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CHAETOMIN

Product Name
CHAETOMIN
CAS No.
1403-36-7
Chemical Name
CHAETOMIN
Synonyms
CTM;19A;CS-1;HSF4;SSFA2;CMH16;CRACC;C4orf5;UNQ576;PRO1138
CBNumber
CB4173948
Molecular Formula
C31H30N6O6S4
Formula Weight
710.87
MOL File
1403-36-7.mol
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CHAETOMIN Property

Melting point:
218-220℃ (chloroform )
Density 
1.78±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
Off-white to fawn solid.
pka
12.69±0.10(Predicted)
color 
Off-white to fawn
biological source
mouse
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Toxicity
rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB1412167
Product name
ANTI-HSF4 antibody produced in mouse
Purity
clone 2A2, purified immunoglobulin, buffered aqueous solution
Packaging
100 μg
Price
$541
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB1412151
Product name
ANTI-HSF4 antibody produced in mouse
Purity
clone 2B3, purified immunoglobulin, buffered aqueous solution
Packaging
100 μg
Price
$541
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB1403947
Product name
Monoclonal Anti-HSF4 antibody produced in mouse
Purity
clone 3G3, purified immunoglobulin, buffered aqueous solution
Packaging
100μg
Price
$541
Updated
2025/07/31
Sigma-Aldrich
Product number
C9623
Product name
Chetomin
Purity
from Chaetomium cochliodes, ≥98% (HPLC)
Packaging
1mg
Price
$246.52
Updated
2025/07/31
Sigma-Aldrich
Product number
C9623
Product name
Chetomin
Purity
from Chaetomium cochliodes, ≥98% (HPLC)
Packaging
5mg
Price
$817
Updated
2025/07/31
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CHAETOMIN Chemical Properties,Usage,Production

Uses

Chetomin is an antibacterial agent and inhibitor of HIF.

Definition

ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.

Biochem/physiol Actions

Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.

in vivo

Chetomin (0~100 mg/kg; p.o.) inhibits lung tumorigenesis in NSCLC mouse models[1].
Chetomin markedly decreases tumor formation in several murine models of NSCLC[1].

Animal Model:Mouse
Dosage:0~100 mg/kg
Administration:P.o.
Result:Inhibited lung tumorigenesis in NSCLC mouse models.

IC 50

HSP90

storage

+4°C

CHAETOMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CHAETOMIN Suppliers

China 94 Germany 3 Switzerland 1 United Kingdom 4 United States 16 USA 1 Global 119
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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96815
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
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China
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35896
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AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
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58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
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55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
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China
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51395
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80
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
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8447
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60
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
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526763801@qq.com
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China
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9273
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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60
Lynnchem
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86-(0)29-85992781 17792393971
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info@lynnchem.com
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China
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4587
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1403-36-7, CHAETOMINRelated Search:

Chrysin QUINOMYCIN A Anifostine trihydrate BISPHENOL A DIMETHYL ETHER (3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE (3R)-(+)-3-(ETHYLAMINO)PYRROLIDINE [2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYL]METHYLAMINE 1H-Indol-2-amine 1-Piperazineethanamine,-alpha-,-alpha-,4-trimethyl-(9CI) HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE CHAETOMIN BENZENEMETHANAMINE, 2-AMINO-ALPHA,ALPHA-DIMETHYL CHEMBRDG-BB 4012298 2-(3-PHENYL-PYRROLIDIN-1-YL)-ETHYLAMINE CYCLO(-D-ALA-D-ALA) 2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYLAMINE (S)-2-HYDROXYMETHYL-PIPERAZINE 1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE

  • CTM
  • CS-1
  • CHETOMIN
  • CHAETOMIN
  • Chetomin,Chaetomin
  • Chetomin,Chaetomiumspecies
  • CHETOMIN(RG)
  • NSC 289491
  • Stereoisomer of 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
  • Monoclonal Anti-HSF4 antibody produced in mouse
  • DKFZp313O1039
  • SSFA2
  • ANTI-HSF4 antibody produced in mouse
  • HSF4
  • (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
  • Chetomin (NSC 289491)
  • 3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-, (3S,5aR,10bS,11aS)-
  • NSC289491， BRN0077366
  • Rabbit Anti-HSF4 antibody
  • Chetomin, HIF signaling inhibitor
  • Chetomin, <i>Chaetomium</i> sp.
  • C4orf5
  • CMH16
  • 19A
  • CRACC
  • PRO1138
  • UNQ576
  • 1403-36-7
  • C31H30N6O6S4