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CHAETOMIN

Product Name
CHAETOMIN
CAS No.
1403-36-7
Chemical Name
CHAETOMIN
Synonyms
CTM;CS-1;HSF4;SSFA2;CHETOMIN;CHAETOMIN;NSC 289491;CHETOMIN(RG);DKFZp313O1039;Chetomin,Chaetomin
CBNumber
CB4173948
Molecular Formula
C31H30N6O6S4
Formula Weight
710.87
MOL File
1403-36-7.mol
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CHAETOMIN Property

Melting point:
218-220℃ (chloroform )
Density 
1.78±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
Off-white to fawn solid.
pka
12.69±0.10(Predicted)
color 
Off-white to fawn
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Toxicity
rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C9623
Product name
Chetomin
Purity
from Chaetomium cochliodes, ≥98% (HPLC)
Packaging
1mg
Price
$265
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB1403947
Product name
Monoclonal Anti-HSF4 antibody produced in mouse
Purity
clone 3G3, purified immunoglobulin, buffered aqueous solution
Packaging
100μg
Price
$524
Updated
2024/03/01
Sigma-Aldrich
Product number
C9623
Product name
Chetomin
Purity
from Chaetomium cochliodes, ≥98% (HPLC)
Packaging
5mg
Price
$792
Updated
2024/03/01
Cayman Chemical
Product number
14437
Product name
Chetomin
Purity
≥95%
Packaging
1mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
14437
Product name
Chetomin
Purity
≥95%
Packaging
5mg
Price
$549
Updated
2024/03/01
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CHAETOMIN Chemical Properties,Usage,Production

Uses

Chetomin is an antibacterial agent and inhibitor of HIF.

Definition

ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.

Biochem/physiol Actions

Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.

storage

+4°C

CHAETOMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CHAETOMIN Suppliers

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1403-36-7, CHAETOMINRelated Search:

Chrysin QUINOMYCIN A Anifostine trihydrate BISPHENOL A DIMETHYL ETHER (3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE (3R)-(+)-3-(ETHYLAMINO)PYRROLIDINE [2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYL]METHYLAMINE 1H-Indol-2-amine 1-Piperazineethanamine,-alpha-,-alpha-,4-trimethyl-(9CI) HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE CHAETOMIN BENZENEMETHANAMINE, 2-AMINO-ALPHA,ALPHA-DIMETHYL CHEMBRDG-BB 4012298 2-(3-PHENYL-PYRROLIDIN-1-YL)-ETHYLAMINE CYCLO(-D-ALA-D-ALA) 2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYLAMINE (S)-2-HYDROXYMETHYL-PIPERAZINE 1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE

  • CTM
  • CS-1
  • CHETOMIN
  • CHAETOMIN
  • Chetomin,Chaetomin
  • Chetomin,Chaetomiumspecies
  • CHETOMIN(RG)
  • NSC 289491
  • Stereoisomer of 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
  • Monoclonal Anti-HSF4 antibody produced in mouse
  • DKFZp313O1039
  • SSFA2
  • ANTI-HSF4 antibody produced in mouse
  • HSF4
  • (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
  • Chetomin (NSC 289491)
  • 3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-, (3S,5aR,10bS,11aS)-
  • NSC289491， BRN0077366
  • Rabbit Anti-HSF4 antibody
  • Chetomin, HIF signaling inhibitor
  • 1403-36-7
  • C31H30N6O6S4