2-(2-Aminoethyl)isothiourea dihydrobromide
?Synthesis- Product Name
- 2-(2-Aminoethyl)isothiourea dihydrobromide
- CAS No.
- 56-10-0
- Chemical Name
- 2-(2-Aminoethyl)isothiourea dihydrobromide
- Synonyms
- AET;ixecur;usafxr-31;surrectan;ANTIRADON;NSC 22877;AET, DiHBr;AET-NSC-22877;AET, DIHYDROBROMIDE;IFLAB-BB F0861-0023
- CBNumber
- CB9753183
- Molecular Formula
- C3H11Br2N3S
- Formula Weight
- 281.01
- MOL File
- 56-10-0.mol
2-(2-Aminoethyl)isothiourea dihydrobromide Property
- Melting point:
- 190-196 °C(lit.)
- Density
- 1.94 g/cm3
- storage temp.
- Store below +30°C.
- solubility
- 50g/l
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- almost transparency
- Merck
- 14,178
- BRN
- 3911163
- CAS DataBase Reference
- 56-10-0(CAS DataBase Reference)
- EPA Substance Registry System
- Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide (56-10-0)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37-22
- WGK Germany
- 3
- RTECS
- UM0175000
- F
- 10-21
- TSCA
- Yes
- HS Code
- 2930 90 98
- Toxicity
- LD50 in mice (mg/kg): 100 i.v., 280 s.c., 480 i.p., 1600 orally (Pospisil)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A5879
- Product name
- 2-(2-Aminoethyl)isothiourea dihydrobromide
- Packaging
- 25g
- Price
- $98.5
- Updated
- 2024/03/01
- Product number
- 8.20064
- Product name
- S-(2-Aminoethyl)thiouronium bromide hydrobromide
- Purity
- for synthesis
- Packaging
- 10g
- Price
- $68.2
- Updated
- 2024/03/01
- Product number
- A1078
- Product name
- S-(2-Aminoethyl)isothiouronium Bromide Hydrobromide
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $55
- Updated
- 2024/03/01
- Product number
- L14232
- Product name
- S-(2-Aminoethyl)isothiourea dihydrobromide, 98%
- Packaging
- 5g
- Price
- $21.65
- Updated
- 2024/03/01
- Product number
- L14232
- Product name
- S-(2-Aminoethyl)isothiourea dihydrobromide, 98%
- Packaging
- 25g
- Price
- $56.65
- Updated
- 2024/03/01
2-(2-Aminoethyl)isothiourea dihydrobromide Chemical Properties,Usage,Production
?Synthesis
Ethylamine thiourea is synthesized by using cycloethylamine, hydrobromic acid and thiourea as raw materials: firstly, thiourea is mixed with hydrogen bromide acid, and cycloethylamine is added dropwise at a temperature below 150 °C. After the reaction is completed, add activated carbon to filter, and then reduce Dehydration under pressure, crystals are precipitated when the temperature is below 50°C, filtered, and washed twice with absolute ethanol.
Description
S-
Chemical Properties
Crystals, hygroscopic.
Uses
2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).
Uses
Has radioprotective activity against x-rays.
Uses
NOS inhibitor
Purification Methods
Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].
References
[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76.
2-(2-Aminoethyl)isothiourea dihydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(2-Aminoethyl)isothiourea dihydrobromide manufacturers
- Product
- 2-(2-Aminoethyl)isothiourea dihydrobromide 56-10-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-27
- Product
- 2-(2-Aminoethyl)isothiourea dihydrobromide 56-10-0
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-26