biological activity
ChemicalBook > CAS DataBase List > 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID

4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID

biological activity
Product Name
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
CAS No.
331830-20-7
Chemical Name
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
Synonyms
4-DPCA;1,4-DPCA;TVBAVFFTADCWKG-UHFFFAOYSA-N;4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID;4-Oxo-4,4a-dihydro-1,10-phenanthroline-3-carboxylic acid;1,10-Phenanthroline-3-carboxylic acid, 4,4a-dihydro-4-oxo-;HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIF-1α,HIFs,FIH,P4HA1,P4HA2,1,4DPCA,healing,Inhibitor,Hypoxia-inducible factors,1,4 DPCA,wound,inhibit,1,4-DPCA,P4HA3
CBNumber
CB9765690
Molecular Formula
C13H8N2O3
Formula Weight
240.21
MOL File
331830-20-7.mol
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4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Property

Boiling point:
419.5±45.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
RT
solubility 
Soluble in DMSO (up to 15 mg/ml with warming).
form 
Tan solid.
pka
2.55±0.20(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
71220
Product name
1,4-DPCA
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
71220
Product name
1,4-DPCA
Purity
≥98%
Packaging
10mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
71220
Product name
1,4-DPCA
Purity
≥98%
Packaging
25mg
Price
$190
Updated
2024/03/01
Cayman Chemical
Product number
71220
Product name
1,4-DPCA
Purity
≥98%
Packaging
50mg
Price
$333
Updated
2024/03/01
TRC
Product number
D585820
Product name
1,4-DPCA
Packaging
50mg
Price
$125
Updated
2021/12/16
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4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

biological activity

1,4-DPCA, a potent and selective inhibitor of prolyl-4-hydroxylase, is also an inhibitor of collagen hydroxylation in chemicalbook cells of human foreskin fibroblasts with IC50 of 2.4µM. 1,4-DPCA inhibits the alpha isoform of prolyl-4-hydroxylase and stabilizes HIF-1alpha protein.

Description

1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM).1 Inhibits collagen deposition via inhibition of collagen proline hydroxylation.2,3 Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1α over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury.4

Uses

1,4-DPCA nis a potent competitive inhibitor of avian prolyl 4-hydroxylase in embryonic chick tendon cells and human foreskin fibroblasts in vitro. It is a promotor of wound healing and tissue regeneration in mice.

References

1) Franklin?et al. (2001),?Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones; Biochem. J.,?353?333 2) Xiong?et al. (2014),?Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition; BMC Cancer,?14?1 3) Love and Jones?et al. (2013),?Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs; J. Biomed. Mater. Res.,?101?3599 4) Zhang?et al. (2015),?Drug induced regeneration in adult mice; Sci. Transl. Med.,?7?290ra92

4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID Suppliers

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331830-20-7, 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACIDRelated Search:

DY131 mycotrienin II SALUBRINAL SU 4312 Chrysin QUINOMYCIN A Anifostine trihydrate CHAETOMIN BISPHENOL A DIMETHYL ETHER 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID ETHYL ESTER 8-AMINO-7-METHYL-QUINOLINE 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID

  • 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
  • 1,4-DPCA
  • TVBAVFFTADCWKG-UHFFFAOYSA-N
  • 4-DPCA
  • HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIF-1α,HIFs,FIH,P4HA1,P4HA2,1,4DPCA,healing,Inhibitor,Hypoxia-inducible factors,1,4 DPCA,wound,inhibit,1,4-DPCA,P4HA3
  • 1,10-Phenanthroline-3-carboxylic acid, 4,4a-dihydro-4-oxo-
  • 4-Oxo-4,4a-dihydro-1,10-phenanthroline-3-carboxylic acid
  • 331830-20-7