(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
- Product Name
- (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
- CAS No.
- 131878-23-4
- Chemical Name
- (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
- Synonyms
- (R)-1-Benzyl-3-NBoc-aMinopyrrolidin;(R)-1-BENZYL-3-N-BOC-AMINO-PYRROLIDINE;TERT-BUTYL(R)-1-BENZYLPYRROLIDIN-3-YLCARBAMATE;(R)-Tert-butyl 1-benzylpyrrolidin-3-ylcarbamate;(R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine;tert-butyl N-[(3R)-1-benzylpyrrolidin-3-yl]carbamate;(R)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(R)-1-BENZLY-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(R)-(1-BENZYL-PYRROLIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CBNumber
- CB9763580
- Molecular Formula
- C16H24N2O2
- Formula Weight
- 276.37
- MOL File
- 131878-23-4.mol
(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Property
- Melting point:
- 77-81 °C(lit.)
- Boiling point:
- 385.1±31.0 °C(Predicted)
- Density
- 1.08
- refractive index
- 18.5 ° (C=2, EtOH)
- storage temp.
- 2-8°C
- solubility
- almost transparency in Methanol
- form
- powder to crystal
- pka
- 12.31±0.20(Predicted)
- color
- White to Almost white
- optical activity
- [α]20/D +6°, c = 1% in chloroform
- CAS DataBase Reference
- 131878-23-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 649961
- Product name
- (R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $68.7
- Updated
- 2023/01/07
- Product number
- B1932
- Product name
- (3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- B750238
- Product name
- (R)-tert-Butyl(1-Benzylpyrrolidin-3-yl)carbamate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB60242
- Product name
- (3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 126404
- Product name
- (R)-tert-Butyl (1-benzylpyrrolidin-3-yl)carbamate
- Purity
- >95%
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Chemical Properties,Usage,Production
Synthesis
24424-99-5
114715-39-8
131878-23-4
The general procedure for the synthesis of (R)-1-benzyl-3-(tert-butoxycarbonylamino)pyrrolidine from di-tert-butyl dicarbonate and (R)-1-benzyl-3-amino pyrrolidine was as follows: first, sodium bicarbonate (5.92 g, 70.5 mmol) was dissolved in 118 mL of deionized water, and then this solution was added to a 118 mL acetonitrile solution of (R)-(+)-benzylamino pyrrolidine 1a (5.00 g, 28.4 mmol) in 118 mL of acetonitrile solution. The mixture was stirred at room temperature for 10 minutes. Subsequently, di-tert-butyl dicarbonate (6.22 g, 28.5 mmol) was added and stirring was continued overnight at room temperature. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the residue was extracted three times with dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (eluent ratio methanol: dichloromethane = 2:98). Finally, the solvent was removed in vacuum to afford 4.24 g of tert-butyl (R)-(1-benzylpyrrolidin-3-yl)carbamate in 65.2% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.36-7.26 (m, 5H), 4.86 (bs, 1H), 4.18 (bs, 1H), 3.61 (s, 2H), 2.79 (bs, 1H), 2.65-2.61 (m, 1H), 2.54 (d, J=8.0 Hz, 1H), 2.34- 2.25 (m, 2H), 1.61-1.51 (m, 1H), 1.46 (s, 9H). The specific optical rotation [α]D was +2.5° (c 0.620, CHCl3).
References
[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1495 - 1510
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 11, p. 1815 - 1826
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 3, p. 721 - 739
(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Suppliers
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View Lastest Price from (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE manufacturers
- Product
- (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 131878-23-4
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25