%
Packaging: 100mg
Price: $240
Updated: 2024/03/01

Cayman Chemical

Product number: 16943
Product name: DC-Chol (hydrochloride)
Packaging: 50mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 16943
Product name: DC-Chol (hydrochloride)
Packaging: 250mg
Price: $486
Updated: 2024/03/01

Cayman Chemical

Product number: 16943
Product name: DC-Chol (hydrochloride)
Packaging: 25mg
Price: $63
Updated: 2024/03/01

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DC-CHOL Chemical Properties,Usage,Production

Description

DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE , has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.

Uses

This cationic cholesterol derivative forms liposomes with L-α-phosphatidylethanolamine, dioleoyl, that efficiently transfect mammalian cell lines.

Uses

DC-Cholesterol HCl is suitable:

for the preparation of ultrasound cationic microbubbles
to prepare liposomes
for the preparation of L-glutathione (GSH), loaded proliposomes

General Description

DC-Cholesterol HCl is a sterol-based transfection reagent.

Biochem/physiol Actions

DC-Cholesterol is an effective transfection agent and a liposome reagent. Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection. It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).

storage

Store at -20°C

DC-CHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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DC-CHOL Suppliers

China 44 South Korea 1 Switzerland 1 United States 7 Global 53

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

ShenZhen InnoSyn Biotech Co.,Ltd

Tel: 0755-28351685 18503098468
Fax: +86-755-28466854
Email: innosyn@163.com
Country: China
ProdList: 600
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

Shanghai AECOM Biotechnology Co. , Ltd.

Tel: 021-021-20956531 18116226605
Fax: 021-20956532
Email: sui@neosunpharm.com
Country: China
ProdList: 350
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Hunan chemfish Scientific co.,ltd

Tel: 0731-85567275 15528049369
Email: sales@chemfish.com
Country: China
ProdList: 4917
Advantage: 58

Shochem(Shanghai)Co.,Ltd

Tel: +86-021-51783479 +86-13816874662
Fax: 021-50800795
Email: info@shochem.com
Country: China
ProdList: 311
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 12722
Advantage: 58

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166023-21-8

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