CHAETOMIN

Product Name: CHAETOMIN
CAS No.: 1403-36-7
Chemical Name: CHAETOMIN
Synonyms: CTM;CS-1;HSF4;SSFA2;CHETOMIN;CHAETOMIN;NSC 289491;CHETOMIN(RG);DKFZp313O1039;Chetomin,Chaetomin
CBNumber: CB4173948
Molecular Formula: C31H30N6O6S4
Formula Weight: 710.87
MOL File: 1403-36-7.mol

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CHAETOMIN Property

Melting point:: 218-220℃ (chloroform )
Density: 1.78±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble
form: Off-white to fawn solid.
pka: 12.69±0.10(Predicted)
color: Off-white to fawn

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Toxicity: rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9623
Product name: Chetomin
Purity: from Chaetomium cochliodes, ≥98% (HPLC)
Packaging: 1mg
Price: $265
Updated: 2024/03/01

Sigma-Aldrich

Product number: SAB1403947
Product name: Monoclonal Anti-HSF4 antibody produced in mouse
Purity: clone 3G3, purified immunoglobulin, buffered aqueous solution
Packaging: 100μg
Price: $524
Updated: 2024/03/01

Sigma-Aldrich

Product number: C9623
Product name: Chetomin
Purity: from Chaetomium cochliodes, ≥98% (HPLC)
Packaging: 5mg
Price: $792
Updated: 2024/03/01

Cayman Chemical

Product number: 14437
Product name: Chetomin
Purity: ≥95%
Packaging: 1mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 14437
Product name: Chetomin
Purity: ≥95%
Packaging: 5mg
Price: $549
Updated: 2024/03/01

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CHAETOMIN Chemical Properties,Usage,Production

Uses

Chetomin is an antibacterial agent and inhibitor of HIF.

Definition

ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.

Biochem/physiol Actions

Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.

storage

+4°C

CHAETOMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CHAETOMIN Suppliers

China 72 Germany 3 Switzerland 1 United Kingdom 4 United States 15 USA 1 Global 96

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

1403-36-7, CHAETOMINRelated Search:

Chrysin QUINOMYCIN A Anifostine trihydrate BISPHENOL A DIMETHYL ETHER (3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE (3R)-(+)-3-(ETHYLAMINO)PYRROLIDINE [2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYL]METHYLAMINE 1H-Indol-2-amine 1-Piperazineethanamine,-alpha-,-alpha-,4-trimethyl-(9CI) HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE CHAETOMIN BENZENEMETHANAMINE, 2-AMINO-ALPHA,ALPHA-DIMETHYL CHEMBRDG-BB 4012298 2-(3-PHENYL-PYRROLIDIN-1-YL)-ETHYLAMINE CYCLO(-D-ALA-D-ALA) 2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYLAMINE (S)-2-HYDROXYMETHYL-PIPERAZINE 1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE

CTM

CS-1

CHETOMIN

CHAETOMIN

Chetomin,Chaetomin

Chetomin,Chaetomiumspecies

CHETOMIN(RG)

NSC 289491

Stereoisomer of 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Monoclonal Anti-HSF4 antibody produced in mouse

DKFZp313O1039

SSFA2

ANTI-HSF4 antibody produced in mouse

HSF4

(3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Chetomin (NSC 289491)

3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-, (3S,5aR,10bS,11aS)-

NSC289491， BRN0077366

Rabbit Anti-HSF4 antibody

1403-36-7

C31H30N6O6S4