2-(2-Aminoethyl)isothiourea dihydrobromide

ChemicalBook > CAS DataBase List > 2-(2-Aminoethyl)isothiourea dihydrobromide

2-(2-Aminoethyl)isothiourea dihydrobromide

?Synthesis

Product Name: 2-(2-Aminoethyl)isothiourea dihydrobromide
CAS No.: 56-10-0
Chemical Name: 2-(2-Aminoethyl)isothiourea dihydrobromide
Synonyms: AET;ixecur;usafxr-31;surrectan;ANTIRADON;NSC 22877;AET, DiHBr;AET-NSC-22877;AET, DIHYDROBROMIDE;IFLAB-BB F0861-0023
CBNumber: CB9753183
Molecular Formula: C3H11Br2N3S
Formula Weight: 281.01
MOL File: 56-10-0.mol

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2-(2-Aminoethyl)isothiourea dihydrobromide Property

Melting point:: 190-196 °C(lit.)
Density: 1.94 g/cm3
storage temp.: Store below +30°C.
solubility: 50g/l
form: powder to crystal
color: White to Almost white
Water Solubility: almost transparency
Merck: 14,178
BRN: 3911163
CAS DataBase Reference: 56-10-0(CAS DataBase Reference)
EPA Substance Registry System: Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide (56-10-0)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37-22
WGK Germany: 3
RTECS: UM0175000
F: 10-21
TSCA: Yes
HS Code: 2930 90 98
Toxicity: LD50 in mice (mg/kg): 100 i.v., 280 s.c., 480 i.p., 1600 orally (Pospisil)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A5879
Product name: 2-(2-Aminoethyl)isothiourea dihydrobromide
Packaging: 25g
Price: $98.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20064
Product name: S-(2-Aminoethyl)thiouronium bromide hydrobromide
Purity: for synthesis
Packaging: 10g
Price: $68.2
Updated: 2024/03/01

TCI Chemical

Product number: A1078
Product name: S-(2-Aminoethyl)isothiouronium Bromide Hydrobromide
Purity: >98.0%(T)
Packaging: 25g
Price: $55
Updated: 2024/03/01

Alfa Aesar

Product number: L14232
Product name: S-(2-Aminoethyl)isothiourea dihydrobromide, 98%
Packaging: 5g
Price: $21.65
Updated: 2024/03/01

Alfa Aesar

Product number: L14232
Product name: S-(2-Aminoethyl)isothiourea dihydrobromide, 98%
Packaging: 25g
Price: $56.65
Updated: 2024/03/01

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2-(2-Aminoethyl)isothiourea dihydrobromide Chemical Properties,Usage,Production

?Synthesis

Ethylamine thiourea is synthesized by using cycloethylamine, hydrobromic acid and thiourea as raw materials: firstly, thiourea is mixed with hydrogen bromide acid, and cycloethylamine is added dropwise at a temperature below 150 °C. After the reaction is completed, add activated carbon to filter, and then reduce Dehydration under pressure, crystals are precipitated when the temperature is below 50°C, filtered, and washed twice with absolute ethanol.

Description

S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the K_i values are 1.8, 2.1, and 0.59 μM, respectively.

Chemical Properties

Crystals, hygroscopic.

Uses

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

Uses

Has radioprotective activity against x-rays.

Uses

NOS inhibitor

Purification Methods

Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].

References

[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76.

2-(2-Aminoethyl)isothiourea dihydrobromide Preparation Products And Raw materials

Raw materials

Monoethanolamine Hydrogen bromide 2-Bromoethylamine hydrobromide Ethyleneimine

Preparation Products

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View Lastest Price from 2-(2-Aminoethyl)isothiourea dihydrobromide manufacturers

Dideu Industries Group Limited

Product: 2-(2-Aminoethyl)isothiourea dihydrobromide 56-10-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-27

Career Henan Chemical Co

Product: 2-(2-Aminoethyl)isothiourea dihydrobromide 56-10-0
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-26

56-10-0, 2-(2-Aminoethyl)isothiourea dihydrobromideRelated Search:

N-Aminothiourea 1-PHENYL-2-THIOUREA 2-(2-Aminoethylamino)ethanol Dextromethorphan hydrobromide monohydrate Thiourea PHENAZINE ETHOSULFATE Allyl bromide Rocuronium bromide Galantamine Hydrobromide N,N'-Diethylthiourea N-Aminoethylpiperazine Ethylamine Hydrogen bromide Pyridine hydrobromide Sodium bromate Ethidium bromide Ethylamine hydrochloride Methyl bromide

s-(beta-aminoethyl)isothiuroniumbromidehydrobromide

s-aminoethylisothiuroniumbromidehydrobromide

s-beta-aminoethylisothiuroniumbromohydrate

surrectan

usafxr-31

(2-aminoethyl)-2-thio-pseudouredihydrobromide

2-(2-aminoethyl)-2-thiopseudoureahydrobromide

2-(beta-aminoethyl)isothiouroniumbromidehydrobromide

2-aminoethylisothiourea

2-aminoethylisothioureahydrobromide

2-aminoethylisothiouroniumdibromide

2-aminoethylisothiuroniumbromidehydrobromide

2-aminoethylisothiuroniumdihydrobromide

2-aminoethylthiopseudoureadihydrobromide

-Aminoethyl-iso-thiouranium

aminoethylisothiuroniumbromidehydrobromide

beta-aminoaethyl-isothiuroniumdihydrobromid

beta-aminoethylisothiuroniumbromidehydrobromide

ixecur

s-(2-aminoaethyl)isothiuroniumdibromid

S-(2-Aminoethyl)-iso-thio-uraniumbromidehydrobromide

s-(2-aminoethyl)isothiouroniumbromidehydrobromi

s-(2-aminoethyl)isothiuroniumdibromide

s-(2-aminoethyl)pseudothioureadihydrobromide

AET

AET, DIHYDROBROMIDE

IFLAB-BB F0861-0023

CARBAMIMIDOTHIOIC ACID 2-AMINOETHYL ESTER DIHYDROBROMIDE

ANTIRADON

BETA-AMINOETHYLISOTHIOURONIUM BROMIDE HYDROBROMIDE

2-(2-aminoethyl)isothiourea dihydrobromide

2-(2-AMINOETHYL)-2-THIOPSEUDO-UREA 2HBR

2-(2-AMINOETHYL)-2-THIOPSEUDOUREA DIHYDROBROMIDE

2-AMINOETHYL CARBAMIMIDOTHIOATE, DIHYDROBROMIDE

2-AMINOETHYL IMIDOTHIOCARBAMATE DIHYDROBROMIDE

2-AMINOETHYLISOTHIOURONIUM BR

2-AMINOETHYLISOTHIOURONIUM BROMIDE

2-AMINOETHYLISOTHIOURONIUM BROMIDE HYDROBROMIDE

S-(2-Aminoethyl)thiouronium bromide hydrobromide for synthesis

S-(2-AMINOETHYL)ISOTHIOUREA 2HBR

S-(2-AMINOETHYL)ISOTHIOUREA DIHYDROBROMIDE

S-(2-AMINOETHYL)ISOTHIOURONIUM BROMIDE HYDROBROMIDE

carbamimidothioic acid 2-aminoethyl ester bromide

S-(2-AMINOETHYL)ISOTHIOURONIUM HYDROGEN-BROMIDE

S(-2-AMINOETHYL)-ITU DIHYDROBROMIDE

S-(2-AMINOETHYL)THIOURONIUM BROMIDE HYDROBROMIDE

NSC 22877

2-(2-Aminoethyl)-2-Thiopseudorea Dihydrobromide

AET, DiHBr

AET~S-(2-Aminoethyl)isothiouronium bromide dihydrobromide

S-(2-AMINOETHYL)ISOTHIOURONIUM BROMIDE &

s-(2-aminoethyl)isothiouronium bromide dihydrobromide

2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide, AET, S-(2-Aminoethyl)isothiouronium bromide hydrobromide

AET-NSC-22877

S-(2-Aminoethyl)isothiuronium bromide hydrobromide

(E)-1-(2-Aminoethyl)isothiouroniumbromidehydrobromide

2-(2-Aminoethyl)isot

S-(2-AMINOETHYL)ISOTHIOURONIUMDIBROMIDE