ChemicalBook > CAS DataBase List > (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

Product Name: (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
CAS No.: 131878-23-4
Chemical Name: (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
Synonyms: (R)-1-Benzyl-3-NBoc-aMinopyrrolidin;(R)-1-BENZYL-3-N-BOC-AMINO-PYRROLIDINE;TERT-BUTYL(R)-1-BENZYLPYRROLIDIN-3-YLCARBAMATE;(R)-Tert-butyl 1-benzylpyrrolidin-3-ylcarbamate;(R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine;tert-butyl N-[(3R)-1-benzylpyrrolidin-3-yl]carbamate;(R)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(R)-1-BENZLY-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(R)-(1-BENZYL-PYRROLIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CBNumber: CB9763580
Molecular Formula: C16H24N2O2
Formula Weight: 276.37
MOL File: 131878-23-4.mol

Less

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Property

Melting point:: 77-81 °C(lit.)
Boiling point:: 385.1±31.0 °C(Predicted)
Density: 1.08
refractive index: 18.5 ° (C=2, EtOH)
storage temp.: 2-8°C
solubility: almost transparency in Methanol
form: powder to crystal
pka: 12.31±0.20(Predicted)
color: White to Almost white
optical activity: [α]20/D +6°, c = 1% in chloroform
CAS DataBase Reference: 131878-23-4(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 649961
Product name: (R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine
Purity: 97%
Packaging: 1g
Price: $68.7
Updated: 2023/01/07

TCI Chemical

Product number: B1932
Product name: (3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TRC

Product number: B750238
Product name: (R)-tert-Butyl(1-Benzylpyrrolidin-3-yl)carbamate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Chem-Impex

Product number: 41587
Product name: (R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $67.56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB60242
Product name: (3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Packaging: 2g
Price: $69
Updated: 2021/12/16

Less

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Chemical Properties,Usage,Production

Synthesis

24424-99-5

114715-39-8

131878-23-4

The general procedure for the synthesis of (R)-1-benzyl-3-(tert-butoxycarbonylamino)pyrrolidine from di-tert-butyl dicarbonate and (R)-1-benzyl-3-amino pyrrolidine was as follows: first, sodium bicarbonate (5.92 g, 70.5 mmol) was dissolved in 118 mL of deionized water, and then this solution was added to a 118 mL acetonitrile solution of (R)-(+)-benzylamino pyrrolidine 1a (5.00 g, 28.4 mmol) in 118 mL of acetonitrile solution. The mixture was stirred at room temperature for 10 minutes. Subsequently, di-tert-butyl dicarbonate (6.22 g, 28.5 mmol) was added and stirring was continued overnight at room temperature. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the residue was extracted three times with dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (eluent ratio methanol: dichloromethane = 2:98). Finally, the solvent was removed in vacuum to afford 4.24 g of tert-butyl (R)-(1-benzylpyrrolidin-3-yl)carbamate in 65.2% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.36-7.26 (m, 5H), 4.86 (bs, 1H), 4.18 (bs, 1H), 3.61 (s, 2H), 2.79 (bs, 1H), 2.65-2.61 (m, 1H), 2.54 (d, J=8.0 Hz, 1H), 2.34- 2.25 (m, 2H), 1.61-1.51 (m, 1H), 1.46 (s, 9H). The specific optical rotation [α]D was +2.5° (c 0.620, CHCl3).

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1495 - 1510
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 11, p. 1815 - 1826
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 3, p. 721 - 739

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Suppliers

Americas 1 China 73 Europe 1 Germany 3 India 2 Japan 1 Switzerland 1 United Kingdom 3 United States 16 Global 101

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.

Tel: 028-85755578 18140172005
Fax: 028-85755578
Email: sales@aminotp.com
Country: China
ProdList: 298
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Hangzhou Huarong Pharm Co., Ltd.

Tel: 571-86758373 +8613588754946
Fax: 0086-571-81131109
Email: sales@huarongpharm.com
Country: CHINA
ProdList: 3148
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Blocksynth Pharmaceutical Technology Co.,Ltd

Tel: 0086-19817745290; +8619817745290
Email: bd@blocksynth.com
Country: China
ProdList: 5661
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Guizhou Yituo Chemical Technology Co., Ltd

Tel: 18628235590
Fax: QQ:444176500
Email: wuliming@yituochem.cn
Country: China
ProdList: 1242
Advantage: 58

Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo

Tel: 18584079237
Email: 312074905@qq.com
Country: China
ProdList: 2513
Advantage: 58

Chengdu Zokrio Pharmaceutical Co., Ltd

Tel: 18190925036
Email: 2875752953@qq.com
Country: China
ProdList: 478
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Lingyuan Bebiansen Biological Technology Co., Ltd

Tel: 18642120371
Email: 2837458851@qq.com
Country: China
ProdList: 7963
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Nanjing Wogni Chemical Co., Ltd.

Tel: 15996452985
Email: foxerhy@163.com
Country: China
ProdList: 4939
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 9967
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Auonsi (Shanghai) Biology Technology Co., Ltd.

Tel: 400-1107768 15058188853
Fax: 0571-88150696
Email: 478133536@qq.com
Country: China
ProdList: 8552
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd.

Tel: 18560864701
Email: 643971@qq.com
Country: China
ProdList: 6098
Advantage: 58

Less

View Lastest Price from (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE manufacturers

Career Henan Chemical Co

Product: (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 131878-23-4
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

131878-23-4, (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINERelated Search:

1-BENZYL-3-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID (S)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE (3R)-(+)-3-(METHYLAMINO)PYRROLIDINE 1-Benzyl-3-aminopyrrolidine 2-((R)-3-(tert-butoxycarbonylamino)pyrrolidin-1-yl)-2-m-tolylacetic acid (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE TRANS-1-BENZYL-4-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID,TRANS-RACEMIC-1-BENZYL-4-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID (S)-3-BOC-AMINO-BUTYLAMINE (S)-3-(Boc-amino)pyrrolidine (3-BENZYLAMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI) 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE (3R)-(-)-1-BENZYL-3-(METHYLAMINO)PYRROLIDINE (S)-(+)-1-Benzyl-3-aminopyrrolidine 3-N-Boc-aminopyrrolidine Carbamic acid, [3-(propylamino)propyl]-, 1,1-dimethylethyl ester (9CI)

(R)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

(R)-(1-BENZYL-PYRROLIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine

tert-butyl N-[(3R)-1-benzylpyrrolidin-3-yl]carbamate

TERT-BUTYL(R)-1-BENZYLPYRROLIDIN-3-YLCARBAMATE

CARBAMIC ACID,[(3R)-1-(PHENYLMETHYL)-3-PYRROLIDINYL]-,1,1-DIMETHYLETHYL ESTER

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 98+%

(R)-1-BENZLY-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

(R)-1-BENZYL-3-N-BOC-AMINO-PYRROLIDINE

(R)-Tert-butyl 1-benzylpyrrolidin-3-ylcarbamate

(R)-1-Benzyl-3-NBoc-aMinopyrrolidin

[(3R)-1-(Phenylmethyl)-3-pyrrolidinyl]-carbamic acid 1,1-dimethylethyl ester

(3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine &gt

Carbamic acid, N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester

(3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine/(R)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine

(R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine

131878-23-4

3-Aminopyrrolidines

Chiral 3-Aminopyrrolidines

Chiral Building Blocks

Asymmetric Synthesis

Pyrrolidines

Heterocyclic Building Blocks

3-Aminopyrrolidines

Chiral 3-Aminopyrrolidines